获得性再生障碍性贫血异常免疫机制的研究进展

国际输血及血液学杂志 Pub Date : 2019-05-20 DOI:10.3760/CMA.J.ISSN.1673-419X.2019.03.012

Hui Chen

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引用次数: 0

摘要

再生障碍性贫血（AA）被认为是一种免疫介导的骨髓衰竭综合征，其特征是外周全血细胞减少和造血干/祖细胞破坏。获得性再生障碍性贫血（aAA）在临床上较为常见。异常免疫是介导aAA发病机制的主要因素之一。本文综述了目前对aAA免疫生物学的认识，以阐明该病的免疫机制，为aAA的临床治疗提供理论依据。关键词：贫血、再生障碍；免疫力；免疫抑制剂；儿童；获得性再生障碍性贫血

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Research progress of abnormal immunologic mechanism in acquired aplastic anemia

Aplastic anemia (AA) is considered as an immune-mediated bone marrow failure syndrome, characterized by peripheral pancytopenia and destruction of hematopoietic stem/progenitor cells. Acquired aplastic anemia (aAA) is more common in clinic. Abnormal immunity is one of the major factors mediating the pathogenesis of aAA. This review discusses the current understanding of the immunobiology in aAA, so as to clarify the immune mechanism of this disease, and to provide a theoretical basis for the clinical treatment of aAA. Key words: Anemia, aplastic; Immunity; Immunosuppressive agent; Children; Acquired aplastic anemia

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来源期刊

国际输血及血液学杂志

自引率

0.00%

发文量

10610

期刊介绍： The International Journal of Transfusion and Hematology was founded in September 1978. It is a comprehensive academic journal in the field of transfusion and hematology, supervised by the National Health Commission and co-sponsored by the Chinese Medical Association, West China Second Hospital of Sichuan University, and the Institute of Transfusion Medicine of the Chinese Academy of Medical Sciences. The journal is a comprehensive academic journal that combines the basic and clinical aspects of transfusion and hematology and is publicly distributed at home and abroad. The International Journal of Transfusion and Hematology mainly reports on the basic and clinical scientific research results and progress in the field of transfusion and hematology, new experiences, new methods, and new technologies in clinical diagnosis and treatment, introduces domestic and foreign research trends, conducts academic exchanges, and promotes the development of basic and clinical research in the field of transfusion and hematology.