LCZ-696(Sacubitril/缬沙坦)和sgl2抑制剂的使用:非洲农村心力衰竭伴射血分数降低(HFrEF)患者的真实世界经验案例系列

D. Raphael, G. Makuka, Abdu Hussein Mogella, Beatrice Kabuka, Rosemary T. Mushi, Collins Boamah
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引用次数: 0

摘要

目的:观察在难以到达的非洲农村地区,使用血管紧张素受体-奈普赖素抑制剂(ARNI)和钠-葡萄糖协同转运2抑制剂(SGLT2Ii)对心力衰竭射血分数降低(HFrEF)患者的超声心动图参数、临床症状、心血管死亡和心力衰竭住院治疗的影响。背景:与血管紧张素转换酶抑制剂或血管紧张素II受体阻滞剂相比,血管紧张素受体尼泊尔赖氨酸抑制剂(ARNI)更适合作为射血分数降低的心力衰竭患者的基础治疗,以降低心血管死亡、心力衰竭住院和心力衰竭症状的风险。SGLT2抑制剂(达格列嗪和恩帕列嗪)是治疗HFrEF的四种基础药物之一。
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Theuse of LCZ-696(Sacubitril/Valsartan) and SGLT2inhibitors: A Real World Experience in a Rural African Patient with Heart Failure with Reduced Ejection Fraction (HFrEF). A Case Series
Objective: To observe the outcomes of the use of both Angiotensin Receptor-Neprilysin inhibitor (ARNI) and sodium-glucose cotransport 2-inhibitor (SGLT2Ii) in terms of echocardiographic parameters, clinical symptoms, cardiovascular death, and Heart failure hospitalization in patient with heart failure reduced ejection fraction (HFrEF) in the hard-to-reach rural area of Africa. Background: Angiotensin Receptor-Neprilysin inhibitor (ARNI) is preferred over angiotensin-converting enzymes inhibitor or an angiotensin II receptor blocker as foundation therapy for patients with heart failure with reduced ejection fraction to reduce the risk of cardiovascular death, Heart failure hospitalization, and Heart failure symptoms. SGLT2 inhibitor (Dapagliflozin and Empagliflozin) is among the four foundation drugs in managing HFrEF.
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