白细胞介素-8、CXCL10、CXCL11及其在成年女性亚临床甲状腺功能减退和糖尿病前期胰岛素抵抗中的作用

IF 4.2 Q1 ENDOCRINOLOGY & METABOLISM Journal of Clinical and Translational Endocrinology Pub Date : 2022-06-01 DOI:10.1016/j.jcte.2022.100299
Roxana Adriana Stoica , Nicoleta Drăgana , Robert Ancuceanu , Ovidiu Ionuț Geicu , Cristian Guja , Anca Pantea-Stoian , Damaris-Cristina Gheorghe , Raluca-Ioana Stefan-van Staden , Cristian Serafinceanu , Adrian Costache , Constantin Ionescu-Tîrgoviște
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引用次数: 0

摘要

在肥胖中,甲状腺的激素分泌从体内平衡转变为2型异稳态,以适应脂肪组织和炎症的持续改变。先前的荟萃分析表明,肥胖与甲状腺疾病、前驱糖尿病和2型糖尿病的发病风险增加有关。我们设计了一项观察性横断面研究,包括所有在门诊连续就诊16个月的女性患者。本研究旨在探讨亚临床甲状腺功能减退症(SCH)患者血清细胞因子及趋化因子水平与TSH、fT4及胰岛素抵抗(IR)指标的关系。研究纳入72名女性,中位年龄为59±17.75岁,平均BMI(身体质量指数)为31.48±6.75 kg/m2。基于趋化因子(IL-8、CXCL10、CXCL11、瘦素)、c反应蛋白、SCH的存在与否,将年龄、BMI、腹围、糖化血红蛋白(HbA1c)和抗甲状腺过氧化物酶抗体(ATPO)作为协变量,对IR指数(HOMA-IR)进行建模稳态模型评估,确定了一个与依变量(IL-8)显著相关的趋化因子。在女性亚临床甲状腺功能减退患者中,IR指数与IL-8呈负相关,但IL-8的影响很小。在我们的人群中,影响CXCL11水平的是BMI而不是TSH。CXCL10在SCH、肥胖和前驱糖尿病患者中有增加的趋势,与TSH无关。
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Interleukin-8, CXCL10, CXCL11 and their role in insulin resistance in adult females with subclinical hypothyroidism and prediabetes

In obesity, the hormonal secretion of the thyroid gland switches from homeostasis to type 2 allostasis in order to adapt to persistent modifications of adipose tissue and inflammation. Previous meta-analyses have linked obesity with an increased risk of developing thyroid diseases, prediabetes, and type 2 diabetes mellitus. We designed an observational cross-sectional study including all female patients presenting consecutively in an ambulatory clinic for 16 months. This study aimed to describe the level of serum cytokines and chemokines in relation to TSH, fT4 and insulin resistance (IR) indexes in patients with subclinical hypothyroidism (SCH). The study included 72 women with a median age of 59 ± 17.75 years, and a mean BMI (Body Mass Index) of 31.48 ± 6.75 kg/m2. Modelling homeostasis model assessment of IR indices (HOMA-IR) based on chemokines (IL-8, CXCL10, CXCL11, leptin), C-reactive protein, the presence or absence of SCH, taking into account age, BMI, abdominal circumference, glycated haemoglobin (HbA1c), and anti-thyroid peroxidase antibodies (ATPO) as covariates, identified a single chemokine that was significantly associated with the dependent variable (IL-8). IR indices are negatively associated with IL-8 in female patients with subclinical hypothyroidism, but the effect of the cytokine is minimal. BMI rather than TSH influences the level of CXCL11 in our population. CXCL10 has a tendency to increase in patients with SCH, obesity and prediabetes, with no association with TSH.

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发文量
24
审稿时长
16 weeks
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