Mono-/Bivalent Cationic Lipoamino Acids and Atypical Lipopeptides Based on Symmetric Diethanolamine Esters

In this paper, we describe the synthesis of cationic amphiphiles based on aliphatic and aromatic amino acids and diethanolamine derivatives. The calculation of the hydrophilic-lipophilic balance for a number of structures makes it possible to identify the structures with potential antimicrobial activity against gram-positive and gram-negative bacterial strains. The schemes for the synthesis of mono/bivalent cationic lipoamino acids and lipopeptides are developed. Two series of amphiphiles are obtained in preparative quantities for subsequent microbiological studies and determining the minimum inhibitory concentration.