{"title":"印度东部(奥里萨邦)山羊中最近暴发的口蹄疫的分子特征、比较和进化分析","authors":"Basanta Pravas Sahu , Prativa Majee , Anjan Sahoo , Debasis Nayak","doi":"10.1016/j.aggene.2019.100088","DOIUrl":null,"url":null,"abstract":"<div><p><span>Contagious ecthyma is a zoonotic disease, caused by the Orf virus (ORFV) affecting sheep, goats, and humans and is widely distributed across the world. In this study, we have investigated fifteen recent ORFV outbreaks in Black Bengal goats occurred in the Odisha state of India. The outbreaks were characterized by the high rates of morbidity (reaching up to 100%) without any mortality in the infected goats. Molecular and </span>phylogenetic analysis<span><span> of four ORFV genes such as ORFV011, ORFV020, ORFV059, and ORFV108 was performed, which revealed that current isolates were closely related to Assam, China, Bangalore, and Meghalaya isolates, respectively, with some unique mutations. Finally, to get an insight into the global ORFV evolution pattern, population genetics parameters such as nucleotide diversity, haplotype diversity, selection pressure, and neutrality among these genes were estimated by comparing the GenBank database. We observed low haplotype as well as nucleotide diversity and </span>purifying selection implying ORFV evolution globally.</span></p></div>","PeriodicalId":37751,"journal":{"name":"Agri Gene","volume":"12 ","pages":"Article 100088"},"PeriodicalIF":0.0000,"publicationDate":"2019-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.aggene.2019.100088","citationCount":"3","resultStr":"{\"title\":\"Molecular characterization, comparative and evolutionary analysis of the recent Orf outbreaks among goats in the Eastern part of India (Odisha)\",\"authors\":\"Basanta Pravas Sahu , Prativa Majee , Anjan Sahoo , Debasis Nayak\",\"doi\":\"10.1016/j.aggene.2019.100088\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p><span>Contagious ecthyma is a zoonotic disease, caused by the Orf virus (ORFV) affecting sheep, goats, and humans and is widely distributed across the world. In this study, we have investigated fifteen recent ORFV outbreaks in Black Bengal goats occurred in the Odisha state of India. The outbreaks were characterized by the high rates of morbidity (reaching up to 100%) without any mortality in the infected goats. Molecular and </span>phylogenetic analysis<span><span> of four ORFV genes such as ORFV011, ORFV020, ORFV059, and ORFV108 was performed, which revealed that current isolates were closely related to Assam, China, Bangalore, and Meghalaya isolates, respectively, with some unique mutations. Finally, to get an insight into the global ORFV evolution pattern, population genetics parameters such as nucleotide diversity, haplotype diversity, selection pressure, and neutrality among these genes were estimated by comparing the GenBank database. We observed low haplotype as well as nucleotide diversity and </span>purifying selection implying ORFV evolution globally.</span></p></div>\",\"PeriodicalId\":37751,\"journal\":{\"name\":\"Agri Gene\",\"volume\":\"12 \",\"pages\":\"Article 100088\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2019-06-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1016/j.aggene.2019.100088\",\"citationCount\":\"3\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Agri Gene\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S235221511930008X\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"Agricultural and Biological Sciences\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Agri Gene","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S235221511930008X","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"Agricultural and Biological Sciences","Score":null,"Total":0}
Molecular characterization, comparative and evolutionary analysis of the recent Orf outbreaks among goats in the Eastern part of India (Odisha)
Contagious ecthyma is a zoonotic disease, caused by the Orf virus (ORFV) affecting sheep, goats, and humans and is widely distributed across the world. In this study, we have investigated fifteen recent ORFV outbreaks in Black Bengal goats occurred in the Odisha state of India. The outbreaks were characterized by the high rates of morbidity (reaching up to 100%) without any mortality in the infected goats. Molecular and phylogenetic analysis of four ORFV genes such as ORFV011, ORFV020, ORFV059, and ORFV108 was performed, which revealed that current isolates were closely related to Assam, China, Bangalore, and Meghalaya isolates, respectively, with some unique mutations. Finally, to get an insight into the global ORFV evolution pattern, population genetics parameters such as nucleotide diversity, haplotype diversity, selection pressure, and neutrality among these genes were estimated by comparing the GenBank database. We observed low haplotype as well as nucleotide diversity and purifying selection implying ORFV evolution globally.
Agri GeneAgricultural and Biological Sciences-Agricultural and Biological Sciences (miscellaneous)
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Agri Gene publishes papers that focus on the regulation, expression, function and evolution of genes in crop plants, farm animals, and agriculturally important insects and microorganisms. Agri Gene strives to be a diverse journal and topics in multiple fields will be considered for publication so long as their main focus is on agriculturally important organisms (plants, animals, insects, or microorganisms). Although not limited to the following, some examples of potential topics include: Gene discovery and characterization. Genetic markers to guide traditional breeding. Genetic effects of transposable elements. Evolutionary genetics, molecular evolution, population genetics, and phylogenetics. Profiling of gene expression and genetic variation. Biotechnology and crop or livestock improvement. Genetic improvement of biological control microorganisms. Genetic control of secondary metabolic pathways and metabolic enzymes of crop pathogens. Transcription analysis of beneficial or pest insect developmental stages Agri Gene encourages submission of novel manuscripts that present a reasonable level of analysis, functional relevance and/or mechanistic insight. Agri Gene also welcomes papers that have predominantly a descriptive component but improve the essential basis of knowledge for subsequent functional studies, or which provide important confirmation of recently published discoveries provided that the information is new.
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