B. Sekar, R. Saranyan, R. Nirmal, Indrapriyadharshini Kumaresan, A. Murugesan, L. Kamaraj
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Caldesmon Expression in Metastatic and Non-Metastatic Oral Squamous Cell Carcinoma—A Mediator of Epithelial Mesenchymal Transition
Introduction: For the past decades long-term survival of oral squamous cell carcinoma (OSCC) patients remain unchanged which provides a wide platform for research. Caldesmon (CaD), an actin-myosin binding protein, has a contributing role in cytoskeleton modulation and cell motility. The aim of this study is to evaluate the expression of CaD in metastatic and non-metastatic OSCC and to discuss the possible role of CaD in epithelial mesenchymal transition. Materials and Methods: Archival blocks of 25 metastatic and 25 non-metastatic OSCC patients are included where CaD expression is evaluated immunohistochemically. Results: Overall expression and staining intensity of CaD were statistically significant in different grades of metastatic and non-metastatic OSCC. In summary, high expression of CaD is observed in increasing grades of OSCC but the metastatic potential of the tumour doesn’t seem to have any relation with CaD.
期刊介绍：
Journal of Orofacial Sciences is dedicated to noblest profession of Dentistry, and to the young & blossoming intellects of dentistry, with whom the future of dentistry will be cherished better. The prime aim of this journal is to advance the science and art of dentistry. This journal is an educational tool to encourage and share the acquired knowledge with our peers. It also to improves the standards and quality of therauptic methods. This journal assures you to gain knowledge in recent advances and research activities. The journal publishes original scientific papers with special emphasis on research, unusual case reports, editorial, review articles, book reviews & other relevant information in context of high professional standards.
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