亲水聚合物涂层PVC表面,减少细胞和细菌粘附

IF 1.6 Q4 ENGINEERING, BIOMEDICAL Biosurface and Biotribology Pub Date : 2022-02-06 DOI:10.1049/bsb2.12033
Rashed Almousa, Xin Wen, Sungsoo Na, Gregory Anderson, Dong Xie
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引用次数: 3

摘要

亲水聚合物在生物医学应用中非常有用。在本研究中,生物相容性聚乙二醇(PEG)和聚乙烯吡咯烷酮(PVP)聚合物被修饰或合成,末端以琥珀酰亚胺基为上限,并附着在聚氯乙烯表面。用细胞黏附和细菌黏附来评价修饰后的表面。用3T3小鼠成纤维细胞和3种细菌评价表面粘附活性。结果表明,与未改性的聚氯乙烯相比,改性后的表面明显降低了3T3细胞的粘附,PEG降低了50%-69%,PVP降低了64%-81%。与未改性的聚氯乙烯相比,改性后的聚氯乙烯表面对金黄色葡萄球菌、大肠杆菌和铜绿假单胞菌的附着率分别降低22% ~ 78%、18% ~ 76%和20% ~ 75%,PVP的附着率分别降低22% ~ 76%、18% ~ 76%和20% ~ 73%。似乎合适的链长或分子量(既不是最长的链长也不是最短的链长)决定了PEG对细胞和细菌的最低粘附。另一方面,不同链长聚合物的混合物在PVP方面表现出最低的细胞和细菌粘附。
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Hydrophilic polymer-coated PVC surface for reduced cell and bacterial adhesions

Hydrophilic polymers are very useful in biomedical applications. In this study, biocompatible polyethylene glycol (PEG) and polyvinylpyrrolidone (PVP) polymers end-capped with succinimidyl groups were either modified or synthesised and attached to polyvinylchloride surfaces. The modified surfaces were evaluated with cell adhesion and bacterial adhesion. 3T3 mouse fibroblast cells and three bacteria species were used to evaluate surface adhesion activity. Results showed that the modified surface exhibited significantly reduced 3T3 cell adhesion with a 50%–69% decrease for PEG and a 64%–81% for PVP, as compared to unmodified polyvinylchloride. The modified surface also showed significantly reduced bacterial attachment with 22%–78%, 18%–76% and 20%–75% decrease for PEG and 22%–76%, 18%–76% and 20%–73% for PVP to Staphylococcus aureus, Escherichia coli and Pseudomonas aeruginosa, respectively, as compared to unmodified polyvinylchloride. It seems that an appropriate chain length or molecular weight (neither the longest nor the shortest chain length) determines the lowest cell and bacterial adhesion in terms of PEG. On the other hand, a mixture of polymers with different chain lengths exhibited the lowest cell and bacterial adhesion in terms of PVP.

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来源期刊
Biosurface and Biotribology
Biosurface and Biotribology Engineering-Mechanical Engineering
CiteScore
1.70
自引率
0.00%
发文量
27
审稿时长
11 weeks
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