Carolina S. Ferreira , Gabriela D.A. Pinto , Desirée L. Reis , Claire Vigor , Vanessa A. Goes , Deborah de A.B. Guimarães , Daniela B. Mucci , Livia Belcastro , Marcelle A. Saraiva , Camille Oger , Jean-Marie Galano , Fátima L.C. Sardinha , Alexandre G. Torres , Thierry Durand , Graham J. Burton , Tatiana El-Bacha
{"title":"妊娠期糖尿病和母体肥胖患者胎盘F4神经前列腺素和F2异前列腺素的改变","authors":"Carolina S. Ferreira , Gabriela D.A. Pinto , Desirée L. Reis , Claire Vigor , Vanessa A. Goes , Deborah de A.B. Guimarães , Daniela B. Mucci , Livia Belcastro , Marcelle A. Saraiva , Camille Oger , Jean-Marie Galano , Fátima L.C. Sardinha , Alexandre G. Torres , Thierry Durand , Graham J. Burton , Tatiana El-Bacha","doi":"10.1016/j.plefa.2022.102529","DOIUrl":null,"url":null,"abstract":"<div><p>We investigated whether gestational diabetes mellitus (GDM) associated with maternal obesity modifies the placental profile of F<sub>4</sub>-Neuroprostanes and F<sub>2</sub>-Isoprostanes, metabolites of non-enzymatic oxidation of docosahexaenoic acid (DHA) and arachidonic acid (AA), respectively. Twenty-five placental samples were divided into lean (<em>n</em>=11), obesity (<em>n</em>=7) and overweight/obesity+GDM (<em>n</em>=7) groups. F<sub>4</sub>-Neuroprostanes and F<sub>2</sub>-Isoprostanes were higher in obesity compared to lean controls, but reduced to levels similar to lean women when obesity is further complicated with GDM. Lower content of F<sub>2</sub>-Isoprostanes suggests adaptive placental responses in GDM attenuating oxidative stress. However, low levels of placental F<sub>4</sub>-Neuroprostanes may indicate impaired DHA metabolism in GDM, affecting fetal development and offspring health. These results were not related to differences in placental content of DHA, AA and polyunsaturated fatty acids status nor to maternal diet or gestational weight gain. Placental DHA and AA metabolism differs in obesity and GDM, highlighting the importance of investigating the signalling roles of F<sub>4</sub>-Neuroprostanes and F<sub>2</sub>-Isoprostanes in the human term placenta.</p></div>","PeriodicalId":94179,"journal":{"name":"Prostaglandins, leukotrienes, and essential fatty acids","volume":null,"pages":null},"PeriodicalIF":3.0000,"publicationDate":"2023-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Placental F4-Neuroprostanes and F2-Isoprostanes are altered in gestational diabetes mellitus and maternal obesity\",\"authors\":\"Carolina S. Ferreira , Gabriela D.A. Pinto , Desirée L. Reis , Claire Vigor , Vanessa A. Goes , Deborah de A.B. Guimarães , Daniela B. Mucci , Livia Belcastro , Marcelle A. Saraiva , Camille Oger , Jean-Marie Galano , Fátima L.C. Sardinha , Alexandre G. Torres , Thierry Durand , Graham J. Burton , Tatiana El-Bacha\",\"doi\":\"10.1016/j.plefa.2022.102529\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>We investigated whether gestational diabetes mellitus (GDM) associated with maternal obesity modifies the placental profile of F<sub>4</sub>-Neuroprostanes and F<sub>2</sub>-Isoprostanes, metabolites of non-enzymatic oxidation of docosahexaenoic acid (DHA) and arachidonic acid (AA), respectively. Twenty-five placental samples were divided into lean (<em>n</em>=11), obesity (<em>n</em>=7) and overweight/obesity+GDM (<em>n</em>=7) groups. F<sub>4</sub>-Neuroprostanes and F<sub>2</sub>-Isoprostanes were higher in obesity compared to lean controls, but reduced to levels similar to lean women when obesity is further complicated with GDM. Lower content of F<sub>2</sub>-Isoprostanes suggests adaptive placental responses in GDM attenuating oxidative stress. However, low levels of placental F<sub>4</sub>-Neuroprostanes may indicate impaired DHA metabolism in GDM, affecting fetal development and offspring health. These results were not related to differences in placental content of DHA, AA and polyunsaturated fatty acids status nor to maternal diet or gestational weight gain. Placental DHA and AA metabolism differs in obesity and GDM, highlighting the importance of investigating the signalling roles of F<sub>4</sub>-Neuroprostanes and F<sub>2</sub>-Isoprostanes in the human term placenta.</p></div>\",\"PeriodicalId\":94179,\"journal\":{\"name\":\"Prostaglandins, leukotrienes, and essential fatty acids\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":3.0000,\"publicationDate\":\"2023-02-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Prostaglandins, leukotrienes, and essential fatty acids\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S0952327822001417\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Prostaglandins, leukotrienes, and essential fatty acids","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0952327822001417","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Placental F4-Neuroprostanes and F2-Isoprostanes are altered in gestational diabetes mellitus and maternal obesity
We investigated whether gestational diabetes mellitus (GDM) associated with maternal obesity modifies the placental profile of F4-Neuroprostanes and F2-Isoprostanes, metabolites of non-enzymatic oxidation of docosahexaenoic acid (DHA) and arachidonic acid (AA), respectively. Twenty-five placental samples were divided into lean (n=11), obesity (n=7) and overweight/obesity+GDM (n=7) groups. F4-Neuroprostanes and F2-Isoprostanes were higher in obesity compared to lean controls, but reduced to levels similar to lean women when obesity is further complicated with GDM. Lower content of F2-Isoprostanes suggests adaptive placental responses in GDM attenuating oxidative stress. However, low levels of placental F4-Neuroprostanes may indicate impaired DHA metabolism in GDM, affecting fetal development and offspring health. These results were not related to differences in placental content of DHA, AA and polyunsaturated fatty acids status nor to maternal diet or gestational weight gain. Placental DHA and AA metabolism differs in obesity and GDM, highlighting the importance of investigating the signalling roles of F4-Neuroprostanes and F2-Isoprostanes in the human term placenta.
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