{"title":"阿兰内酯抑制阿霉素诱导的H9c2细胞的炎症和氧化应激","authors":"Ying Yang, Tianwei Gao","doi":"10.37290/ctnr2641-452x.20:581-587","DOIUrl":null,"url":null,"abstract":"Use of alantolactone in traditional Chinese medicine has been reported in a wide variety of diseases. To explore the role of alantolactone in chronic heart failure, its effect on doxorubicin treated H9c2 cells as a model was examined. The results of our studies show doxorubicin treatment decreased cell viability, enabled induction of secretion of proinflammatory cytokines, increased expression of malondialdehyde and decreased expression of superoxide dismutase, and enabled downregulation of nuclear factor erythroid 2-related factor 2 and heme oxygenase-1 pathways. Furthermore, all the reported effects of doxorubicin were reversed by alantolactone. In conclusion, alantolactone exhibits anti-inflammatory and antioxidative effects on doxorubicin treated H9c2 cells through activation of nuclear factor erythroid 2-related factor 2/heme oxygenase-1 and inactivation of nuclear factor-kappa B pathway. Therefore, alantolactone might be a potential agent for the prevention of doxorubicin induced chronic heart failure.","PeriodicalId":10976,"journal":{"name":"Current Topics in Nutraceutical Research","volume":" ","pages":""},"PeriodicalIF":0.4000,"publicationDate":"2022-03-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Alantolactone Suppresses Inflammation and Oxidative Stress in Doxorubicin Induced H9c2 Cells\",\"authors\":\"Ying Yang, Tianwei Gao\",\"doi\":\"10.37290/ctnr2641-452x.20:581-587\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Use of alantolactone in traditional Chinese medicine has been reported in a wide variety of diseases. To explore the role of alantolactone in chronic heart failure, its effect on doxorubicin treated H9c2 cells as a model was examined. The results of our studies show doxorubicin treatment decreased cell viability, enabled induction of secretion of proinflammatory cytokines, increased expression of malondialdehyde and decreased expression of superoxide dismutase, and enabled downregulation of nuclear factor erythroid 2-related factor 2 and heme oxygenase-1 pathways. Furthermore, all the reported effects of doxorubicin were reversed by alantolactone. In conclusion, alantolactone exhibits anti-inflammatory and antioxidative effects on doxorubicin treated H9c2 cells through activation of nuclear factor erythroid 2-related factor 2/heme oxygenase-1 and inactivation of nuclear factor-kappa B pathway. Therefore, alantolactone might be a potential agent for the prevention of doxorubicin induced chronic heart failure.\",\"PeriodicalId\":10976,\"journal\":{\"name\":\"Current Topics in Nutraceutical Research\",\"volume\":\" \",\"pages\":\"\"},\"PeriodicalIF\":0.4000,\"publicationDate\":\"2022-03-22\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Current Topics in Nutraceutical Research\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.37290/ctnr2641-452x.20:581-587\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"NUTRITION & DIETETICS\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Current Topics in Nutraceutical Research","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.37290/ctnr2641-452x.20:581-587","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"NUTRITION & DIETETICS","Score":null,"Total":0}
Alantolactone Suppresses Inflammation and Oxidative Stress in Doxorubicin Induced H9c2 Cells
Use of alantolactone in traditional Chinese medicine has been reported in a wide variety of diseases. To explore the role of alantolactone in chronic heart failure, its effect on doxorubicin treated H9c2 cells as a model was examined. The results of our studies show doxorubicin treatment decreased cell viability, enabled induction of secretion of proinflammatory cytokines, increased expression of malondialdehyde and decreased expression of superoxide dismutase, and enabled downregulation of nuclear factor erythroid 2-related factor 2 and heme oxygenase-1 pathways. Furthermore, all the reported effects of doxorubicin were reversed by alantolactone. In conclusion, alantolactone exhibits anti-inflammatory and antioxidative effects on doxorubicin treated H9c2 cells through activation of nuclear factor erythroid 2-related factor 2/heme oxygenase-1 and inactivation of nuclear factor-kappa B pathway. Therefore, alantolactone might be a potential agent for the prevention of doxorubicin induced chronic heart failure.
期刊介绍：
Current Topics in Nutraceutical Research is an international, interdisciplinary broad-based peer reviewed scientific journal for critical evaluation of research on chemistry, biology and therapeutic applications of nutraceuticals and functional foods. The major goal of this journal is to provide peer reviewed unbiased scientific data to the decision makers in the nutraceutical and food industry to help make informed choices about development of new products.
To this end, the journal will publish two types of review articles. First, a review of preclinical research data coming largely from animal, cell culture and other experimental models. Such data will provide basis for future product development and/or human research initiatives. Second, a critical evaluation of current human experimental data to help market and deliver the product for medically proven use. This journal will also serve as a forum for nutritionists, internists, neurologists, psychiatrists, and all those interested in preventive medicine.
The common denominator of all of the topic to be covered by the journal must include nutraceuticals and/functional food. The following is an example of some specific areas that may be of interest to the journal. i) Role of vitamins, minerals, antioxidants and phytonutrients on cardiovascular health, cancer, diabetes, ocular health, mental health, men’s health, women’s health, infant nutrition, ii) Role of herbals on human health, iii) Dietary supplements and sleep, iv) Components of diet that may have beneficial effect on human health, v) regulation of apoptosis and cell viability, vi) Isolation and characterization of bioactive components from functional foods, vii) Nutritional genomics, and viii) Nutritional proteomics.
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