未来治疗牙周病的子弹:化学修饰四环素

Q3 Biochemistry, Genetics and Molecular Biology Journal of Cellular Biotechnology Pub Date : 2021-10-30 DOI:10.3233/jcb-210040
Shivani Sachdeva, A. Mani, H. Saluja
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引用次数: 1

摘要

慢性牙周炎现在普遍被认为是生态失调,b[1],它会破坏富含胶原蛋白的组织,如牙周韧带、牙槽骨和牙龈结缔组织。口腔生物膜包含许多被认为是引起慢性牙周炎的“诱因”的牙周病原体。因为,并不是每个人都会以同样的方式受到牙周病原体的影响。有些可能不会引起宿主的反应,而另一些可能会有夸张的反应。因此,宿主调节疗法应运而生,以抵消宿主的过度反应。化学修饰四环素(CMTs)已被用于抑制炎症反应或降低宿主的胶原溶解活性。虽然是四环素的衍生物,但它仍然缺乏抗菌作用,因此,可以用于牙周炎较长时间,没有母体四环素具有的胃肠道毒性的不良影响。
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Bullet for periodontal disease in future: Chemically modified tetracyclines
Chronic periodontitis is nowadays popularly regarded as Dysbiosis, [1] which causes destruction of tissues rich in collagen like periodontal ligament, alveolar bone and gingival connective tissue. The oral biofilm comprises many periodontal pathogens better regarded as ‘triggers’ in causing chronic periodontitis. Since, not everyone will be affected in the same manner due to periodontal pathogens. Some might not elicit a host response while, the others might have exaggerated response. So, host modulation therapy came into existence to counteract the exaggerated host response. The chemically modified tetracyclines (CMTs) have emerged to inhibit the inflammatory response or to reduce the collagenolytic activity of host. Though a derivative of tetracyclines, it still lacks an antimicrobial action and hence, can be used for periodontitis for longer duration with no adverse effects of gastrointestinal toxicity which parent tetracyclines have.
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来源期刊
Journal of Cellular Biotechnology
Journal of Cellular Biotechnology Biochemistry, Genetics and Molecular Biology-Biotechnology
CiteScore
0.70
自引率
0.00%
发文量
13
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