组织工程用短肽基多糖水凝胶综述

IF 1.3 4区农林科学 Q2 MATERIALS SCIENCE, PAPER & WOOD Cellulose Chemistry and Technology Pub Date : 2023-07-20 DOI:10.35812/cellulosechemtechnol.2023.57.41

Song Jiang, Yue Liu, Yuan Gu

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引用次数: 0

摘要

综述了短肽基多糖水凝胶在组织工程中的应用。它解释了使用短肽基多糖水凝胶作为组织再生支架的缺点，同时强调了它们的优点。在这篇综述中，我们首先简要概述了基于短肽的多糖水凝胶的设计过程。然后，我们提供了具有分类多糖（透明质酸、葡聚糖、壳聚糖、藻酸盐和琼脂糖）的水凝胶的额外详细信息。我们还解释了生物活性短肽Arg-Gly-Asp（RGD）、Ile-Lys-Val-Ala-Val（IKVAV）和Tyr-Ile-Gly-Ser-Arg（YIGSR），它们用于修饰这些多糖水凝胶，以增强细胞行为，包括存活、粘附、增殖和迁移。综述了它们在组织工程中的应用。

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SHORT PEPTIDE-BASED POLYSACCHARIDE HYDROGELS FOR TISSUE ENGINEERING: A MINI REVIEW

The usage of short peptide-based polysaccharide hydrogels for tissue engineering was discussed in this review. It explained the drawbacks of employing short peptide-based polysaccharide hydrogels as tissue regeneration scaffolds, while highlighting their benefits. In this review, we first gave a brief overview of short peptide-based polysaccharide hydrogel design process. Then, we provided additionally detailed information of the hydrogels with categorized polysaccharides (hyaluronic acid, dextran, chitosan, alginate, and agarose). We also explained the bioactive short peptides Arg-Gly-Asp (RGD), Ile-Lys-Val-Ala-Val (IKVAV), and Tyr-Ile-Gly-Ser-Arg (YIGSR) that were used to modify these polysaccharide hydrogels in order to enhance cell behaviors, including survival, adhesion, proliferation, and migration. Their applications in tissue engineering were also demonstrated and summarized in this review.

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来源期刊

Cellulose Chemistry and Technology 工程技术-材料科学：纸与木材

CiteScore

2.30

自引率

23.10%

发文量

审稿时长

7.3 months

期刊介绍： Cellulose Chemistry and Technology covers the study and exploitation of the industrial applications of carbohydrate polymers in areas such as food, textiles, paper, wood, adhesives, pharmaceuticals, oil field applications and industrial chemistry. Topics include: • studies of structure and properties • biological and industrial development • analytical methods • chemical and microbiological modifications • interactions with other materials