Jian Zhang, Jia-Yi Su, Yang-Zi Liu, Hao Li, Quannan Wang, Wei-Ping Deng
{"title":"酮umpolung通过Pudovik加成/[1，2]-磷-布鲁克重排实现钯催化的烯丙基烷基化","authors":"Jian Zhang, Jia-Yi Su, Yang-Zi Liu, Hao Li, Quannan Wang, Wei-Ping Deng","doi":"10.1007/s11426-023-1744-2","DOIUrl":null,"url":null,"abstract":"<div><p>Palladium-catalyzed allylic alkylation enabled by ketone umpolung <i>via</i> Pudovik addition/[1,2]-phospha-Brook rearrangement with phosphites has been developed. The protocol offers a straightforward method for the synthesis of potentially bioactive homoallylic alcohol phosphonates in an efficient and economical way. This cascade reaction proceeds under mild conditions with excellent functional group compatibility. Furthermore, the catalytic asymmetric version has also been explored.</p><figure><div><div><div><picture><source><img></source></picture></div></div></div></figure></div>","PeriodicalId":772,"journal":{"name":"Science China Chemistry","volume":"66 10","pages":"2810 - 2816"},"PeriodicalIF":10.4000,"publicationDate":"2023-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s11426-023-1744-2.pdf","citationCount":"0","resultStr":"{\"title\":\"Palladium-catalyzed allylic alkylation enabled by ketone umpolung via Pudovik addition/[1,2]-phospha-Brook rearrangement\",\"authors\":\"Jian Zhang, Jia-Yi Su, Yang-Zi Liu, Hao Li, Quannan Wang, Wei-Ping Deng\",\"doi\":\"10.1007/s11426-023-1744-2\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>Palladium-catalyzed allylic alkylation enabled by ketone umpolung <i>via</i> Pudovik addition/[1,2]-phospha-Brook rearrangement with phosphites has been developed. The protocol offers a straightforward method for the synthesis of potentially bioactive homoallylic alcohol phosphonates in an efficient and economical way. This cascade reaction proceeds under mild conditions with excellent functional group compatibility. Furthermore, the catalytic asymmetric version has also been explored.</p><figure><div><div><div><picture><source><img></source></picture></div></div></div></figure></div>\",\"PeriodicalId\":772,\"journal\":{\"name\":\"Science China Chemistry\",\"volume\":\"66 10\",\"pages\":\"2810 - 2816\"},\"PeriodicalIF\":10.4000,\"publicationDate\":\"2023-09-11\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://link.springer.com/content/pdf/10.1007/s11426-023-1744-2.pdf\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Science China Chemistry\",\"FirstCategoryId\":\"1\",\"ListUrlMain\":\"https://link.springer.com/article/10.1007/s11426-023-1744-2\",\"RegionNum\":1,\"RegionCategory\":\"化学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"CHEMISTRY, MULTIDISCIPLINARY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Science China Chemistry","FirstCategoryId":"1","ListUrlMain":"https://link.springer.com/article/10.1007/s11426-023-1744-2","RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CHEMISTRY, MULTIDISCIPLINARY","Score":null,"Total":0}
Palladium-catalyzed allylic alkylation enabled by ketone umpolung via Pudovik addition/[1,2]-phospha-Brook rearrangement
Palladium-catalyzed allylic alkylation enabled by ketone umpolung via Pudovik addition/[1,2]-phospha-Brook rearrangement with phosphites has been developed. The protocol offers a straightforward method for the synthesis of potentially bioactive homoallylic alcohol phosphonates in an efficient and economical way. This cascade reaction proceeds under mild conditions with excellent functional group compatibility. Furthermore, the catalytic asymmetric version has also been explored.
期刊介绍：
Science China Chemistry, co-sponsored by the Chinese Academy of Sciences and the National Natural Science Foundation of China and published by Science China Press, publishes high-quality original research in both basic and applied chemistry. Indexed by Science Citation Index, it is a premier academic journal in the field.
Categories of articles include:
Highlights. Brief summaries and scholarly comments on recent research achievements in any field of chemistry.
Perspectives. Concise reports on thelatest chemistry trends of interest to scientists worldwide, including discussions of research breakthroughs and interpretations of important science and funding policies.
Reviews. In-depth summaries of representative results and achievements of the past 5–10 years in selected topics based on or closely related to the research expertise of the authors, providing a thorough assessment of the significance, current status, and future research directions of the field.
京公网安备 11010802042870号
京ICP备2023020795号-1
分享
求助内容：
应助结果提醒方式：
扫码关注我们
