表观遗传学机制和营养对男性和女性不育有效吗?

IF 2.4 Q3 NUTRITION & DIETETICS Journal of Nutritional Science Pub Date : 2023-09-26 eCollection Date: 2023-01-01 DOI:10.1017/jns.2023.62
Kadriye Erdoğan, Nazlı Tunca Sanlier, Nevin Sanlier
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摘要

这篇综述讨论了表观遗传学机制以及男性和女性不孕与营养相关参数的关系。全世界不孕不育的患病率为8-12%,每八对夫妇中就有一对接受治疗。表观遗传学机制、衰老、环境因素、膳食能量和营养素以及非营养化合物;或多或少的能量摄入和蛋氨酸在不孕不育的发生中发挥作用。它还与维生素B12、D和B6、生物素、胆碱、硒、锌、叶酸、白藜芦醇、槲皮素和类似因子相互作用。为了了解影响不孕不育基因表达的分子机制,必须首先考虑环境、基因型的作用、年龄、健康、营养以及个体表观基因型的变化。这将为确定不育的未知原因铺平道路。能量和某些宏观和微量营养素摄入不足或过量也可能导致不孕。此外,据报道,5-10%的体重减轻、适度的体育活动和改善胰岛素敏感性的营养干预有助于生育能力的发展。与表观遗传学有关的过程携带遗传而非通过DNA序列编码的改变。营养被认为对表观遗传学机制有影响,这些机制在不孕等几种疾病的发病机制中有效。不孕个体的表观遗传学机制与健康个体不同。不孕与表观遗传机制、营养物质、生物活性成分和许多其他因素有关。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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Are epigenetic mechanisms and nutrition effective in male and female infertility?

This review discusses epigenetic mechanisms and the relationship of infertility in men and women in relation to parameters pertaining to nutrition. The prevalence of infertility worldwide is 8-12 %, and one out of every eight couples receives medical treatment. Epigenetic mechanisms, aging, environmental factors, dietary energy and nutrients and non-nutrient compounds; more or less energy intake, and methionine come into play in the occurrence of infertility. It also interacts with vitamins B12, D and B6, biotin, choline, selenium, zinc, folic acid, resveratrol, quercetin and similar factors. To understand the molecular mechanisms regulating the expression of genes that affect infertility, the environment, the role of genotype, age, health, nutrition and changes in the individual's epigenotype must first be considered. This will pave the way for the identification of the unknown causes of infertility. Insufficient or excessive intake of energy and certain macro and micronutrients may contribute to the occurrence of infertility as well. In addition, it is reported that 5-10 % of body weight loss, moderate physical activity and nutritional interventions for improvement in insulin sensitivity contribute to the development of fertility. Processes that pertain to epigenetics carry alterations which are inherited yet not encoded via the DNA sequence. Nutrition is believed to have an impact over the epigenetic mechanisms which are effective in the pathogenesis of several diseases like infertility. Epigenetic mechanisms of individuals with infertility are different from healthy individuals. Infertility is associated with epigenetic mechanisms, nutrients, bioactive components and numerous other factors.

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来源期刊
Journal of Nutritional Science
Journal of Nutritional Science NUTRITION & DIETETICS-
CiteScore
3.00
自引率
0.00%
发文量
91
审稿时长
7 weeks
期刊介绍: Journal of Nutritional Science is an international, peer-reviewed, online only, open access journal that welcomes high-quality research articles in all aspects of nutrition. The underlying aim of all work should be, as far as possible, to develop nutritional concepts. JNS encompasses the full spectrum of nutritional science including public health nutrition, epidemiology, dietary surveys, nutritional requirements, metabolic studies, body composition, energetics, appetite, obesity, ageing, endocrinology, immunology, neuroscience, microbiology, genetics, molecular and cellular biology and nutrigenomics. JNS welcomes Primary Research Papers, Brief Reports, Review Articles, Systematic Reviews, Workshop Reports, Letters to the Editor and Obituaries.
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