Investigation of FOXP3 (rs3761548) polymorphism with the risk of preeclampsia and recurrent spontaneous abortion: A systemic review and meta-analysis

Objective: To investigate the association between forkhead box P3 (FOXP3) (rs3761548) polymorphism and the risk of preeclampsia and recurrent spontaneous abortion. Methods: Literature on the association of FOXP3 gene polymorphisms and susceptibility to preeclampsia and unexplained recurrent spontaneous abortion was retrieved by searching databases such as PubMed, Science Direct, Google Scholar and Embase from 2000 to 2021. The association measure was analyzed using an odds ratio (OR) and 95% confidence interval (CI). All the statistical analyses were executed using RevMan 5.4 software. Results: In the present meta-analysis, 11 articles were analyzed. The pooled results showed no association between FOXP3 gene polymorphism (rs3761548) and preeclampsia risk in allelic, recessive, dominant and over dominant contrast models. FOXP3 gene polymorphism (rs3761548) showed an association with recurrent abortion in allelic, recessive and dominant models (OR 1.85, CI 1.59-2.14; OR 2.02, 95% CI 1.56-2.62; OR 2.69, 95% CI 1.50-4.83, respectively), while no association in the over dominant contrast model (OR 1.35, CI 0.87-2.10). Conclusions: In the present study, FOXP3 gene (rs3761548) polymorphism is associated with risk of recurrent spontaneous abortion but not preeclampsia. However, larger sample size and multiracial studies are needed in the future to confirm the findings.