Clinical characteristics of COVID-19 among hospital staff

Objective: To investigate the clinical characteristics of hospital staff with COVID-19, so as to reduce hospital transmission, improve the cure rate and reduce the mortality Methods: A total of 95 staff with COVID-19 in the isolation ward of Renmin Hospital of Wuhan University were selected as the study subjects from January 31 to February 10, 2020 Their clinical symptoms, results of blood test, respiratory virus nasopharyngeal swab RNA detection, novel coronavirus RNA detection (sputum, stool), chest CT imaging, and clinical outcomes were reviewed Results: (1) Among the staff with COVID-19 infection, the median age was 35 years old The cases of female were more than male cases (61 cases versus 34 cases), and most cases (81 cases) were doctors, nurses, or medical technicians Twelve (12 6%) patients had chronic diseases Invasive operations (endotracheal intubation, gastroscopy, nasopharyngoscopy, hemodialysis, etc ) were performed in 9 cases(9 5%) According to the clinical classification, 5 cases were mild (5 3%), 84 cases were in common type (88 4%), 5 cases were severe (5 3%), and one case was in very severe type (1 1%) The median time from onset of symptoms to first hospital admission was 5 days (2) The most common symptoms at onset were fever in 67 cases (70 5%), cough in 60 cases (63 2%), fatigue in 39 cases (41 1%), and so on (3) The total leukocyte count was normal or decreased in 90 cases (94 7%), the neutrophil count was normal in 75 cases (78 9%), and lymphocyte count decreased in 29 cases (30 5%) Hypersensitive C-reactive protein increased in 21 cases (22 1%) There was no significant change in platelet count and renal function (creatinine) 43 (45 3%) patients had decreased total protein, 36 (37 9%) patients had decreased albumin, and 12 (12 6%) patients had elevated transaminase Among them, 78 patients were tested for RNA from nasopharyngeal swabs of other common respiratory viruses, and only 3 patients were positive (4) According to CT imaging, there were pneumonia-like changes in the lungs of 90 patients, and 66 patients (69 5%) showed bilateral pneumonia Among them, 70 cases (73 7%) showed flaky, patchy, patchy ground glass shadow or flocculent shadow, as well as some with cord shadow Among them, 3 cases (3 2%) showed consolidation as the main manifestation, and bronchial inflation sign was seen in some cases One patient (1 1%) was complicated with pleural effusion and pericardial effusion Conclusion: The clinical symptoms, blood test and chest CT imaging findings of COVID-19 of hospital staff are similar to those of ordinary patients, but the age and sex distribution and prognosis of hospital staff are different from those of ordinary patients Infection among hospital staff may be transmitted through close contact with patients, aerosol transmission, droplet transmission, various high-risk medical operations, family gathering, etc © 2021, Editorial Board of Medical Journal of Wuhan University All right reserved