放化疗对胶质母细胞瘤患者抗肿瘤免疫的影响及治疗启示

Q4 Medicine 肿瘤研究与临床 Pub Date : 2019-12-28 DOI:10.3760/CMA.J.ISSN.1006-9801.2019.12.016

Mingxiao Li, Haihui Jiang

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引用次数: 0

摘要

胶质母细胞瘤是最恶性的原发性脑肿瘤，预后极差。近年来，免疫疗法已成为恶性肿瘤治疗的热点问题。传统的治疗方案结合免疫疗法可能在GBM的诊断和治疗方面取得进展。本文综述了传统放化疗影响机体抗肿瘤和免疫机制的解释，以及目前标准放化疗与免疫疗法相结合的成果，以探索对GBM患者的潜在益处。关键词：胶质母细胞瘤；免疫治疗；药物治疗，联合用药；放射治疗

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Effect of chemoradiotherapy on anti-tumor immunity of glioblastoma patients and treatment enlightement

Glioblastoma (GBM) is the most malignant primary brain tumor, and it has very poor prognosis. In recent years, the immunotherapy has become a hot issue in the treatment of malignancies. The traditional treatment regimen combined with immunotherapy might make a progress in the diagnosis and treatment of GBM. This paper reviews the explanation of the traditional chemoradiotherapy affecting the body's anti-tumor and immunity mechanism, and the current achievement of standard chemoradiotherapy combined with immunotherapy, to explore the potential benefits to GBM patients. Key words: Glioblastoma; Immunotherapy; Drug therapy, combination; Radiotherapy

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来源期刊

肿瘤研究与临床 Medicine-Oncology

CiteScore

0.10

自引率

0.00%

发文量

7737

期刊介绍： "Cancer Research and Clinic" is a series of magazines of the Chinese Medical Association under the supervision of the National Health Commission and sponsored by the Chinese Medical Association. It mainly reflects scientific research results and academic trends in the field of malignant tumors. The main columns include monographs, guidelines and consensus, standards and norms, treatises, short treatises, survey reports, reviews, clinical pathology (case) discussions, case reports, etc. The readers are middle- and senior-level medical staff engaged in basic research and clinical work on malignant tumors.