{"title":"铁调素的表达及其调控机制研究进展","authors":"Yanhua Wang, Li-hong Hou","doi":"10.3760/CMA.J.ISSN.1673-419X.2019.04.013","DOIUrl":null,"url":null,"abstract":"Hepcidin is a cysteine-rich antibacterial peptide synthesized and secreted by the liver, which plays a negative regulatory role in the regulation of iron balance in the body. At the same time, it can express a large amount in the immune process and participate in the body′s immune response. Hepcidin expression is affected by many factors, such as inflammation, hypoxia and signal transduction factors. Hepcidin gene expression is mainly regulated by signaling pathways, such as JAK/STAT, BMP/Smad, TLRs/MyD88, PI3K/AKT etc.. This article mainly discusses the iron metabolism, the relationship between hepcidin and iron metabolism, and its regulatory mechanisms. \n \n \nKey words: \nIron metabolism disorders; Bone morphogenetic protein 6; Signal transduction; Interleukin-6; Hepcidin","PeriodicalId":13774,"journal":{"name":"国际输血及血液学杂志","volume":"42 1","pages":"358-361"},"PeriodicalIF":0.0000,"publicationDate":"2019-07-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Research progress in expression and regulation mechanism of hepcidin\",\"authors\":\"Yanhua Wang, Li-hong Hou\",\"doi\":\"10.3760/CMA.J.ISSN.1673-419X.2019.04.013\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Hepcidin is a cysteine-rich antibacterial peptide synthesized and secreted by the liver, which plays a negative regulatory role in the regulation of iron balance in the body. At the same time, it can express a large amount in the immune process and participate in the body′s immune response. Hepcidin expression is affected by many factors, such as inflammation, hypoxia and signal transduction factors. Hepcidin gene expression is mainly regulated by signaling pathways, such as JAK/STAT, BMP/Smad, TLRs/MyD88, PI3K/AKT etc.. This article mainly discusses the iron metabolism, the relationship between hepcidin and iron metabolism, and its regulatory mechanisms. \\n \\n \\nKey words: \\nIron metabolism disorders; Bone morphogenetic protein 6; Signal transduction; Interleukin-6; Hepcidin\",\"PeriodicalId\":13774,\"journal\":{\"name\":\"国际输血及血液学杂志\",\"volume\":\"42 1\",\"pages\":\"358-361\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2019-07-20\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"国际输血及血液学杂志\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.3760/CMA.J.ISSN.1673-419X.2019.04.013\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"国际输血及血液学杂志","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.3760/CMA.J.ISSN.1673-419X.2019.04.013","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Research progress in expression and regulation mechanism of hepcidin
Hepcidin is a cysteine-rich antibacterial peptide synthesized and secreted by the liver, which plays a negative regulatory role in the regulation of iron balance in the body. At the same time, it can express a large amount in the immune process and participate in the body′s immune response. Hepcidin expression is affected by many factors, such as inflammation, hypoxia and signal transduction factors. Hepcidin gene expression is mainly regulated by signaling pathways, such as JAK/STAT, BMP/Smad, TLRs/MyD88, PI3K/AKT etc.. This article mainly discusses the iron metabolism, the relationship between hepcidin and iron metabolism, and its regulatory mechanisms.
Key words:
Iron metabolism disorders; Bone morphogenetic protein 6; Signal transduction; Interleukin-6; Hepcidin
期刊介绍：
The International Journal of Transfusion and Hematology was founded in September 1978. It is a comprehensive academic journal in the field of transfusion and hematology, supervised by the National Health Commission and co-sponsored by the Chinese Medical Association, West China Second Hospital of Sichuan University, and the Institute of Transfusion Medicine of the Chinese Academy of Medical Sciences. The journal is a comprehensive academic journal that combines the basic and clinical aspects of transfusion and hematology and is publicly distributed at home and abroad. The International Journal of Transfusion and Hematology mainly reports on the basic and clinical scientific research results and progress in the field of transfusion and hematology, new experiences, new methods, and new technologies in clinical diagnosis and treatment, introduces domestic and foreign research trends, conducts academic exchanges, and promotes the development of basic and clinical research in the field of transfusion and hematology.
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