{"title":"辣木和桑多酚在高脂肪饮食大鼠中表现出抗肥胖和抗高脂血症的作用","authors":"R. Alqurashi, Mariam Alholaibi","doi":"10.37290/ctnr2641-452x.21:102-108","DOIUrl":null,"url":null,"abstract":"This study investigated the effects of Moringa oleifera leaf, mulberry fruit, and mulberry leaf on high-fat diet-induced changes in body weight and hyperlipidemia in rats. Healthy male rats were randomly divided into five equal-sized groups that included (i) basal diet or negative control group, (ii) high-fat diet group (basal diet + 20% fat), (iii) M. oleifera leaf-treated high-fat diet group (high-fat diet + 10% M. oleifera leaf), (iv) mulberry fruit-treated high-fat diet group (high-fat diet + 10% mulberry fruit), and (v) mulberry leaf-treated high-fat diet group (high-fat diet + 10% mulberry leaf). The rats were treated daily for 6 weeks, and body weight data and blood samples were collected for each group. At the end of the study period, body weight, total cholesterol, total triglyceride, low-density lipoprotein level, and glucose level were significantly reduced in the rats fed a high-fat diet supplemented with M. oleifera leaf, mulberry fruit, or mulberry leaf. Moreover, serum high-density lipoprotein was significantly elevated in the rats on a high-fat diet receiving M. oleifera leaf or mulberry fruit. The antiobesity and antihyperlipidemic effects of M. oleifera leaf, mulberry fruit, and mulberry leaf provide support for the use of Moringa and mulberry as potential functional food ingredients for the prevention of obesity and hyperlipidemia.","PeriodicalId":10976,"journal":{"name":"Current Topics in Nutraceutical Research","volume":null,"pages":null},"PeriodicalIF":0.4000,"publicationDate":"2023-01-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Polyphenols from Moringa Oleifera and Mulberry Exhibit Anti-Obesity and Anti-Hyperlipidemic Effects in Rats Fed a High-Fat Diet\",\"authors\":\"R. Alqurashi, Mariam Alholaibi\",\"doi\":\"10.37290/ctnr2641-452x.21:102-108\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"This study investigated the effects of Moringa oleifera leaf, mulberry fruit, and mulberry leaf on high-fat diet-induced changes in body weight and hyperlipidemia in rats. Healthy male rats were randomly divided into five equal-sized groups that included (i) basal diet or negative control group, (ii) high-fat diet group (basal diet + 20% fat), (iii) M. oleifera leaf-treated high-fat diet group (high-fat diet + 10% M. oleifera leaf), (iv) mulberry fruit-treated high-fat diet group (high-fat diet + 10% mulberry fruit), and (v) mulberry leaf-treated high-fat diet group (high-fat diet + 10% mulberry leaf). The rats were treated daily for 6 weeks, and body weight data and blood samples were collected for each group. At the end of the study period, body weight, total cholesterol, total triglyceride, low-density lipoprotein level, and glucose level were significantly reduced in the rats fed a high-fat diet supplemented with M. oleifera leaf, mulberry fruit, or mulberry leaf. Moreover, serum high-density lipoprotein was significantly elevated in the rats on a high-fat diet receiving M. oleifera leaf or mulberry fruit. The antiobesity and antihyperlipidemic effects of M. oleifera leaf, mulberry fruit, and mulberry leaf provide support for the use of Moringa and mulberry as potential functional food ingredients for the prevention of obesity and hyperlipidemia.\",\"PeriodicalId\":10976,\"journal\":{\"name\":\"Current Topics in Nutraceutical Research\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.4000,\"publicationDate\":\"2023-01-11\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Current Topics in Nutraceutical Research\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.37290/ctnr2641-452x.21:102-108\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"NUTRITION & DIETETICS\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Current Topics in Nutraceutical Research","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.37290/ctnr2641-452x.21:102-108","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"NUTRITION & DIETETICS","Score":null,"Total":0}
Polyphenols from Moringa Oleifera and Mulberry Exhibit Anti-Obesity and Anti-Hyperlipidemic Effects in Rats Fed a High-Fat Diet
This study investigated the effects of Moringa oleifera leaf, mulberry fruit, and mulberry leaf on high-fat diet-induced changes in body weight and hyperlipidemia in rats. Healthy male rats were randomly divided into five equal-sized groups that included (i) basal diet or negative control group, (ii) high-fat diet group (basal diet + 20% fat), (iii) M. oleifera leaf-treated high-fat diet group (high-fat diet + 10% M. oleifera leaf), (iv) mulberry fruit-treated high-fat diet group (high-fat diet + 10% mulberry fruit), and (v) mulberry leaf-treated high-fat diet group (high-fat diet + 10% mulberry leaf). The rats were treated daily for 6 weeks, and body weight data and blood samples were collected for each group. At the end of the study period, body weight, total cholesterol, total triglyceride, low-density lipoprotein level, and glucose level were significantly reduced in the rats fed a high-fat diet supplemented with M. oleifera leaf, mulberry fruit, or mulberry leaf. Moreover, serum high-density lipoprotein was significantly elevated in the rats on a high-fat diet receiving M. oleifera leaf or mulberry fruit. The antiobesity and antihyperlipidemic effects of M. oleifera leaf, mulberry fruit, and mulberry leaf provide support for the use of Moringa and mulberry as potential functional food ingredients for the prevention of obesity and hyperlipidemia.
期刊介绍:
Current Topics in Nutraceutical Research is an international, interdisciplinary broad-based peer reviewed scientific journal for critical evaluation of research on chemistry, biology and therapeutic applications of nutraceuticals and functional foods. The major goal of this journal is to provide peer reviewed unbiased scientific data to the decision makers in the nutraceutical and food industry to help make informed choices about development of new products.
To this end, the journal will publish two types of review articles. First, a review of preclinical research data coming largely from animal, cell culture and other experimental models. Such data will provide basis for future product development and/or human research initiatives. Second, a critical evaluation of current human experimental data to help market and deliver the product for medically proven use. This journal will also serve as a forum for nutritionists, internists, neurologists, psychiatrists, and all those interested in preventive medicine.
The common denominator of all of the topic to be covered by the journal must include nutraceuticals and/functional food. The following is an example of some specific areas that may be of interest to the journal. i) Role of vitamins, minerals, antioxidants and phytonutrients on cardiovascular health, cancer, diabetes, ocular health, mental health, men’s health, women’s health, infant nutrition, ii) Role of herbals on human health, iii) Dietary supplements and sleep, iv) Components of diet that may have beneficial effect on human health, v) regulation of apoptosis and cell viability, vi) Isolation and characterization of bioactive components from functional foods, vii) Nutritional genomics, and viii) Nutritional proteomics.