新型冠状病毒2019蛋白在药物和疫苗开发中的可能作用

Q3 Biochemistry, Genetics and Molecular Biology Journal of Applied Biotechnology Reports Pub Date : 2020-06-13 DOI:10.30491/JABR.2020.230039.1220

H. Ghaleh, Mohammad Reza Karimi, Parisa Rezayat, Masomeh Bolandian, Majid Mirzaei, Nodoushan, M. Farzanehpour

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引用次数: 2

摘要

尽管世界面临着由严重急性呼吸系统综合征冠状病毒（SARS-CoV）引起的流行病，这种疾病源于一种具有高传染性的新型冠状病毒，会导致一些人患上严重疾病，甚至可能导致死亡，目前还没有提供疫苗或特殊有效的治疗方法。通过注意到中东呼吸综合征冠状病毒（MERS）和严重急性呼吸系统综合征冠状病毒2型之间的基因相似性，特别是严重急性呼吸综合征病毒2型和严重急性呼吸道综合征冠状病毒之间的基因类似性，核衣壳（N）和病毒中的其他蛋白质及其在进入宿主细胞、病毒复制和生产中的功能，以及通过靶向上述蛋白质开发有效治疗这种冠状病毒感染的可能药物。另一方面，研究人员正在寻找一种可能的疫苗，通过使用这种病毒的蛋白质来预防感染这种病毒©2020作者

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The possible role of novel coronavirus 2019 proteins in the development of drugs and vaccines

While the world has faced an epidemic disease resulted from severe acute respiratory syndrome coronavirus (SARS-CoV), a disease which has derived from a new coronavirus that has a high contagious power causing severe illness in some individuals that may even lead to death, no vaccine or special effective treatment has been offered yet By noticing the genetic similarity between Middle East respiratory syndrome coronavirus (MERS) and SARS-CoV viruses with SARS-CoV-2 and especially between SARS-CoV and SARS-CoV-2, the aim of this research was to express the proteins of the SARS-CoV-2 virus including the spike (S), nucleocapsid (N) and other proteins in the virus and their function in entering host cells, virus replication and production on one hand, and developing possible drugs that are effective in treating this coronavirus infection by targeting the above-mentioned proteins On the other hand, the researchers are looking to offer a possible vaccine to prevent infection with this virus by using the proteins of this virus © 2020 The Author(s)

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来源期刊

Journal of Applied Biotechnology Reports Biochemistry, Genetics and Molecular Biology-Biotechnology

CiteScore

1.90

自引率

0.00%

发文量

期刊介绍： The Journal of Applied Biotechnology Reports (JABR) publishes papers describing experimental work relating to all fundamental issues of biotechnology including: Cell Biology, Genetics, Microbiology, Immunology, Molecular Biology, Biochemistry, Embryology, Immunogenetics, Cell and Tissue Culture, Molecular Ecology, Genetic Engineering and Biological Engineering, Bioremediation and Biodegradation, Bioinformatics, Biotechnology Regulations, Pharmacogenomics, Gene Therapy, Plant, Animal, Microbial and Environmental Biotechnology, Nanobiotechnology, Medical Biotechnology, Biosafety, Biosecurity, Bioenergy, Biomass, Biomaterials and Biobased Chemicals and Enzymes. Journal of Applied Biotechnology Reports promotes a special emphasis on: -Improvement methods in biotechnology -Optimization process for high production in fermentor systems -Protein and enzyme engineering -Antibody engineering and monoclonal antibody -Molecular farming -Bioremediation -Immobilizing methods -biocatalysis