M. Shokrzadeh, F. Motafeghi, N. Farhadyar, F. Fathi
{"title":"共沉淀法合成nHAP/壳聚糖和nHAP/纤维素复合支架骨组织工程细胞毒性研究","authors":"M. Shokrzadeh, F. Motafeghi, N. Farhadyar, F. Fathi","doi":"10.4028/p-14k07c","DOIUrl":null,"url":null,"abstract":"The main purpose of this study is to synthesize nano-hydroxyapatite/cellulose (nHAP/Cel) and nano-hydroxyapatite/chitosan (nHAP/CS) scaffolds via co-precipitation method for bone tissue engineering due to their suitable biocompatibility, cytotoxicity and mechanical properties. The characterizations of these scaffolds were investigated by Infrared absorption spectra (FT-IR), X-ray Diffraction (XRD), and Scanning Electron Microscope (SEM). The cytotoxicity of these nanoparticles was evaluated with bone marrow cell using the 3-(4, 5-Dimethylthiazol-2-yl)-2, 5-diphenyl-tetrazoliumbromide) (MTT) assay. The porosity of scaffolds was estimated 87%. The results indicate that the nano composite scaffolds have good morphology, tissue biocompatibility and biodegradability to be used for tissue engineering.","PeriodicalId":15161,"journal":{"name":"Journal of Biomimetics, Biomaterials and Biomedical Engineering","volume":"60 1","pages":"1 - 10"},"PeriodicalIF":0.5000,"publicationDate":"2023-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"1","resultStr":"{\"title\":\"Cytotoxicity Study of nHAP/Chitosan and nHAP/Cellulose Composite Scaffolds Synthesized via Co-Precipitation for Bone Tissue Engineering\",\"authors\":\"M. Shokrzadeh, F. Motafeghi, N. Farhadyar, F. Fathi\",\"doi\":\"10.4028/p-14k07c\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"The main purpose of this study is to synthesize nano-hydroxyapatite/cellulose (nHAP/Cel) and nano-hydroxyapatite/chitosan (nHAP/CS) scaffolds via co-precipitation method for bone tissue engineering due to their suitable biocompatibility, cytotoxicity and mechanical properties. The characterizations of these scaffolds were investigated by Infrared absorption spectra (FT-IR), X-ray Diffraction (XRD), and Scanning Electron Microscope (SEM). The cytotoxicity of these nanoparticles was evaluated with bone marrow cell using the 3-(4, 5-Dimethylthiazol-2-yl)-2, 5-diphenyl-tetrazoliumbromide) (MTT) assay. The porosity of scaffolds was estimated 87%. The results indicate that the nano composite scaffolds have good morphology, tissue biocompatibility and biodegradability to be used for tissue engineering.\",\"PeriodicalId\":15161,\"journal\":{\"name\":\"Journal of Biomimetics, Biomaterials and Biomedical Engineering\",\"volume\":\"60 1\",\"pages\":\"1 - 10\"},\"PeriodicalIF\":0.5000,\"publicationDate\":\"2023-05-31\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"1\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Biomimetics, Biomaterials and Biomedical Engineering\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.4028/p-14k07c\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"ENGINEERING, BIOMEDICAL\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Biomimetics, Biomaterials and Biomedical Engineering","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.4028/p-14k07c","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"ENGINEERING, BIOMEDICAL","Score":null,"Total":0}
Cytotoxicity Study of nHAP/Chitosan and nHAP/Cellulose Composite Scaffolds Synthesized via Co-Precipitation for Bone Tissue Engineering
The main purpose of this study is to synthesize nano-hydroxyapatite/cellulose (nHAP/Cel) and nano-hydroxyapatite/chitosan (nHAP/CS) scaffolds via co-precipitation method for bone tissue engineering due to their suitable biocompatibility, cytotoxicity and mechanical properties. The characterizations of these scaffolds were investigated by Infrared absorption spectra (FT-IR), X-ray Diffraction (XRD), and Scanning Electron Microscope (SEM). The cytotoxicity of these nanoparticles was evaluated with bone marrow cell using the 3-(4, 5-Dimethylthiazol-2-yl)-2, 5-diphenyl-tetrazoliumbromide) (MTT) assay. The porosity of scaffolds was estimated 87%. The results indicate that the nano composite scaffolds have good morphology, tissue biocompatibility and biodegradability to be used for tissue engineering.
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