Intrauterine honey infusion in Holstein Frisian cows with purulent endometritis

Endometritis is one of the major gynecological problems affecting reproductive performance and economy of milk production in dairy cows. Since multidrug resistant bacteria (MDR) is widely global spread, alternative therapeutic agents is urgently needed. By the gynecological investigation of 566 Holstein Frisian lactating cows, 38 suffering from repeat breeder (RB) were showing purulent exudative endometritis (PE). Different Staphylococcus and Streptococcus spp . were isolated, identificated and subjected to antimicrobial assessment, where all tested strains were MDR with overall multi antimicrobial resistance index (MAR) 0.42, while when be tested against Egyptian cotton honey achieved only 10 & 20% minimum inhibitory concentration (MIC). Twenty four cows of the affected cows were included in the study were divided to three groups; (A): 6 cows did not receive any previous treatment, while (B): 10 cows did not respond to long different classic treatment and (C): 8 cows did not receive any management and left as a control group. Both groups A & B received I/U of 100 ml of full strength Egyptian cotton honey infusion day /day for three successive infusions until purulent exudate clearance or up to three successive infusions. Success results were judged by conception rate (CR), where it was 80% for group A and 70% for group B with overall conception rate for all honey treated cows of 75%. It was concluded that I/U honey is a very effective successful management for bovine PE especially those antibiotic none-responding since it would clear the pyogenic infection with high conception rate.