{"title":"关于抗癌药物依托泊苷对果蝇的作用的薄荷提取物保护特性的测试","authors":"O. N. Antosyuk, E. Bolotnik, D. V. Obvitsev","doi":"10.1080/10496475.2023.2180698","DOIUrl":null,"url":null,"abstract":"ABSTRACT The protective properties of the extract of Monarda fistulosa var. menthifolia were tested when used together with the antitumor drug etoposide on Drosophila melanogaster. 1%, 10% extracts of M. fistulosa var. menthifolia were tested, separately and together with etoposide at 800 µg kg−1 of nutrient medium. The genotoxic effect was determined using the SMART method. Cytotoxicity was determined by assessing regulated cell death (RCD). While the extract of M. fistulosa var. menthifolia at 1% (20 mg mL−1) did not show genotoxicity, and had antigenotoxicity, reducing the genetic activity of the anticancer drug etoposide, at 10% (200 mg mL−1) it showed geno- and cytotoxicity. ","PeriodicalId":35803,"journal":{"name":"Journal of Herbs, Spices and Medicinal Plants","volume":"29 1","pages":"308 - 317"},"PeriodicalIF":1.2000,"publicationDate":"2023-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Testing the Protective Properties of the Extract of Monarda Fistulosa Var. Menthifolia L. Regarding the Effect of the Anticancer Drug Etoposide on the Example of Drosophila Melanogaster\",\"authors\":\"O. N. Antosyuk, E. Bolotnik, D. V. Obvitsev\",\"doi\":\"10.1080/10496475.2023.2180698\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"ABSTRACT The protective properties of the extract of Monarda fistulosa var. menthifolia were tested when used together with the antitumor drug etoposide on Drosophila melanogaster. 1%, 10% extracts of M. fistulosa var. menthifolia were tested, separately and together with etoposide at 800 µg kg−1 of nutrient medium. The genotoxic effect was determined using the SMART method. Cytotoxicity was determined by assessing regulated cell death (RCD). While the extract of M. fistulosa var. menthifolia at 1% (20 mg mL−1) did not show genotoxicity, and had antigenotoxicity, reducing the genetic activity of the anticancer drug etoposide, at 10% (200 mg mL−1) it showed geno- and cytotoxicity. \",\"PeriodicalId\":35803,\"journal\":{\"name\":\"Journal of Herbs, Spices and Medicinal Plants\",\"volume\":\"29 1\",\"pages\":\"308 - 317\"},\"PeriodicalIF\":1.2000,\"publicationDate\":\"2023-02-20\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Herbs, Spices and Medicinal Plants\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1080/10496475.2023.2180698\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"PHARMACOLOGY & PHARMACY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Herbs, Spices and Medicinal Plants","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1080/10496475.2023.2180698","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"PHARMACOLOGY & PHARMACY","Score":null,"Total":0}
引用次数: 0
摘要
摘要:本文研究了薄荷蒙纳达提取物与抗肿瘤药物依托opo苷联合使用对黑腹果蝇的保护作用。在800µg kg - 1的营养培养基中，分别检测1%、10%薄荷提取物，并与依托泊苷一起检测。采用SMART法测定遗传毒性效应。通过评估调节细胞死亡(RCD)来确定细胞毒性。在1% (20 mg mL−1)浓度下，薄荷叶提取物无遗传毒性，具有抗遗传毒性，降低了抗癌药物etopo苷的遗传活性;在10% (200 mg mL−1)浓度下，薄荷叶提取物表现出基因毒性和细胞毒性。
Testing the Protective Properties of the Extract of Monarda Fistulosa Var. Menthifolia L. Regarding the Effect of the Anticancer Drug Etoposide on the Example of Drosophila Melanogaster
ABSTRACT The protective properties of the extract of Monarda fistulosa var. menthifolia were tested when used together with the antitumor drug etoposide on Drosophila melanogaster. 1%, 10% extracts of M. fistulosa var. menthifolia were tested, separately and together with etoposide at 800 µg kg−1 of nutrient medium. The genotoxic effect was determined using the SMART method. Cytotoxicity was determined by assessing regulated cell death (RCD). While the extract of M. fistulosa var. menthifolia at 1% (20 mg mL−1) did not show genotoxicity, and had antigenotoxicity, reducing the genetic activity of the anticancer drug etoposide, at 10% (200 mg mL−1) it showed geno- and cytotoxicity.
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The Journal of Herbs, Spices & Medicinal Plants is an essential reference filled with recent research and other valuable information associated with herbs, spices, and medicinal plants. The Journal serves as a focus point through which investigators and others may publish material of importance to the production, marketing, and utilization of these plants and associated extracts. The journal covers the following topics: growth, development, horticulture, ecology, physiology, genetics, chemistry, and economics. Original articles, review articles, and book reviews provide information of interest to an international audience of researchers, teachers, technicians, and managers involved with production and/or marketing of herbs, spices, and medicinal plants. Managers of food companies, food processing facilities, medical research laboratories, government agencies, and others interested in new chemicals, food additives, international trade, patents, and other items can easily review new findings. The Journal of Herbs, Spices & Medicinal Plants is a forum in which recent research and other information associated with herbs, spices, and medicinal plants is shared. The Journal represents a centralized database accessible by investigators within the international community that work with or have an interest in herbs, spices, and medicinal plants.
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