Research progress on function of regulatory T cell in myeloproliferative neoplasms

Myeloproliferative neoplasms (MPN) are a group of abnormal clonal diseases of hematopoietic stem cell, which characterized by sustained clonal proliferation of relatively mature differentiated one or more myeloid cells. MPN mainly include chronic myeloid leukemia (CML) and Ph-/MPN. In recent years, studies have reported that abnormal number and function of regulatory T cell (Treg) play an important role in the occurrence and development of MPN. Therefore, this article reviews recent research advances in the biological characteristics of Treg, relationship between number of Treg in CML patients and CML clinical phase, Sokal score, efficacy and transcription level of BCR-ABL fusion gene, as well as the role of Treg in the pathogenesis and progression of Ph- MPN. Key words: T-lymphocytes; T-lymphocytes, regulatory; Myeloproliferative disorders; Leukemia, myelogenous, chronic, BCR-ABL positive; Treatment outcome; Neoplasm staging