蜂王浆消耗对脂质分布的影响：GRADE评估的系统评价和剂量反应Meta分析

IF 2.4 Q3 NUTRITION & DIETETICS PharmaNutrition Pub Date : 2023-09-01 DOI:10.1016/j.phanu.2023.100351

Hossein Bahari , Shaghayegh Taheri , Mohammad Rashidmayvan , Zohreh Sajadi Hezaveh , Sara Ebrahimi Mousavi , Mahsa Malekahmadi

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引用次数: 3

摘要

背景关于蜂王浆（RJ）对心脏代谢危险因素的影响，存在不一致的证据。因此，本荟萃分析旨在确定这种影响。方法通过PubMed/Medline、Web of Science和SCOPUS进行数据库搜索，直到2023年4月，以确定符合条件的试验。通过随机效应模型，甘油三酯（TG）、总胆固醇（TC）、高密度脂蛋白胆固醇（HDL）和低密度脂蛋白（LDL）采用95%置信度（CI）和加权平均差（WMD）。结果RJ可显著降低TC（WMD:−8.75；95%可信区间：−15.50，−1.99；P=0.01；I2=68.5%；P异质性=0.21）。RJ对血清TC的保护作用在不健康参与者、补充用药≥8周、RJ≥3000mg/d以及男女中均较强。所有研究组合和亚组分析均未显示这种补充剂对TG、LDL和HDL的显著影响。剂量反应分析显示，在补充更高剂量的RJ后，HDL的降低幅度更大，TG的升高幅度更大。干预时间越长，LDL水平也越低。就证据的确定性而言，TG、TC和HDL被认为是中等质量的，LDL被认为是低质量的。结论sRJ可通过降低TC水平来降低心血管疾病的风险，长期补充可提高HDL和LDL水平。

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The effects of Royal Jelly consumption on lipid profile: A GRADE-assessed systematic review and dose-response meta-analysis

Background

Inconsistent evidence exists regarding the impact of Royal Jelly (RJ) on cardio-metabolic risk factors. Hence, this meta-analysis aimed to identify this effect.

Method

Database search through PubMed/Medline, Web of Science, and SCOPUS was performed until April 2023 to identify eligible trials. Estimated 95% confidence (CI) and the weighted mean difference (WMD) was used for triglyceride (TG), total cholesterol (TC), high-density lipoprotein cholesterol (HDL), and low-density lipoprotein cholesterol (LDL) through the random-effects model.

Results

RJ could significantly reduce TC (WMD: −8.75; 95%CI: −15.50, −1.99; P = 0.01; I² = 68.5%; P _{heterogeneity}= 0.21). The protective effect of RJ against serum TC was stronger in unhealthy participants, ≥ 8 weeks of supplement administration, ≥ 3000 mg/d of RJ, and in both sexes. Neither the all-study combination nor the subgroup analysis showed a significant effect of this supplementation on TG, LDL and HDL. Dose-response analysis showed a greater reduction in HDL and a greater elevation in TG, following higher doses of RJ supplementation. Longer duration of intervention also led to lower LDL levels. In terms of the certainty of the evidence, TG, TC and HDL were regarded as moderate and LDL as low quality.