用接触测温法估算肿瘤几何和热物理性质的一种计算方法

IF 0.8 4区 医学 Q4 ENGINEERING, BIOMEDICAL Journal of Medical Devices-Transactions of the Asme Pub Date : 2021-09-01 DOI:10.1115/1.4051517
N. Sudarsan, K. Arathy, Linta Antony, R. S. Sudheesh, M. N. Muralidharan, B. Satheesan, Seema Ansari
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引用次数: 2

摘要

接触式测温是使用与介质接触的传感器测量表面温度。这些表面温度可能是任何异常的潜在指标,可能是肿瘤。本研究工作旨在提出一种利用接触测温来估计乳腺肿瘤的几何中心、大小和热物理性质的计算方法。可佩戴的热传感器从离散的点位置捕获实时表面温度读数。采用正向传热分析法,对整个区域的连续热分布进行了公式化。该优化方法估计了乳腺的肿瘤参数,并根据估计的参数建立了三维热模型。在乳腺模型上进行了实验室实验,验证了该估计方法。此外,记录人类受试者的实时体温读数,然后将估计的位置和大小与乳房X光检查结果进行比较。发现估计的二维几何中心和肿瘤的直径大小与乳房X光检查结果非常吻合。此外,使用所提出的方法估计的热物理性质在患有肿瘤的受试者中具有更高的阶数,使其成为乳腺癌症筛查的工具。
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A Computational Method for the Estimation of the Geometrical and Thermophysical Properties of Tumor Using Contact Thermometry
Contact thermometry is the measurement of surface temperature using sensors in contact with the medium. These surface temperatures can be potential indicators of any abnormality possibly a tumor. This research work aims to present a computation method that makes use of contact thermometry to estimate the geometric center, size, and thermophysical properties of breast tumor. Wearable thermal sensors captured real-time surface temperature readings from discrete point locations. The continuous heat distribution over the domain was formulated using forward heat transfer analysis. The optimization method estimated tumor parameters of the breast, and a three-dimensional thermal model was developed from the estimated parameters. Laboratory experiments on breast phantoms were done to validate the estimation method. Furthermore, real-time temperature readings of human subjects were recorded, and the estimated location and size were then compared with the mammogram results. It was found that the estimated two-dimensional geometric center and the size in diameter of the tumor closely match with the mammogram results. Further, the thermophysical properties estimated using the proposed method had a higher order in subjects having a tumor making it a tool for breast cancer screening.
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来源期刊
CiteScore
1.80
自引率
11.10%
发文量
56
审稿时长
6-12 weeks
期刊介绍: The Journal of Medical Devices presents papers on medical devices that improve diagnostic, interventional and therapeutic treatments focusing on applied research and the development of new medical devices or instrumentation. It provides special coverage of novel devices that allow new surgical strategies, new methods of drug delivery, or possible reductions in the complexity, cost, or adverse results of health care. The Design Innovation category features papers focusing on novel devices, including papers with limited clinical or engineering results. The Medical Device News section provides coverage of advances, trends, and events.
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