急性髓系白血病外泌体来源microRNA的研究现状

国际输血及血液学杂志 Pub Date : 2020-01-20 DOI:10.3760/CMA.J.ISSN.1673-419X.2020.01.005

Zhewei He

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引用次数: 0

摘要

急性粒细胞白血病（AML）复发率高、病死率高、耐药率高，是亟待解决的主要问题和研究热点。大量研究证实，外泌体衍生的微小RNA（miRNA）在疾病过程中发挥着重要作用，如调节骨髓微环境、AML中肿瘤血管的形成以及参与耐药性的发生。因此，外泌体衍生的miRNA在AML中的相关研究为改善AML患者的预后和克服耐药性提供了新的研究方向。本文旨在介绍外泌体衍生的miRNA在AML中的相关作用及其介导的AML耐药性机制。关键词：白血病，髓系，急性；外泌体；微小RNA；耐药性，肿瘤；肿瘤微环境

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Research status of exosome-derived microRNA in acute myeloid leukemia

Acute myeloid leukemia (AML) has a high recurrence rate, high case fatality rate and drug resistance, which are major problems to be solved and a research hotspot. A number of researches confirmed that exosome-derived microRNA (miRNA) plays an important role in the disease process, such as the regulation of bone marrow microenvironment, formation of tumor blood vessels in AML, and participating in the occurrence of drug resistance. So for exosome-derived miRNA related researches in AML provide the new research direction to improve the prognosis of patients with AML and overcome drug resistance. The article intends to introduce the related role of exosome-derived miRNA in AML and the drug resistance mechanism of AML mediated by them. Key words: Leukemia, myeloid, acute; Exosomes; MicroRNAs; Drug resistance, neoplasm; Tumor microenvironment

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来源期刊

国际输血及血液学杂志

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0.00%

发文量

10610

期刊介绍： The International Journal of Transfusion and Hematology was founded in September 1978. It is a comprehensive academic journal in the field of transfusion and hematology, supervised by the National Health Commission and co-sponsored by the Chinese Medical Association, West China Second Hospital of Sichuan University, and the Institute of Transfusion Medicine of the Chinese Academy of Medical Sciences. The journal is a comprehensive academic journal that combines the basic and clinical aspects of transfusion and hematology and is publicly distributed at home and abroad. The International Journal of Transfusion and Hematology mainly reports on the basic and clinical scientific research results and progress in the field of transfusion and hematology, new experiences, new methods, and new technologies in clinical diagnosis and treatment, introduces domestic and foreign research trends, conducts academic exchanges, and promotes the development of basic and clinical research in the field of transfusion and hematology.