大鼠和人盲肠和阑尾的组织学特征比较

V. Hryn
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引用次数: 0

摘要

背景近年来,在研究人类和哺乳动物,特别是大白鼠的消化道组织结构方面出现了新的方向,因为非近交系大白鼠是在实验条件下复制人类病理学以及新药临床前测试的主要模型。客观的通过文献分析对大鼠和人盲肠和阑尾组织学特征的比较研究。材料和方法。书目分析基于已发表的同行评审文章、书籍、教科书、专著、论文摘要。为了进行系统综述,在互联网、本地文献来源、波尔塔瓦国立医科大学科学和电子图书馆中使用以下关键词进行了文献检索(关于盲肠和阑尾组织结构的研究):“组织学”、“微观结构”、“消化系统”、“盲肠”、“阑尾”,“小白鼠”,“老鼠解剖学”。后果就其组织结构而言,大白鼠胃肠道粘膜与人类胃肠道粘膜足够相似,可以作为消化系统某些病理条件的实验建模对象。结论。已经发现大白鼠盲肠粘膜中淋巴结的浓度增加。在大鼠和人类中,人类的盲肠和阑尾具有相同的免疫防御结构,它们共同代表了消化道粘膜的免疫系统。
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HISTOLOGICAL FEATURES OF THE CECUM AND VERMIFORM APPENDIX IN RATS AND HUMANS: COMPARATIVE ASPECTS
Background. In recent years, there have emerged new directions in the study of the histological structure of the digestive tract in humans and mammals and, in particular, white rats, since non-inbred white rats are the main model for reproducing human pathology under experimental conditions as well as for preclinical testing of new drugs. Objective. A comparative study of the histological features of the cecum and appendix in rats and humans by means of bibliographic analysis. Material and methods. Bibliographic analysis is based on published peer-reviewed articles, books, textbooks, monographs, dissertation abstracts. For the purposes of a systematic review, the literature search (concerning the study of the histological structure of the cecum and appendix) was carried out on the Internet, in native literature sources, the scientific and electronic library of Poltava State Medical University using the following keywords: “histology”, “microscopic structure”, "digestive system", "cecum", "appendix", "white rats", "rat anatomy". Results. The mucous membrane of the gastrointestinal tract of white rats, in terms of its histological structure, is similar enough to that of humans to serve as an object in the experimental modeling of certain pathological conditions of the digestive system. Conclusions. There has been found an increased concentration of lymphoid nodules in cecal mucosa of white rats. In white rats and humans, the cecum and the appendix in humans are endowed with the same immune defense structures, which together represent the immune system of the digestive tract mucosa.
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