TTFields联合其他疗法治疗胶质母细胞瘤的进展:叙述性综述

Glioma Pub Date : 2022-07-01 DOI:10.4103/glioma.glioma_12_22
Yong-Wei Cao, Haibin Wu, Bin Tang, Meihua Li, Yilv Wan, Jian Duan, Jiang Xu
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引用次数: 0

摘要

胶质瘤是颅骨最常见的原发性恶性肿瘤,目前的治疗方法仍然是手术、放疗和化疗的结合。放射治疗在胶质瘤的治疗中起着重要的作用,目前分子病理学指导下的手术切除加术后放疗和化疗是原发性胶质瘤的标准治疗方案,但其放射毒性限制了其广泛应用。同时,随着肿瘤治疗电场医学领域新技术的不断发展,胶质瘤的治疗和预后也有了一定的改善。TTFields是一种非侵入性抗癌方式,由低强度(1-3 V/cm),中频(100-300 kHz)的交流电场组成,通过一系列皮肤传感器提供最佳的肿瘤部位覆盖。TTFields通过多种作用机制靶向癌细胞,包括抑制增殖、迁移和侵袭、破坏DNA修复和血管生成、抗肿瘤作用、诱导细胞凋亡和免疫原性细胞死亡。单独使用TTFields对肿瘤具有良好的治疗效果,随着免疫和靶向治疗等技术的逐步发展,TTFields与化疗、RT、免疫治疗、免疫治疗等联合使用的研究越来越多。目前胶质瘤的治疗方法包括手术、化疗、RT、免疫治疗和靶向治疗。本文将总结TTFields联合其他疗法的研究进展,为胶质母细胞瘤的治疗提供参考。
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Progress on TTFields combined with other therapies for glioblastoma treatment: A narrative review
Glioma is the most common primary malignant tumor in the skull, and the current treatment remains a combination of surgery, radiotherapy (RT), and chemotherapy. Radiation therapy plays an important role in the treatment of glioma, and currently, surgical resection under molecular pathology guidance plus postoperative radiation therapy and chemotherapy is the standard treatment protocol for primary glioma, but its widespread use is limited by its radiotoxicity. Meanwhile, with the increasing development of new technologies in the medical field of tumor treatment electric fields, there has been some improvement in the treatment and prognosis of glioma. TTFields are a noninvasive anti-cancer modality consisting of low-intensity (1–3 V/cm), medium-frequency (100–300 kHz), alternating current electric fields delivered through an array of skin sensors to provide optimal coverage of the tumor site. TTFields target cancer cells through multiple mechanisms of action, including inhibition of proliferation, migration, and invasion, disruption of DNA repair and angiogenesis, antitumor effects, induction of apoptosis, and immunogenic cell death. TTFields alone have good efficacy against tumors, and with the gradual development of technologies such as immune and targeted therapies, TTFields are now more frequently studied in combination with chemotherapy, RT, immunotherapy, and immunotherapy. At present, the treatment methods of glioma include surgery, chemotherapy, RT, immunotherapy and targeted therapy. This article will summarize the research progress of TTFields combined with other therapies to provide a reference for the treatment of glioblastoma.
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