一些胡椒-4- 1衍生物的合成及其抑菌活性研究

IF 0.4 Q4 CHEMISTRY, MULTIDISCIPLINARY Jordan Journal of Chemistry Pub Date : 2022-12-01 DOI:10.47014/17.3.2
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引用次数: 0

摘要

通过(E)-3-(2-乙氧基苯基)-1-(2-甲氧基-2-基)丙-2-烯-1-酮(I)与乙醇胺的反应,合成了新的化合物2-(2-乙基苯基)-5-羟基-1-(2-羟乙基)-5-甲基哌啶-4-酮(II)。该化合物用于在酸性介质中与氨基硫脲反应合成(Z)-2-((2S,5S)-2-(2-乙氧基苯基)-5-羟基-1-(2-羟乙基)-5-甲基哌啶-4-亚基)肼-1-甲硫酰胺(III)。通过光谱数据(IR、1H-NMR和LC-MS)证实了结构。采用琼脂稀释法研究了新合成的哌啶-4-酮衍生物对革兰氏阳性菌(金黄色葡萄球菌)和革兰氏阴性菌(肠杆菌属)的潜在抗菌效果。结果表明,化合物(III)比化合物(II)具有更高的抗菌活性。
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Synthesis and Antimicrobial Activity of Some Piperid-4-one Derivatives against Bacterial Strains
A novel compound 2-(2-ethoxyphenyl)-5-hydroxy-1-(2-hydroxyethyl)-5-methyl piperidin-4-one (II) has been synthesized by a previously well-known reaction between (E)-3-(2-ethoxyphenyl)-1-(2-methyloxiran-2-yl)prop-2-en-1-one (I) and ethanol amine. The compound was used to synthesize (Z)-2-((2S,5S)-2-(2-ethoxyphenyl)-5-hydroxy-1-(2-hydroxyethyl)-5-methylpiperidin-4-ylidene)hydrazine-1-carbothioamide (III) through con-den¬sation with thiosemicarbazide in acidic medium. Structures were confirmed by spectral data (IR,1H-NMR and LC-MS). Potential antimicrobial efficiency of the newly synthesized piperidin-4-one derivatives was studied against a Gram-positive bacterial strain (Staphylococcus aureus) and a Gram-negative bacterial strain (Enterobacter sp.) applying the agar dilution method. The results showed that compound (III) has a higher antimicrobial activity than compound (II).
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来源期刊
Jordan Journal of Chemistry
Jordan Journal of Chemistry CHEMISTRY, MULTIDISCIPLINARY-
CiteScore
0.50
自引率
0.00%
发文量
7
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