{"title":"B12依赖性光感受器蛋白作为材料合成生物学的新兴工具","authors":"Hong Kiu Francis Fok , Fei Sun","doi":"10.1016/j.smaim.2022.03.004","DOIUrl":null,"url":null,"abstract":"<div><p>Controlling biomolecular interactions with light has gained traction among biomedical researchers due to its high spatiotemporal precision. Although a variety of photoresponsive chemical moieties are readily available thanks to the efforts made by chemists, genetically encoded photoswitches, also known as optogenetic tools, that are compatible with complex biological systems remain highly desirable. Recently, detailed mechanistic studies of the B<sub>12</sub>-dependent bacterial photoreceptor CarH have provided researchers with some new approaches to materials synthetic biology. Further development of this emerging molecular tool will continue to benefit future materials science and optogenetics.</p></div>","PeriodicalId":22019,"journal":{"name":"Smart Materials in Medicine","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S259018342200014X/pdfft?md5=554c6a99c95d4cd548c7dc7647188dc2&pid=1-s2.0-S259018342200014X-main.pdf","citationCount":"1","resultStr":"{\"title\":\"B12-dependent photoreceptor protein as an emerging tool for materials synthetic biology\",\"authors\":\"Hong Kiu Francis Fok , Fei Sun\",\"doi\":\"10.1016/j.smaim.2022.03.004\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>Controlling biomolecular interactions with light has gained traction among biomedical researchers due to its high spatiotemporal precision. Although a variety of photoresponsive chemical moieties are readily available thanks to the efforts made by chemists, genetically encoded photoswitches, also known as optogenetic tools, that are compatible with complex biological systems remain highly desirable. Recently, detailed mechanistic studies of the B<sub>12</sub>-dependent bacterial photoreceptor CarH have provided researchers with some new approaches to materials synthetic biology. Further development of this emerging molecular tool will continue to benefit future materials science and optogenetics.</p></div>\",\"PeriodicalId\":22019,\"journal\":{\"name\":\"Smart Materials in Medicine\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2022-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.sciencedirect.com/science/article/pii/S259018342200014X/pdfft?md5=554c6a99c95d4cd548c7dc7647188dc2&pid=1-s2.0-S259018342200014X-main.pdf\",\"citationCount\":\"1\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Smart Materials in Medicine\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S259018342200014X\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"Engineering\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Smart Materials in Medicine","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S259018342200014X","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"Engineering","Score":null,"Total":0}
B12-dependent photoreceptor protein as an emerging tool for materials synthetic biology
Controlling biomolecular interactions with light has gained traction among biomedical researchers due to its high spatiotemporal precision. Although a variety of photoresponsive chemical moieties are readily available thanks to the efforts made by chemists, genetically encoded photoswitches, also known as optogenetic tools, that are compatible with complex biological systems remain highly desirable. Recently, detailed mechanistic studies of the B12-dependent bacterial photoreceptor CarH have provided researchers with some new approaches to materials synthetic biology. Further development of this emerging molecular tool will continue to benefit future materials science and optogenetics.