ph样急性淋巴细胞白血病的研究进展

国际输血及血液学杂志 Pub Date : 2019-03-20 DOI:10.3760/CMA.J.ISSN.1673-419X.2019.02.010

W. Fu

{"title":"ph样急性淋巴细胞白血病的研究进展","authors":"W. Fu","doi":"10.3760/CMA.J.ISSN.1673-419X.2019.02.010","DOIUrl":null,"url":null,"abstract":"Philadelphia chromosome-like acute lymphoblastic leukemia (Ph-like ALL) is a new high-risk subtype of acute lymphoblastic leukemia (ALL) proposed in recent years. It is characterized by a gene-expression profile similar to Ph-positive ALL, involving abnormal activation of cytokine receptor and tyrosine kinase, and commonly harbor genetic alterations targeting lymphoid transcription factors, and associated with a poor prognosis. Clinical studies showed that targeted inhibitors of related signaling pathways can significantly improve the prognosis in specific patients. The research progress of Ph-like ALL is summarized in this review. \n \n \nKey words: \nPhiladelphia chromosome; Precursor cell lymphoblastic leukemia-lymphoma; Abelson murine leukemia virus; Prognosis; CRLF2 gene","PeriodicalId":13774,"journal":{"name":"国际输血及血液学杂志","volume":"42 1","pages":"143-148"},"PeriodicalIF":0.0000,"publicationDate":"2019-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Research progress of Ph-like acute lymphoblastic leukemia\",\"authors\":\"W. Fu\",\"doi\":\"10.3760/CMA.J.ISSN.1673-419X.2019.02.010\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Philadelphia chromosome-like acute lymphoblastic leukemia (Ph-like ALL) is a new high-risk subtype of acute lymphoblastic leukemia (ALL) proposed in recent years. It is characterized by a gene-expression profile similar to Ph-positive ALL, involving abnormal activation of cytokine receptor and tyrosine kinase, and commonly harbor genetic alterations targeting lymphoid transcription factors, and associated with a poor prognosis. Clinical studies showed that targeted inhibitors of related signaling pathways can significantly improve the prognosis in specific patients. The research progress of Ph-like ALL is summarized in this review. \\n \\n \\nKey words: \\nPhiladelphia chromosome; Precursor cell lymphoblastic leukemia-lymphoma; Abelson murine leukemia virus; Prognosis; CRLF2 gene\",\"PeriodicalId\":13774,\"journal\":{\"name\":\"国际输血及血液学杂志\",\"volume\":\"42 1\",\"pages\":\"143-148\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2019-03-20\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"国际输血及血液学杂志\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.3760/CMA.J.ISSN.1673-419X.2019.02.010\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"国际输血及血液学杂志","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.3760/CMA.J.ISSN.1673-419X.2019.02.010","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}

引用次数: 0

摘要

费城染色体样急性淋巴细胞白血病（Ph-like ALL）是近年来提出的一种新的急性淋巴细胞白血病高危亚型。其特征是基因表达谱类似于Ph阳性ALL，涉及细胞因子受体和酪氨酸激酶的异常激活，通常具有针对淋巴转录因子的遗传改变，并与不良预后相关。临床研究表明，相关信号通路的靶向抑制剂可以显著改善特定患者的预后。综述了类Ph ALL的研究进展。关键词：费城染色体；前体细胞淋巴细胞白血病淋巴瘤；Abelson鼠白血病病毒；预后；CRLF2基因

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文

微信好友朋友圈 QQ好友复制链接

本刊更多论文

Research progress of Ph-like acute lymphoblastic leukemia

Philadelphia chromosome-like acute lymphoblastic leukemia (Ph-like ALL) is a new high-risk subtype of acute lymphoblastic leukemia (ALL) proposed in recent years. It is characterized by a gene-expression profile similar to Ph-positive ALL, involving abnormal activation of cytokine receptor and tyrosine kinase, and commonly harbor genetic alterations targeting lymphoid transcription factors, and associated with a poor prognosis. Clinical studies showed that targeted inhibitors of related signaling pathways can significantly improve the prognosis in specific patients. The research progress of Ph-like ALL is summarized in this review. Key words: Philadelphia chromosome; Precursor cell lymphoblastic leukemia-lymphoma; Abelson murine leukemia virus; Prognosis; CRLF2 gene

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

国际输血及血液学杂志

自引率

0.00%

发文量

10610

期刊介绍： The International Journal of Transfusion and Hematology was founded in September 1978. It is a comprehensive academic journal in the field of transfusion and hematology, supervised by the National Health Commission and co-sponsored by the Chinese Medical Association, West China Second Hospital of Sichuan University, and the Institute of Transfusion Medicine of the Chinese Academy of Medical Sciences. The journal is a comprehensive academic journal that combines the basic and clinical aspects of transfusion and hematology and is publicly distributed at home and abroad. The International Journal of Transfusion and Hematology mainly reports on the basic and clinical scientific research results and progress in the field of transfusion and hematology, new experiences, new methods, and new technologies in clinical diagnosis and treatment, introduces domestic and foreign research trends, conducts academic exchanges, and promotes the development of basic and clinical research in the field of transfusion and hematology.