垃圾食品对肥胖和多囊卵巢综合征的影响:机制和管理策略

Q2 Medicine Obesity Medicine Pub Date : 2023-06-01 DOI:10.1016/j.obmed.2023.100495
Rukaiah Fatma Begum, Ankul Singh S, Sumithra Mohan
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引用次数: 5

摘要

全世界妇女的肥胖率已上升至26%,少女的肥胖率为18%。BMI升高与女性的代谢和妇科问题密切相关。多囊卵巢综合征是一种严重且经常流行的与肥胖相关的合并症,表现在女孩和遗传易感的女性身上。一项横断面研究通过调查200名有或没有月经异常的女孩的月经模式、人体测量值和进食频率,调查了她们摄入几种垃圾食品的情况。研究发现,食用垃圾食品与月经困难有很大关系。垃圾食品会减缓身体的新陈代谢,减少身体燃烧的卡路里,使保持健康的体重成为一项挑战。垃圾食品通过红外线间接影响雄激素水平。胰岛素水平升高导致性激素结合球蛋白(SHBG)下降,SHBG是一种调节蛋白,可抑制雌性雄激素的活性,并在细胞因子引起IR时导致高雄激素症。现在的年轻社会和导致肥胖及其并发症的垃圾食品之间存在关联。已经证明,快速而频繁地食用垃圾食品会导致暴食和暴饮暴食,而不会达到饱腹感,也不会限制消耗的能量。肥胖和吃垃圾食品本质上与荷尔蒙有关。在全球化的时代,当有大量的快餐和久坐的生活方式导致体重增加时,多基因肥胖是最普遍的肥胖类型。一个高度整合的肠-脑神经内分泌系统通过监测能量摄入和消耗的短期和长期波动来控制食欲和体重。一些饮食方案,如生酮饮食、DASH饮食、低GI饮食等,可以更容易地大幅减少份量和额外的糖和脂肪。鉴于我们对肥胖和生殖疾病背后的潜在机制的了解,某些策略应该强调营养和生活方式的治疗和管理。
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Impact of junk food on obesity and polycystic ovarian syndrome: Mechanisms and management strategies

The prevalence of obesity among women worldwide has escalated to 26%, and among adolescent girls, it is 18%. An elevated BMI is closely associated with metabolic and gynecological issues in women. PCOS is a serious and frequently prevalent obesity-related comorbidity that manifests in girls and women genetically prone to it. A cross-sectional study examined the intake of several types of junk food in 200 girls with and without menstrual abnormalities by investigating their menstrual patterns, anthropometric measures, and eating frequency. It found that junk food consumption was substantially related to menstrual difficulties. Junk food slows down the body's metabolism and reduces the calories it burns, making it challenging to maintain a healthy weight. Junk food indirectly affects androgen levels through IR. Elevated insulin levels cause the decline of sex hormone-binding globulin (SHBG), a regulatory protein that suppresses the activity of androgens in females and causes hyperandrogenism when cytokines cause IR. There is a correlation between the current young society and junk food which lead to obesity and its complications. Its already been proven that consuming junk food rapidly and frequently results in binge and overeating without reaching satiety and limiting the amount of energy consumed. Obesity and junk eating are inherently connected with hormones. In the globalized era, when there is an abundance of fast food and sedentary lifestyles foster weight gain, polygenic obesity is the most prevalent sort of obesity. A highly integrated gut-to-brain neuroendocrine system controls appetite and body weight by monitoring both short- and long-term fluctuations in energy intake and expenditure. Several diet regimens, like the ketogenic diet, DASH diet, low GI diet, etc, make it easier to cut portion sizes and extra sugar and fat drastically. Provided our knowledge of the underlying mechanisms behind obesity and reproductive diseases, certain strategies should emphasize nutrition and lifestyle for treatment and management.

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来源期刊
Obesity Medicine
Obesity Medicine Medicine-Public Health, Environmental and Occupational Health
CiteScore
5.50
自引率
0.00%
发文量
74
审稿时长
40 days
期刊介绍: The official journal of the Shanghai Diabetes Institute Obesity is a disease of increasing global prevalence with serious effects on both the individual and society. Obesity Medicine focusses on health and disease, relating to the very broad spectrum of research in and impacting on humans. It is an interdisciplinary journal that addresses mechanisms of disease, epidemiology and co-morbidities. Obesity Medicine encompasses medical, societal, socioeconomic as well as preventive aspects of obesity and is aimed at researchers, practitioners and educators alike.
期刊最新文献
Sorghum bicolor polyphenol-rich extract improves insulin sensitivity and protect against chronic stress exacerbated diabetic nephropathy through modulation of Nrf2/NF-κB Swimming exercise regulates indices of skeletal muscle glucose metabolism and attenuates cardiac inflammatory cytokines activity via IL-6/TNF-α pathway in streptozotocin-induced diabetic rats Sestrin2 at the crossroads of cardiovascular disease and diabetes: A comprehensive review Three scientists on GLP-1 based obesity drug development are sharing 2024 Lasker-DeBakey Clinical Research Award Erratum to “Effect of low-calorie ketogenic vs low-carbohydrate diets on body composition and other biomarkers of overweight/obese women: An 8 weeks randomised controlled trial” [Obes. Med. 41C (2023) 100496]
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