{"title":"一些胡椒-4- 1衍生物的合成及其抑菌活性研究","authors":"","doi":"10.47014/17.3.2","DOIUrl":null,"url":null,"abstract":"A novel compound 2-(2-ethoxyphenyl)-5-hydroxy-1-(2-hydroxyethyl)-5-methyl piperidin-4-one (II) has been synthesized by a previously well-known reaction between (E)-3-(2-ethoxyphenyl)-1-(2-methyloxiran-2-yl)prop-2-en-1-one (I) and ethanol amine. The compound was used to synthesize (Z)-2-((2S,5S)-2-(2-ethoxyphenyl)-5-hydroxy-1-(2-hydroxyethyl)-5-methylpiperidin-4-ylidene)hydrazine-1-carbothioamide (III) through con-den¬sation with thiosemicarbazide in acidic medium. Structures were confirmed by spectral data (IR,1H-NMR and LC-MS). Potential antimicrobial efficiency of the newly synthesized piperidin-4-one derivatives was studied against a Gram-positive bacterial strain (Staphylococcus aureus) and a Gram-negative bacterial strain (Enterobacter sp.) applying the agar dilution method. The results showed that compound (III) has a higher antimicrobial activity than compound (II).","PeriodicalId":14654,"journal":{"name":"Jordan Journal of Chemistry","volume":null,"pages":null},"PeriodicalIF":0.4000,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Synthesis and Antimicrobial Activity of Some Piperid-4-one Derivatives against Bacterial Strains\",\"authors\":\"\",\"doi\":\"10.47014/17.3.2\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"A novel compound 2-(2-ethoxyphenyl)-5-hydroxy-1-(2-hydroxyethyl)-5-methyl piperidin-4-one (II) has been synthesized by a previously well-known reaction between (E)-3-(2-ethoxyphenyl)-1-(2-methyloxiran-2-yl)prop-2-en-1-one (I) and ethanol amine. The compound was used to synthesize (Z)-2-((2S,5S)-2-(2-ethoxyphenyl)-5-hydroxy-1-(2-hydroxyethyl)-5-methylpiperidin-4-ylidene)hydrazine-1-carbothioamide (III) through con-den¬sation with thiosemicarbazide in acidic medium. Structures were confirmed by spectral data (IR,1H-NMR and LC-MS). Potential antimicrobial efficiency of the newly synthesized piperidin-4-one derivatives was studied against a Gram-positive bacterial strain (Staphylococcus aureus) and a Gram-negative bacterial strain (Enterobacter sp.) applying the agar dilution method. The results showed that compound (III) has a higher antimicrobial activity than compound (II).\",\"PeriodicalId\":14654,\"journal\":{\"name\":\"Jordan Journal of Chemistry\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.4000,\"publicationDate\":\"2022-12-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Jordan Journal of Chemistry\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.47014/17.3.2\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"CHEMISTRY, MULTIDISCIPLINARY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Jordan Journal of Chemistry","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.47014/17.3.2","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"CHEMISTRY, MULTIDISCIPLINARY","Score":null,"Total":0}
Synthesis and Antimicrobial Activity of Some Piperid-4-one Derivatives against Bacterial Strains
A novel compound 2-(2-ethoxyphenyl)-5-hydroxy-1-(2-hydroxyethyl)-5-methyl piperidin-4-one (II) has been synthesized by a previously well-known reaction between (E)-3-(2-ethoxyphenyl)-1-(2-methyloxiran-2-yl)prop-2-en-1-one (I) and ethanol amine. The compound was used to synthesize (Z)-2-((2S,5S)-2-(2-ethoxyphenyl)-5-hydroxy-1-(2-hydroxyethyl)-5-methylpiperidin-4-ylidene)hydrazine-1-carbothioamide (III) through con-den¬sation with thiosemicarbazide in acidic medium. Structures were confirmed by spectral data (IR,1H-NMR and LC-MS). Potential antimicrobial efficiency of the newly synthesized piperidin-4-one derivatives was studied against a Gram-positive bacterial strain (Staphylococcus aureus) and a Gram-negative bacterial strain (Enterobacter sp.) applying the agar dilution method. The results showed that compound (III) has a higher antimicrobial activity than compound (II).