异尿素对大鼠皮肤缺血再灌注损伤的保护作用

IF 0.9 4区 生物学 Q4 PLANT SCIENCES Israel Journal of Plant Sciences Pub Date : 2021-04-22 DOI:10.1163/22238980-BJA10031
Guifang Zhou, A-Fang Li, Q. Guo, Chuanmin Song, Youwen Zhang
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引用次数: 0

摘要

皮肤缺血再灌注(I/R)损伤是危及皮瓣手术并导致器官功能障碍的严重疾病。它是由于长时间缺血后血供恢复所致。本研究旨在探讨异尿素(ISL)对大鼠皮肤缺血再灌注损伤可能的保护作用。大鼠给药剂量分别为10 mg/kg、20 mg/kg和30 mg/kg。量化ISL对I/R损伤后大鼠皮肤组织炎症、氧化应激、凋亡等各项指标的影响及对皮肤存活的影响。组织病理学分析进一步证实了ISL可提高皮肤存活率。TUNEL染色显示,它还能减少细胞凋亡。通过将MDA、SOD和GSH水平恢复到接近正常水平,发现氧化应激水平显著降低。TNF-α、IL-1β、IL-6等细胞因子水平降低,炎症水平也随之降低。在western blot分析中,ISL也导致COX-2和iNOS的显著减少。总的来说,我们的研究表明,ISL通过多种作用机制对皮肤I/R损伤有有益作用,如氧化应激、炎症和细胞凋亡的衰减。
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Protective effect of Isoliquiritigenin on skin ischemia-reperfusion injury in rats
Skin ischemia-reperfusion (I/R) injury is a serious condition that compromises skin flap surgery and leads to organ dysfunction. It arose due to restoration of blood supply after prolonged ischemia. The present study was conducted to explore the possible protective Isoliquiritigenin (ISL) on skin ischemia-reperfusion injury in rats. The ISL was administered to rats in the dose of 10 mg/kg, 20 mg/kg, and 30 mg/kg. The effect of ISL was quantified on the skin tissue of rats following the I/R injury on various indices of inflammation, oxidative stress, and apoptosis together with the effect on skin survival. ISL improves the survival of skin which is further confirmed by the histopathological analysis. It also causes a reduction of apoptosis as shown by TUNEL staining. The level of oxidative stress was found significantly reduced by restoring the MDA, SOD, and GSH levels near to normal. The level of inflammation was also decreased as suggested by reduced level of cytokines, such as TNF-α, IL-1β, and IL-6. The ISL also causes a significant reduction of COX-2 and iNOS in western blot analysis. Collectively, our study has shown a beneficial effect of ISL against skin I/R injury via multiple mechanisms of action, such as attenuation of oxidative stress, inflammation, and apoptosis.
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来源期刊
Israel Journal of Plant Sciences
Israel Journal of Plant Sciences 生物-植物科学
CiteScore
1.90
自引率
0.00%
发文量
17
审稿时长
>12 weeks
期刊介绍: The Israel Journal of Plant Sciences is an international journal of extensive scope that publishes special issues dealing with all aspects of plant sciences, including but not limited to: physiology, cell biology, development, botany, genetic
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