J. Cheraghi, Parisa Kridhchi, S. Nasri, M. Zargooshi
{"title":"香芹水醇提取物对链脲佐菌素诱导的糖尿病雄性大鼠Cheraghi Javad、Kerishchi Khyabani Parisa、Nasri Sima、Zargushi Maryam精子发生和垂体-性腺轴的影响","authors":"J. Cheraghi, Parisa Kridhchi, S. Nasri, M. Zargooshi","doi":"10.22059/IJVM.2021.312948.1005139","DOIUrl":null,"url":null,"abstract":"AbstractEffects of Parsley (Petroselinum Crispum) Hydroalcoholic Extract on Spermatogenesis and Pituitary- Gonadal Axis in Streptozotocin- Induced Diabetic Male RatBackground: Diabetes mellitus (DM), as a metabolic disease, has a high rate of mortality all over the world. In recent years, there is accumulating evidence that showing this complex multifactorial disease has various effects on reproductive system. Objective: This study aimed to investigate the effect of hydroalcoholic extract of parsley(Petroselinum crispum) leaves on spermatogenesis and pituitary gonadal axis in male streptozotocin (STZ) - induced diabetic ratMethods: In the present study, 60 male rats were divided into 5 groups of 12 animals in each: control, DM control and 3 experimental groups (treated with doses 1g/kg, 2g/kg and 4 g/kg of hydroalcoholic extract of parsley leaves gavage for 28 days). DM was induced intraperitoneal injection of a single dose of STZ (65mg/kg). At the end of the treatment, mice were bled from the heart and follicle-stimulating hormone (FSH), Luteinizing hormone (LH) and testosterones were measured. The testes of mice were isolated and weighted. Results: Comparison of LH, FSH and testosterone in rats treated with doses 1mg/kg of hydro-alcoholic extraction of plant revealed a significant increase as compared the diabetic control group (p <0/05). In addition, the results of histological elucidated that the experimental group (1mg/kg) a significant increase in sperm cells, motility, testis weight, total sperm count relative to diabetic control (P <0.001). Conclusion: It seems that parsley (Petroselinum Crispum) hydroalcoholic extract can be effective in decreasing the reproductive disorders in of DM patient. Key words: Diabetes mellitus, Parsley Medicinal Plants, Rat, Reproductive system, Sex Hormone, spermatogenesis","PeriodicalId":14566,"journal":{"name":"Iranian Journal of Veterinary Medicine","volume":"21 4","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2021-08-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"2","resultStr":"{\"title\":\"Effects of parsley (Petroselinum Crispum) hydroalcoholic extract on spermatogenesis and Pituitary- Gonadal axis in streptozotocin- induced diabetic male rat Cheraghi Javad, Kerishchi Khyabani Parisa, Nasri Sima, Zargushi Maryam\",\"authors\":\"J. Cheraghi, Parisa Kridhchi, S. Nasri, M. Zargooshi\",\"doi\":\"10.22059/IJVM.2021.312948.1005139\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"AbstractEffects of Parsley (Petroselinum Crispum) Hydroalcoholic Extract on Spermatogenesis and Pituitary- Gonadal Axis in Streptozotocin- Induced Diabetic Male RatBackground: Diabetes mellitus (DM), as a metabolic disease, has a high rate of mortality all over the world. In recent years, there is accumulating evidence that showing this complex multifactorial disease has various effects on reproductive system. Objective: This study aimed to investigate the effect of hydroalcoholic extract of parsley(Petroselinum crispum) leaves on spermatogenesis and pituitary gonadal axis in male streptozotocin (STZ) - induced diabetic ratMethods: In the present study, 60 male rats were divided into 5 groups of 12 animals in each: control, DM control and 3 experimental groups (treated with doses 1g/kg, 2g/kg and 4 g/kg of hydroalcoholic extract of parsley leaves gavage for 28 days). DM was induced intraperitoneal injection of a single dose of STZ (65mg/kg). At the end of the treatment, mice were bled from the heart and follicle-stimulating hormone (FSH), Luteinizing hormone (LH) and testosterones were measured. The testes of mice were isolated and weighted. Results: Comparison of LH, FSH and testosterone in rats treated with doses 1mg/kg of hydro-alcoholic extraction of plant revealed a significant increase as compared the diabetic control group (p <0/05). In addition, the results of histological elucidated that the experimental group (1mg/kg) a significant increase in sperm cells, motility, testis weight, total sperm count relative to diabetic control (P <0.001). Conclusion: It seems that parsley (Petroselinum Crispum) hydroalcoholic extract can be effective in decreasing the reproductive disorders in of DM patient. 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Effects of parsley (Petroselinum Crispum) hydroalcoholic extract on spermatogenesis and Pituitary- Gonadal axis in streptozotocin- induced diabetic male rat Cheraghi Javad, Kerishchi Khyabani Parisa, Nasri Sima, Zargushi Maryam
AbstractEffects of Parsley (Petroselinum Crispum) Hydroalcoholic Extract on Spermatogenesis and Pituitary- Gonadal Axis in Streptozotocin- Induced Diabetic Male RatBackground: Diabetes mellitus (DM), as a metabolic disease, has a high rate of mortality all over the world. In recent years, there is accumulating evidence that showing this complex multifactorial disease has various effects on reproductive system. Objective: This study aimed to investigate the effect of hydroalcoholic extract of parsley(Petroselinum crispum) leaves on spermatogenesis and pituitary gonadal axis in male streptozotocin (STZ) - induced diabetic ratMethods: In the present study, 60 male rats were divided into 5 groups of 12 animals in each: control, DM control and 3 experimental groups (treated with doses 1g/kg, 2g/kg and 4 g/kg of hydroalcoholic extract of parsley leaves gavage for 28 days). DM was induced intraperitoneal injection of a single dose of STZ (65mg/kg). At the end of the treatment, mice were bled from the heart and follicle-stimulating hormone (FSH), Luteinizing hormone (LH) and testosterones were measured. The testes of mice were isolated and weighted. Results: Comparison of LH, FSH and testosterone in rats treated with doses 1mg/kg of hydro-alcoholic extraction of plant revealed a significant increase as compared the diabetic control group (p <0/05). In addition, the results of histological elucidated that the experimental group (1mg/kg) a significant increase in sperm cells, motility, testis weight, total sperm count relative to diabetic control (P <0.001). Conclusion: It seems that parsley (Petroselinum Crispum) hydroalcoholic extract can be effective in decreasing the reproductive disorders in of DM patient. Key words: Diabetes mellitus, Parsley Medicinal Plants, Rat, Reproductive system, Sex Hormone, spermatogenesis
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