基于实验室的急性弛缓性麻痹监测无脊髓灰质炎前认证:印度尼西亚2003-2013年的经验

Nike Susanti, H. Herna
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Data didapat dari laboratorium jejaring laboratorium Polio di Jakarta, Bandung, Surabaya dan Sub Direktorat Surveilans, Direktorat Surveilans dan Karantina Kesehatan, Direktorat Jenderal Pencegahan dan Pengendalian Penyakit. Data di analisis menggunakan program Microsoft Excel. \nHasil: Sebanyak 305 kasus AFP yang disebabkan oleh infeksi virus polio liar tipe 1 impor ditemukan pada tahun 2005 dan 2006. Terdapat 39 kasus AFP yang disebabkan cVDPV tipe 1 ditemukan di Pulau Madura pada tahun 2005. Virus polio liar tipe 1 hanya ditemukan di pulau Sumatera dan Jawa. Penyebaran Virus polio berhasil dihentikan pada tahun 2006 dan sudah tidak ditemukan lagi hingga tahun 2013. \nKesimpulan: Surveilans AFP berbasis laboratorium yang baik berhasil memantau dan mendeteksi sirkulasi virus polio. 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引用次数: 1

摘要

背景:野生脊髓灰质炎病毒会导致瘫痪和免疫抑制。为了监测野生脊髓灰质炎病毒的传播,实行监控急性黄疸麻痹症(AFP)和自1995年以来在印尼开展的实验室调查。最后一种独立的野生脊髓灰质炎病毒于1995年在印度尼西亚被发现。印度尼西亚仍然对地方病国家的野生脊髓灰质炎病毒和变异脊髓灰质炎病毒构成威胁,该病毒从一种疫苗中释放出与野生脊髓灰质炎病毒相同的瘫痪。本文的目的是概述2008 -2013年印尼基于实验室的监控,从而在2014年为印度尼西亚提供免费脊髓灰质炎国家。方法:分析数据是2008 -2013年印尼国内AFP病例的数据。数据来自雅加达、万隆、泗水和副监察、监察与健康检疫、疾病预防与控制总局的脊髓灰质炎网络实验室。使用微软Excel程序进行分析的数据。结果:2005年和2006年,由野生1型脊髓灰质炎病毒感染引起的305例AFP病例被发现。2005年在马杜拉岛发现了39例由cVDPV第一型病毒引起的AFP病例。1型野生脊髓灰质炎病毒只在苏门答腊和爪哇岛发现。脊髓灰质炎病毒在2006年被成功阻止,直到2013年才被发现。结论:基于实验室的监控系统能够检测和检测脊髓灰质炎病毒的循环。需要提高监测功能,以证明小儿麻痹病毒的有效传播,以便全球根除脊髓灰质炎。关键词:监视,脊髓灰质炎实验室,急性黄疸瘫痪背景:野生多发性病毒可能导致黄疸引起免疫抑制。监视病毒传播的野生脊髓灰质炎,Acute Flaccid瘫痪者(AFP)监视实验室调查在1995年在印度尼西亚成立。最后一种未经抑制的多糖病毒在1995年在印度尼西亚发现。印度尼西亚仍然有威胁从地方性国家传播野生脊髓灰质炎病毒和息肉病毒变异的疫苗,这可能导致麻痹病毒就像野生息肉病毒一样。这篇文章的目标是描述从2008年到2013年在印尼的实验室监控,所以它在2014年获得了印尼免费脊髓灰质炎证书。方法:分析数据显示AFP cases数据来自印尼各个省2012 -2014期。数据来自雅加达、万隆、泗水和调查潜艇主任、监测和健康检疫主任、疾病预防和控制主任。数据是对微软Excel程序进行分析。推荐:305病虫害养病养病于2005年和2006年被发现。39型cVDPV感染追踪器于2005年还在马杜拉岛发现。型号1病毒只在苏门答腊和爪哇岛发现。未运输的多发性病毒在2006年被终止,直到2013年才找到。结论:改进的AFP监控表现需要证明多发性病毒传播的结果,所以多发性病毒的根除可以实现全球。监视,实验室小儿麻痹症,急性黄疸
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Laboratory-based Acute Flaccid Paralysis surveillance pre-polio free certification: Indonesia experience, 2003-2013
Latar belakang: Virus Polio Liar dapat menyebabkan kelumpuhan dan dapat dicegah dengan imunisasi. Untuk memonitor transmisi virus polio liar dilakukan surveilans Acute Flaccid Paralysis (AFP) dan investigasi laboratorium yang telah dimulai sejak tahun 1995 di Indonesia. Virus polio liar Indigenous terakhir ditemukan di Indonesia tahun 1995. Indonesia masih memiliki ancaman importasi virus polio liar dari negara endemis dan mutasi virus polio dari vaksin yang menyebakan kelumpuhan yang sama seperti virus polio liar. Artikel ini bertujuan untuk memberikan gambaran mengenai surveilans AFP berbasis laboratorium di Indonesia pada tahun 2003-2013 sehingga mengantarkan Indonesia sebagai negara bebas polio pada tahun 2014. Metode: Data yang dianalisis adalah data kasus AFP seluruh Indonesia periode tahun 2003-2013. Data didapat dari laboratorium jejaring laboratorium Polio di Jakarta, Bandung, Surabaya dan Sub Direktorat Surveilans, Direktorat Surveilans dan Karantina Kesehatan, Direktorat Jenderal Pencegahan dan Pengendalian Penyakit. Data di analisis menggunakan program Microsoft Excel. Hasil: Sebanyak 305 kasus AFP yang disebabkan oleh infeksi virus polio liar tipe 1 impor ditemukan pada tahun 2005 dan 2006. Terdapat 39 kasus AFP yang disebabkan cVDPV tipe 1 ditemukan di Pulau Madura pada tahun 2005. Virus polio liar tipe 1 hanya ditemukan di pulau Sumatera dan Jawa. Penyebaran Virus polio berhasil dihentikan pada tahun 2006 dan sudah tidak ditemukan lagi hingga tahun 2013. Kesimpulan: Surveilans AFP berbasis laboratorium yang baik berhasil memantau dan mendeteksi sirkulasi virus polio. Peningkatan kinerja surveillance AFP diperlukan untuk membuktikan terhentinya transmisi virus polio sehingga eradikasi polio secara global dapat diraih.  Kata kunci: surveilans, laboratorium polio, Acute Flaccid Paralysis   Abstract Background: Wild Poliovirus can cause flaccid paralysis and can be prevented by immunization. To monitor wild polio virus transmission, Acute Flaccid Paralysis (AFP) surveillance and laboratory investigations was initiated in 1995 in Indonesia. The last indigenous wild poliovirus found at 1995 in Indonesia. Indonesia still has the threat of imported wild polio viruses from endemic countries and poliovirus mutation from vaccine that can cause paralytic as well as wild poliovirus. The aim of this article is to describe the laboratory-based AFP surveillance in Indonesia from 2003-2013 so that it had led the Indonesia certified for polio free in 2014. Methods: Data analysis performed on AFP cases data from all provinces in Indonesia period of 2013-2014. Data were collected from polio laboratories network in Jakarta, Bandung, Surabaya and the Sub Directorate of Surveillance, Directorate of Surveillance and Health Quarantine, Directorate General of Disease Prevention and Control. Data were analyzed using Microsoft Excel program. Results: 305 paralysis cases were caused by imported type 1 wild poliovirus infection were found in 2005 and 2006. 39 paralysis cases caused by type 1 cVDPV infection were also found on Madura Island in 2005. Type 1 wild polioviruses only found on the Sumatra and Java island. The wild poliovirus transmission was stopped in 2006 and was no longer found until 2013. Conclusion: Good laboratory-based AFP surveillance has been successfully monitoring and detecting the circulation of the poliovirus. Improved AFP surveillance performance is needed to prove cessation of poliovirus transmission so that eradication of poliovirus can be achieved globally. Keywords: surveillance, polio laboratory, Acute Flaccid Paralysis
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