紫胶/酪蛋白酸酯复合纳米载体提高槲皮素的生物利用度

IF 4.6 Q1 CHEMISTRY, APPLIED Food Hydrocolloids for Health Pub Date : 2022-12-20 DOI:10.1016/j.fhfh.2022.100113
Shikha Shiromani , M.M. Patil , Ilaiyaraja Nallamuthu , Rajamanickam R , Dongzagin Singsit , T. Anand
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引用次数: 2

摘要

为了提高槲皮素的生物利用度,本研究将槲皮素(一种黄酮类化合物)用酪蛋白酸钠和紫胶的可生物降解复合聚合物进行包封。采用反溶剂沉淀法制备了槲皮素负载的紫胶-酪蛋白酸酯复合纳米颗粒(qsnp)。在最佳工艺条件(酪蛋白酸钠2.5%、紫胶2%、pH 6.8)下,纳米配合物的粒径、PDI、zeta电位和包封效率分别为222±0.19 nm、0.11、-33.6 mV和79%。利用扫描电镜(SEM)和原子力显微镜(AFM)对优化后的纳米胶体进行了形貌表征。体外模拟胃液和肠液释放研究显示槲皮素从纳米结构中持续释放。在大鼠中,单次等效剂量口服槲皮素(50 mg/kg b.wt)的qsnp相对生物利用度比悬吊形式增加18.6倍。这些结果表明,紫胶/酪蛋白酸酯基质复合材料可以作为疏水性植物化合物的口服载体,在各种食品和药物应用中具有增强的治疗性能。
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Shellac/caseinate as a composite nanocarrier for improved bioavailability of quercetin

In the present study, quercetin (a flavonoid) was encapsulated using biodegradable composite polymers of sodium caseinate and shellac for its improved bioavailability. The quercetin-loaded shellac-caseinate composite nanoparticles (QSNPs) were prepared by anti-solvent precipitation method. Under the optimal combinations of process factors (sodium caseinate 2.5%, shellac 2% and pH 6.8,) the nanocomplexes had the sizes, PDI, zeta potential and encapsulation efficiency of 222 ± 0.19 nm, 0.11, -33.6 mV and 79%, respectively. The optimised nanocolloids were characterised using SEM and AFM microscopes for morphological features. The in vitro release study in simulated gastric and intestinal fluids showed a sustained release of the quercetin from the nanostructures. In rats, the oral administration of single equivalent dosage of quercetin (50 mg/kg b.wt) showed 18.6-fold increase in the relative bioavailability for QSNPs compared to suspension form. These results suggest that the composites of shellac/caseinate matrices can be promising carrier for the oral delivery of hydrophobic phytocompounds with enhanced therapeutic properties in various foods and pharmaceutical applications.

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来源期刊
CiteScore
4.50
自引率
0.00%
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审稿时长
61 days
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