蒽环类药物相关心脏毒性的发病机制、诊断和治疗研究进展

国际输血及血液学杂志 Pub Date : 2019-07-20 DOI:10.3760/CMA.J.ISSN.1673-419X.2019.04.012

Yu Tian

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引用次数: 0

摘要

蒽环类药物是一种细胞毒性药物，对多种恶性肿瘤都有很高的疗效，被广泛用于儿童恶性肿瘤的治疗。但是与蒽环类药物相关的剂量累积性心脏毒性会影响儿童的生活质量，甚至导致心力衰竭。近年来，随着对ANT的心脏毒性的认识，对ANT治疗的患者进行心脏监测，采取早期干预措施预防或治疗心力衰竭已成为必要。本文就ANT相关心脏毒性的发病机制、诊断和治疗方面的研究进展作一综述。关键词:蒽环类药物;药物毒性;心脏毒素;心力衰竭;Dexrazoxane

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Research progress in pathogenesis, diagnosis and treatment of anthracyclines related cardiotoxicity

Anthracyclines (ANT) are cytotoxic drugs that are highly effective against a variety of malignancies and are widely used in the treatment of childhood malignancies.But the dose-cumulative cardiotoxicity associated with anthracyclines can affect the quality of life in children, and even cause heart failure. In recent years, with the recognition of the cardiotoxicity of ANT, cardiac monitoring has become necessary to patients treated with ANT and to take early interventions to prevent or treat heart failure.This article reviews the recent advances in the pathogenesis, diagnosis and treatment of ANT related cardiotoxicity. Key words: Anthracyclines; Drug toxicity; Cardiotoxins; Heart failure; Dexrazoxane

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来源期刊

国际输血及血液学杂志

自引率

0.00%

发文量

10610

期刊介绍： The International Journal of Transfusion and Hematology was founded in September 1978. It is a comprehensive academic journal in the field of transfusion and hematology, supervised by the National Health Commission and co-sponsored by the Chinese Medical Association, West China Second Hospital of Sichuan University, and the Institute of Transfusion Medicine of the Chinese Academy of Medical Sciences. The journal is a comprehensive academic journal that combines the basic and clinical aspects of transfusion and hematology and is publicly distributed at home and abroad. The International Journal of Transfusion and Hematology mainly reports on the basic and clinical scientific research results and progress in the field of transfusion and hematology, new experiences, new methods, and new technologies in clinical diagnosis and treatment, introduces domestic and foreign research trends, conducts academic exchanges, and promotes the development of basic and clinical research in the field of transfusion and hematology.