Noriko Marutani, S. Akamine, D. Kanayama, S. Gotoh, K. Yanagida, Rikiya Maruyama, Kohji Mori, Tesshin Miyamoto, Hiroyoshi Adachi, Yukako Sakagami, K. Yoshiyama, Maki Hotta, Aki Nagase, J. Kozawa, N. Maeda, M. Otsuki, T. Matsuoka, H. Iwahashi, I. Shimomura, N. Murayama, Hiroshi Watanabe, Manabu Ikeda, I. Mizuta, Takashi Kudo
{"title":"血浆NfL与糖尿病患者轻度认知能力下降有关","authors":"Noriko Marutani, S. Akamine, D. Kanayama, S. Gotoh, K. Yanagida, Rikiya Maruyama, Kohji Mori, Tesshin Miyamoto, Hiroyoshi Adachi, Yukako Sakagami, K. Yoshiyama, Maki Hotta, Aki Nagase, J. Kozawa, N. Maeda, M. Otsuki, T. Matsuoka, H. Iwahashi, I. Shimomura, N. Murayama, Hiroshi Watanabe, Manabu Ikeda, I. Mizuta, Takashi Kudo","doi":"10.1111/psyg.12819","DOIUrl":null,"url":null,"abstract":"Patients with diabetes are at a higher risk for cognitive decline. Thus, biomarkers that can provide early and simple detection of cognitive decline are required. Neurofilament light chain (NfL) is a cytoskeletal protein that constitutes neural axons. Plasma NfL levels are elevated when neurodegeneration occurs. Here, we investigated whether plasma NfL levels were associated with cognitive decline in patients with type 2 diabetes.","PeriodicalId":20784,"journal":{"name":"Psychogeriatrics","volume":" ","pages":""},"PeriodicalIF":1.7000,"publicationDate":"2022-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"3","resultStr":"{\"title\":\"Plasma NfL is associated with mild cognitive decline in patients with diabetes\",\"authors\":\"Noriko Marutani, S. Akamine, D. Kanayama, S. Gotoh, K. Yanagida, Rikiya Maruyama, Kohji Mori, Tesshin Miyamoto, Hiroyoshi Adachi, Yukako Sakagami, K. Yoshiyama, Maki Hotta, Aki Nagase, J. Kozawa, N. Maeda, M. Otsuki, T. Matsuoka, H. Iwahashi, I. Shimomura, N. Murayama, Hiroshi Watanabe, Manabu Ikeda, I. Mizuta, Takashi Kudo\",\"doi\":\"10.1111/psyg.12819\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Patients with diabetes are at a higher risk for cognitive decline. Thus, biomarkers that can provide early and simple detection of cognitive decline are required. Neurofilament light chain (NfL) is a cytoskeletal protein that constitutes neural axons. Plasma NfL levels are elevated when neurodegeneration occurs. Here, we investigated whether plasma NfL levels were associated with cognitive decline in patients with type 2 diabetes.\",\"PeriodicalId\":20784,\"journal\":{\"name\":\"Psychogeriatrics\",\"volume\":\" \",\"pages\":\"\"},\"PeriodicalIF\":1.7000,\"publicationDate\":\"2022-03-13\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"3\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Psychogeriatrics\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1111/psyg.12819\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"GERIATRICS & GERONTOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Psychogeriatrics","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1111/psyg.12819","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"GERIATRICS & GERONTOLOGY","Score":null,"Total":0}
Plasma NfL is associated with mild cognitive decline in patients with diabetes
Patients with diabetes are at a higher risk for cognitive decline. Thus, biomarkers that can provide early and simple detection of cognitive decline are required. Neurofilament light chain (NfL) is a cytoskeletal protein that constitutes neural axons. Plasma NfL levels are elevated when neurodegeneration occurs. Here, we investigated whether plasma NfL levels were associated with cognitive decline in patients with type 2 diabetes.
期刊介绍：
Psychogeriatrics is an international journal sponsored by the Japanese Psychogeriatric Society and publishes peer-reviewed original papers dealing with all aspects of psychogeriatrics and related fields
The Journal encourages articles with gerontopsychiatric, neurobiological, genetic, diagnostic, social-psychiatric, health-political, psychological or psychotherapeutic content. Themes can be illuminated through basic science, clinical (human and animal) studies, case studies, epidemiological or humanistic research
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