喀麦隆一例非洲黑人慢性淋巴细胞白血病病例报告

R. C. Founou, J. Nwobegahay, R. Gandji, Cedrice Tsayem, Sandra Yopa, M. Kuété, Luria Leslie Founou
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摘要

慢性淋巴细胞白血病(CLL)是一种获得性单克隆疾病,其特征是功能不全的淋巴细胞逐渐积累。它通常表现为在B细胞分化途径中停滞的克隆B细胞,在形态上类似于外周血中的成熟淋巴细胞。喀麦隆等撒哈拉以南非洲国家缺乏CLL数据。我们在此报告一名54岁的非洲黑人男子的CLL病例,该病例在7年内保持稳定。该患者没有接触有毒化学物质或电离辐射的历史,并出现了一些主诉和临床症状。临床和实验室研究表明,Binet分期系统的B期出现CLL。氯胺酚的剂量使患者获得了良好的结果,减少了淋巴细胞计数和淋巴结大小,同时减轻了疼痛,改善了患者的总体状况和骨髓功能。
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Chronic Lymphocytic Leukemia in a Black African Man: A Cameroonian Case Report
Chronic lymphocytic leukemia (CLL) is an acquired monoclonal disorder characterized by a gradual accumulation of functionally incompetent lymphocytes. It generally presents a clonal B cells arrested in the B-cell differentiation pathway that resemble morphologically to mature lymphocytes in the peripheral blood. There is a scarcity of CLL data among sub-Saharan African countries such as Cameroon. We herein report a case of CLL that remained stable over a period of seven years in a 54 years old Black African man. The patient had no history of exposure to toxic chemicals or ionizing radiation and presented with several complaints and clinical symptoms. Clinical and laboratory investigations indicated a CLL in stage B of the Binet staging system. The dosage of chloraminophene led to a favourable outcome in the patient with the reduction of lymphocyte count, size of lymph nodes while relieving pain and improving general status and bone-marrow function of the patient.
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