螺-巴比妥类化合物合成策略的分类研究进展

IF 1.9 4区 化学 Q2 CHEMISTRY, ORGANIC Mini-reviews in Organic Chemistry Pub Date : 2023-04-28 DOI:10.2174/1570193x20666230428112212
D. Magoo, Anju Srivastava, Shruti Gupta, Reena Jain, Soma Mondal Ghorai, Yashna Dawer, Sumedha Sengupta, Soni Rani
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引用次数: 0

摘要

螺旋化合物是由单个原子连接的多环体系,具有独特的三维结构,在合成化学、药物化学、药理学、材料科学和物理学等领域占有重要地位。将巴比妥环衍生物纳入螺环结构的螺比妥酸酯化合物已成为药物发现的有吸引力的合成靶标,因为它们具有广泛的药理应用。在这篇综述中,我们旨在以分类的方式揭示广泛的、当代的研究应用于合成不同环尺寸(3,5,6和7元)的不同螺巴比妥酸盐。它介绍了报道的合成方法,以及它们的机制途径,以及一些这些合成的生物显著基序的药理活性。
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Developments in Synthesis Strategies of Spiro-Barbiturate compounds: A Classified Study
Spiro compounds being multi-cyclic systems linked by a single atom, have distinct three dimensionalities, and prominently hold a position of interest in the fields of synthetic and medicinal chemistry, pharmacology, material sciences and physics. Spirobarbiturate compounds which incorporate barbituric ring derivatives into spirocyclic structures have emerged as attractive synthetic targets for drug discovery as they are known to exhibit far-ranging pharmacological applications. In this review, we aim to bring to light the extensive, contemporary research applied to the synthesis of different spirobarbiturates having varied ring sizes (3, 5, 6 and 7 membered) in a classified manner. It presents the reported methods of synthesis along with their mechanistic pathways as well as the pharmacological activities of some of these synthesized biologically significant motifs.
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来源期刊
Mini-reviews in Organic Chemistry
Mini-reviews in Organic Chemistry 化学-有机化学
CiteScore
4.50
自引率
4.30%
发文量
116
审稿时长
>12 weeks
期刊介绍: Mini-Reviews in Organic Chemistry is a peer reviewed journal which publishes original reviews on all areas of organic chemistry including organic synthesis, bioorganic and medicinal chemistry, natural product chemistry, molecular recognition, and physical organic chemistry. The emphasis will be on publishing quality papers very rapidly, without any charges. The journal encourages submission of reviews on emerging fields of organic chemistry including: Bioorganic Chemistry Carbohydrate Chemistry Chemical Biology Chemical Process Research Computational Organic Chemistry Development of Synthetic Methodologies Functional Organic Materials Heterocyclic Chemistry Macromolecular Chemistry Natural Products Isolation And Synthesis New Synthetic Methodology Organic Reactions Organocatalysis Organometallic Chemistry Theoretical Organic Chemistry Polymer Chemistry Stereochemistry Structural Investigations Supramolecular Chemistry
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