单剂量老化大蒜提取物不会改变心血管危险因素老年人的脑氧合和血容量

IF 2.4 Q3 NUTRITION & DIETETICS PharmaNutrition Pub Date : 2023-09-01 DOI:10.1016/j.phanu.2023.100345
Mônica Volino-Souza , Gustavo Vieira de Oliveira , Renata Leitão , Leandro Lara de Carvalho , Thiago da Silveira Alvares
{"title":"单剂量老化大蒜提取物不会改变心血管危险因素老年人的脑氧合和血容量","authors":"Mônica Volino-Souza ,&nbsp;Gustavo Vieira de Oliveira ,&nbsp;Renata Leitão ,&nbsp;Leandro Lara de Carvalho ,&nbsp;Thiago da Silveira Alvares","doi":"10.1016/j.phanu.2023.100345","DOIUrl":null,"url":null,"abstract":"<div><h3>Background</h3><p><span>and Aims: Ageing is associated with impaired endothelial function, which can negatively affect cerebral blood flow (CBF). The present study evaluated whether aged garlic extract (AGE) could improve cerebral </span>oxygenation<span><span> and blood volume due to the possible vasoactive effect. Methods and Results: Fourteen older adults were enrolled in a randomized, double-blind, cross-over study. Urinary </span>thiosulfate<span> and plasma nitrite was drawn, and participants ingested 2.4 g of AGE or placebo. A handgrip exercise protocol started 180 min after supplementation to induce brain activation, and cerebral oxygenation and blood volume were evaluated by near-infrared spectroscopy. After exercise, urinary thiosulfate and plasma nitrite were re-evaluated. AGE supplementation did not change cerebral oxygenation and blood volume. In addition, urinary thiosulfate and plasma nitrite remained unchanged after supplementation. Conclusion: A single dose of AGE (2.4 g) could not increase nitrite levels and cerebral oxygenation and blood volume in older adults at cardiovascular risk factors (NCT04008693).</span></span></p></div>","PeriodicalId":20049,"journal":{"name":"PharmaNutrition","volume":"25 ","pages":"Article 100345"},"PeriodicalIF":2.4000,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"A single dose of aged garlic extract did not change cerebral oxygenation and blood volume in older adults at cardiovascular risk factors\",\"authors\":\"Mônica Volino-Souza ,&nbsp;Gustavo Vieira de Oliveira ,&nbsp;Renata Leitão ,&nbsp;Leandro Lara de Carvalho ,&nbsp;Thiago da Silveira Alvares\",\"doi\":\"10.1016/j.phanu.2023.100345\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Background</h3><p><span>and Aims: Ageing is associated with impaired endothelial function, which can negatively affect cerebral blood flow (CBF). The present study evaluated whether aged garlic extract (AGE) could improve cerebral </span>oxygenation<span><span> and blood volume due to the possible vasoactive effect. Methods and Results: Fourteen older adults were enrolled in a randomized, double-blind, cross-over study. Urinary </span>thiosulfate<span> and plasma nitrite was drawn, and participants ingested 2.4 g of AGE or placebo. A handgrip exercise protocol started 180 min after supplementation to induce brain activation, and cerebral oxygenation and blood volume were evaluated by near-infrared spectroscopy. After exercise, urinary thiosulfate and plasma nitrite were re-evaluated. AGE supplementation did not change cerebral oxygenation and blood volume. In addition, urinary thiosulfate and plasma nitrite remained unchanged after supplementation. Conclusion: A single dose of AGE (2.4 g) could not increase nitrite levels and cerebral oxygenation and blood volume in older adults at cardiovascular risk factors (NCT04008693).</span></span></p></div>\",\"PeriodicalId\":20049,\"journal\":{\"name\":\"PharmaNutrition\",\"volume\":\"25 \",\"pages\":\"Article 100345\"},\"PeriodicalIF\":2.4000,\"publicationDate\":\"2023-09-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"PharmaNutrition\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S2213434423000178\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"NUTRITION & DIETETICS\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"PharmaNutrition","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2213434423000178","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"NUTRITION & DIETETICS","Score":null,"Total":0}
引用次数: 0

摘要

背景和目的:衰老与内皮功能受损有关,内皮功能受损会对脑血流量产生负面影响。本研究评估了老化大蒜提取物(AGE)是否因其可能的血管活性作用而改善脑氧合和血容量。方法和结果:14名老年人参加了一项随机、双盲、交叉研究。抽取尿硫代硫酸盐和血浆亚硝酸盐,参与者摄入2.4克AGE或安慰剂。在补充后180分钟开始抓握运动方案,以诱导大脑激活,并通过近红外光谱评估大脑氧合和血容量。运动后,对尿硫代硫酸盐和血浆亚硝酸盐进行重新评估。补充AGE不会改变脑氧合和血容量。此外,补充后尿硫代硫酸盐和血浆亚硝酸盐保持不变。结论:单剂量AGE(2.4g)不能增加心血管危险因素老年人的亚硝酸盐水平、脑氧合和血容量(NCT04008693)。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
A single dose of aged garlic extract did not change cerebral oxygenation and blood volume in older adults at cardiovascular risk factors

Background

and Aims: Ageing is associated with impaired endothelial function, which can negatively affect cerebral blood flow (CBF). The present study evaluated whether aged garlic extract (AGE) could improve cerebral oxygenation and blood volume due to the possible vasoactive effect. Methods and Results: Fourteen older adults were enrolled in a randomized, double-blind, cross-over study. Urinary thiosulfate and plasma nitrite was drawn, and participants ingested 2.4 g of AGE or placebo. A handgrip exercise protocol started 180 min after supplementation to induce brain activation, and cerebral oxygenation and blood volume were evaluated by near-infrared spectroscopy. After exercise, urinary thiosulfate and plasma nitrite were re-evaluated. AGE supplementation did not change cerebral oxygenation and blood volume. In addition, urinary thiosulfate and plasma nitrite remained unchanged after supplementation. Conclusion: A single dose of AGE (2.4 g) could not increase nitrite levels and cerebral oxygenation and blood volume in older adults at cardiovascular risk factors (NCT04008693).

求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
PharmaNutrition
PharmaNutrition Agricultural and Biological Sciences-Food Science
CiteScore
5.70
自引率
3.10%
发文量
33
审稿时长
12 days
期刊最新文献
A therapeutic approach to identify leading molecules from natural products and therapeutic targets in CKD by network pharmacology Efficacy and safety of crocin supplementation in patients with central serous chorioretinopathy, a pilot randomized double blinded clinical trial Dietitians’ knowledge and practice regarding inflammaging and related interventions: A pilot survey Exploring the molecular mechanisms and therapeutic benefits of L-theanine in counteracting inflammation Enhanced absorption of omega-3 fatty acids from a novel krill oil-derived phospholipid formulation compared to fish oil ethyl esters: A randomized, two-way crossover pharmacokinetic study
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1