肠道菌群在治疗阿尔茨海默病中的作用

Gut microbiome (Cambridge, England) Pub Date : 2023-06-19 eCollection Date: 2023-01-01 DOI:10.1017/gmb.2023.8
Sabrina Sehn Hilgert, Daniel Penteado Martins Dias
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引用次数: 0

摘要

对肠道微生物群及其对我们机体影响的理解的演变使其成为针对不仅影响肠道而且影响神经通路和中枢神经系统本身的疾病的治疗的潜在主角。这项研究,从一个彻底的系统回顾发展,试图证明干预对阿尔茨海默病患者肠道微生物群的影响。使用不同种类益生菌的临床试验描述了显著的症状缓解,其测量是基于使用益生菌之前,期间和之后的筛选和评分,允许观察患者功能和症状的变化。另一方面,粪便微生物群移植需要通过临床试验进一步验证,尽管从症状学的角度来看,它已经在案例研究中被报道为有希望的。目前的研究汇编使证明肠道微生物群对阿尔茨海默病病理的潜在影响成为可能。然而,需要更多参与者的新临床研究来进一步阐明病理生理相关性。
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The intestinal microbiota as an ally in the treatment of Alzheimer's disease.

The evolution of the understanding of the intestinal microbiota and its influence on our organism leverages it as a potential protagonist in therapies aimed at diseases that affect not only the intestine but also neural pathways and the central nervous system itself. This study, developed from a thorough systematic review, sought to demonstrate the influence of the intervention on the intestinal microbiota in subjects with Alzheimer's disease. Clinical trials using different classes of probiotics have depicted noteworthy remission of symptoms, whose measurement was performed based on screenings and scores applied before, during, and after the period of probiotics use, allowing the observation of changes in functionality and symptomatology of patients. On the other hand, faecal microbiota transplantation requires further validation through clinical trials, even though it has already been reported in case studies as promising from the symptomatology point of view. The current compilation of studies made it possible to demonstrate the potential influence of the intestinal microbiota on Alzheimer's pathology. However, new clinical studies with a larger number of participants are needed to obtain further clarification on pathophysiological correlations.

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