{"title":"多环芳烃生物标志物对心血管疾病的影响。","authors":"Nie Qigang, Arghavan Afra, Andrés Alexis Ramírez-Coronel, Abduladheem Turki Jalil, Mohammad Javad Mohammadi, M Abdulfadhil Gatea, Efriza, Parisa Asban, Seyede Kosar Mousavi, Parnia Kanani, Fatemeh Mombeni Kazemi, Maryam Hormati, Fatemeh Kiani","doi":"10.1515/reveh-2023-0070","DOIUrl":null,"url":null,"abstract":"<p><p>Polycyclic aromatic hydrocarbon (PAHs) are part of particulate matter (PM), which is produced from incomplete combustion of organic matter. Biomarkers mean biological indicators, molecules that indicate a normal or abnormal process in the body and may be a sign of a condition or disease. Studies show that PAHs increase the risk of cardiovascular diseases through processes such as oxidative stress, inflammation and atherosclerosis. The present study focused on the evaluation of health effects PAHs biomarkers on cardiovascular diseases (CVD). In this narrative study, data were collected from databases such as Scopus, PubMed, Web of science and Google Scholar in the period 1975-2023. After screening, duplicate and irrelevant articles were removed. Finally, 68 articles related to the effect of PAHs on CVD were included in the study. In addition to the articles found through the search in databases, another 18 articles from the references of the selected articles were included. According to the finding in during the biotransformation of PAH, a number of metabolites are made, such as phenols, diols, quinones, and epoxides. Phenolic isomers have the highest percentage and biomarkers used for their detection include 2-OHNAP used to trace naphthalene from heating processed food, 3-OHPHEN used to trace phenanthrene from diesel, 2-OHFLU used to trace fluorene and 1-OHPYR used to trace pyrene from cigarette and hookah smoke. According to the result, increasing blood pressure and heart rate and causing atherosclerosis are the main complications due to exposure to PAH metabolite on cardiovascular system. The most important agents that causes this affects including increased homocysteine, cholesterol, high-density lipoprotein (HDL), low-density lipoprotein (LDL), serum biomarkers of C-reactive protein, and triglycerides. Result this study showed that cardiovascular diseases risk is increased by exposure to PAH biomarkers from smoking, car emissions, occupational exposure, and incinerators. Therefore, strict controls should be implemented for sources of PAH production and exposure.</p>","PeriodicalId":21165,"journal":{"name":"Reviews on Environmental Health","volume":null,"pages":null},"PeriodicalIF":3.0000,"publicationDate":"2023-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"The effect of polycyclic aromatic hydrocarbon biomarkers on cardiovascular diseases.\",\"authors\":\"Nie Qigang, Arghavan Afra, Andrés Alexis Ramírez-Coronel, Abduladheem Turki Jalil, Mohammad Javad Mohammadi, M Abdulfadhil Gatea, Efriza, Parisa Asban, Seyede Kosar Mousavi, Parnia Kanani, Fatemeh Mombeni Kazemi, Maryam Hormati, Fatemeh Kiani\",\"doi\":\"10.1515/reveh-2023-0070\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Polycyclic aromatic hydrocarbon (PAHs) are part of particulate matter (PM), which is produced from incomplete combustion of organic matter. 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Phenolic isomers have the highest percentage and biomarkers used for their detection include 2-OHNAP used to trace naphthalene from heating processed food, 3-OHPHEN used to trace phenanthrene from diesel, 2-OHFLU used to trace fluorene and 1-OHPYR used to trace pyrene from cigarette and hookah smoke. According to the result, increasing blood pressure and heart rate and causing atherosclerosis are the main complications due to exposure to PAH metabolite on cardiovascular system. The most important agents that causes this affects including increased homocysteine, cholesterol, high-density lipoprotein (HDL), low-density lipoprotein (LDL), serum biomarkers of C-reactive protein, and triglycerides. Result this study showed that cardiovascular diseases risk is increased by exposure to PAH biomarkers from smoking, car emissions, occupational exposure, and incinerators. 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引用次数: 0
摘要
多环芳烃(PAHs)是颗粒物(PM)的一部分,颗粒物是由有机物的不完全燃烧产生的。生物标志物是指生物指标,即指示身体正常或异常过程的分子,可能是疾病或疾病的迹象。研究表明,多环芳烃通过氧化应激、炎症和动脉粥样硬化等过程增加了患心血管疾病的风险。本研究的重点是评估多环芳烃生物标志物对心血管疾病(CVD)的健康影响。在这项叙述性研究中,数据是从Scopus、PubMed、Web of science和Google Scholar等数据库中收集的,时间为1975-2023年。筛选后,删除重复和不相关的文章。最后,本研究纳入了68篇关于多环芳烃对心血管疾病影响的文章。除了在数据库中搜索到的文章外,还包括所选文章参考文献中的另外18篇文章。根据中的发现,在PAH的生物转化过程中,会产生许多代谢产物,如苯酚、二醇、醌和环氧化物。酚类异构体的百分比最高,用于检测的生物标志物包括用于追踪加热加工食品中萘的2-OHNAP、用于追踪柴油中菲的3-OHPHEN、用于追踪芴的2-OHFLU和用于追踪香烟和水烟烟雾中芘的1-OHPYR。研究结果表明,暴露于PAH代谢产物对心血管系统的影响是导致血压和心率升高并导致动脉粥样硬化的主要并发症。引起这种影响的最重要因素包括同型半胱氨酸、胆固醇、高密度脂蛋白(HDL)、低密度脂蛋白、血清C反应蛋白生物标志物和甘油三酯的增加。研究结果表明,暴露于吸烟、汽车排放、职业暴露和焚烧炉等多环芳烃生物标志物会增加心血管疾病的风险。因此,应严格控制多环芳烃的产生和暴露来源。
The effect of polycyclic aromatic hydrocarbon biomarkers on cardiovascular diseases.
Polycyclic aromatic hydrocarbon (PAHs) are part of particulate matter (PM), which is produced from incomplete combustion of organic matter. Biomarkers mean biological indicators, molecules that indicate a normal or abnormal process in the body and may be a sign of a condition or disease. Studies show that PAHs increase the risk of cardiovascular diseases through processes such as oxidative stress, inflammation and atherosclerosis. The present study focused on the evaluation of health effects PAHs biomarkers on cardiovascular diseases (CVD). In this narrative study, data were collected from databases such as Scopus, PubMed, Web of science and Google Scholar in the period 1975-2023. After screening, duplicate and irrelevant articles were removed. Finally, 68 articles related to the effect of PAHs on CVD were included in the study. In addition to the articles found through the search in databases, another 18 articles from the references of the selected articles were included. According to the finding in during the biotransformation of PAH, a number of metabolites are made, such as phenols, diols, quinones, and epoxides. Phenolic isomers have the highest percentage and biomarkers used for their detection include 2-OHNAP used to trace naphthalene from heating processed food, 3-OHPHEN used to trace phenanthrene from diesel, 2-OHFLU used to trace fluorene and 1-OHPYR used to trace pyrene from cigarette and hookah smoke. According to the result, increasing blood pressure and heart rate and causing atherosclerosis are the main complications due to exposure to PAH metabolite on cardiovascular system. The most important agents that causes this affects including increased homocysteine, cholesterol, high-density lipoprotein (HDL), low-density lipoprotein (LDL), serum biomarkers of C-reactive protein, and triglycerides. Result this study showed that cardiovascular diseases risk is increased by exposure to PAH biomarkers from smoking, car emissions, occupational exposure, and incinerators. Therefore, strict controls should be implemented for sources of PAH production and exposure.
期刊介绍:
Reviews on Environmental Health (REVEH) is an international peer-reviewed journal that aims to fill the need for publication of review articles on hot topics in the field of environmental health. Reviews on Environmental Health aims to be an inspiring forum for scientists, environmentalists, physicians, engineers, and students who are concerned with aspects of human health, including quality of life, that are determined by physiological and psychosociological interactions between man and physical, chemical, biological, and social factors in the environment.
Reviews on Environmental Health is an important niche served by no other journal, that’s being a site where thoughtful reviews can be published on a variety of subjects related to both health and environment. One challenge is to bridge the research on environmental causes of disease with the clinical practice of medicine. Reviews on Environmental Health is a source of integrated information on environment and health subjects that will be of value to the broad scientific community, whether students, junior and senior professionals, or clinicians.