妊娠期糖尿病和母体肥胖患者胎盘F4神经前列腺素和F2异前列腺素的改变

Carolina S. Ferreira , Gabriela D.A. Pinto , Desirée L. Reis , Claire Vigor , Vanessa A. Goes , Deborah de A.B. Guimarães , Daniela B. Mucci , Livia Belcastro , Marcelle A. Saraiva , Camille Oger , Jean-Marie Galano , Fátima L.C. Sardinha , Alexandre G. Torres , Thierry Durand , Graham J. Burton , Tatiana El-Bacha
{"title":"妊娠期糖尿病和母体肥胖患者胎盘F4神经前列腺素和F2异前列腺素的改变","authors":"Carolina S. Ferreira ,&nbsp;Gabriela D.A. Pinto ,&nbsp;Desirée L. Reis ,&nbsp;Claire Vigor ,&nbsp;Vanessa A. Goes ,&nbsp;Deborah de A.B. Guimarães ,&nbsp;Daniela B. Mucci ,&nbsp;Livia Belcastro ,&nbsp;Marcelle A. Saraiva ,&nbsp;Camille Oger ,&nbsp;Jean-Marie Galano ,&nbsp;Fátima L.C. Sardinha ,&nbsp;Alexandre G. Torres ,&nbsp;Thierry Durand ,&nbsp;Graham J. Burton ,&nbsp;Tatiana El-Bacha","doi":"10.1016/j.plefa.2022.102529","DOIUrl":null,"url":null,"abstract":"<div><p>We investigated whether gestational diabetes mellitus (GDM) associated with maternal obesity modifies the placental profile of F<sub>4</sub>-Neuroprostanes and F<sub>2</sub>-Isoprostanes, metabolites of non-enzymatic oxidation of docosahexaenoic acid (DHA) and arachidonic acid (AA), respectively. Twenty-five placental samples were divided into lean (<em>n</em>=11), obesity (<em>n</em>=7) and overweight/obesity+GDM (<em>n</em>=7) groups. F<sub>4</sub>-Neuroprostanes and F<sub>2</sub>-Isoprostanes were higher in obesity compared to lean controls, but reduced to levels similar to lean women when obesity is further complicated with GDM. Lower content of F<sub>2</sub>-Isoprostanes suggests adaptive placental responses in GDM attenuating oxidative stress. However, low levels of placental F<sub>4</sub>-Neuroprostanes may indicate impaired DHA metabolism in GDM, affecting fetal development and offspring health. These results were not related to differences in placental content of DHA, AA and polyunsaturated fatty acids status nor to maternal diet or gestational weight gain. Placental DHA and AA metabolism differs in obesity and GDM, highlighting the importance of investigating the signalling roles of F<sub>4</sub>-Neuroprostanes and F<sub>2</sub>-Isoprostanes in the human term placenta.</p></div>","PeriodicalId":94179,"journal":{"name":"Prostaglandins, leukotrienes, and essential fatty acids","volume":"189 ","pages":"Article 102529"},"PeriodicalIF":3.0000,"publicationDate":"2023-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Placental F4-Neuroprostanes and F2-Isoprostanes are altered in gestational diabetes mellitus and maternal obesity\",\"authors\":\"Carolina S. Ferreira ,&nbsp;Gabriela D.A. Pinto ,&nbsp;Desirée L. Reis ,&nbsp;Claire Vigor ,&nbsp;Vanessa A. Goes ,&nbsp;Deborah de A.B. Guimarães ,&nbsp;Daniela B. Mucci ,&nbsp;Livia Belcastro ,&nbsp;Marcelle A. Saraiva ,&nbsp;Camille Oger ,&nbsp;Jean-Marie Galano ,&nbsp;Fátima L.C. Sardinha ,&nbsp;Alexandre G. Torres ,&nbsp;Thierry Durand ,&nbsp;Graham J. Burton ,&nbsp;Tatiana El-Bacha\",\"doi\":\"10.1016/j.plefa.2022.102529\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>We investigated whether gestational diabetes mellitus (GDM) associated with maternal obesity modifies the placental profile of F<sub>4</sub>-Neuroprostanes and F<sub>2</sub>-Isoprostanes, metabolites of non-enzymatic oxidation of docosahexaenoic acid (DHA) and arachidonic acid (AA), respectively. Twenty-five placental samples were divided into lean (<em>n</em>=11), obesity (<em>n</em>=7) and overweight/obesity+GDM (<em>n</em>=7) groups. F<sub>4</sub>-Neuroprostanes and F<sub>2</sub>-Isoprostanes were higher in obesity compared to lean controls, but reduced to levels similar to lean women when obesity is further complicated with GDM. Lower content of F<sub>2</sub>-Isoprostanes suggests adaptive placental responses in GDM attenuating oxidative stress. However, low levels of placental F<sub>4</sub>-Neuroprostanes may indicate impaired DHA metabolism in GDM, affecting fetal development and offspring health. These results were not related to differences in placental content of DHA, AA and polyunsaturated fatty acids status nor to maternal diet or gestational weight gain. Placental DHA and AA metabolism differs in obesity and GDM, highlighting the importance of investigating the signalling roles of F<sub>4</sub>-Neuroprostanes and F<sub>2</sub>-Isoprostanes in the human term placenta.</p></div>\",\"PeriodicalId\":94179,\"journal\":{\"name\":\"Prostaglandins, leukotrienes, and essential fatty acids\",\"volume\":\"189 \",\"pages\":\"Article 102529\"},\"PeriodicalIF\":3.0000,\"publicationDate\":\"2023-02-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Prostaglandins, leukotrienes, and essential fatty acids\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S0952327822001417\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Prostaglandins, leukotrienes, and essential fatty acids","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0952327822001417","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0

摘要

我们研究了与母体肥胖相关的妊娠期糖尿病(GDM)是否会改变F4神经前列腺素和F2异前列腺素的胎盘特征,这两种物质分别是二十二碳六烯酸(DHA)和花生四烯酸(AA)的非酶氧化代谢产物。25份胎盘样本被分为瘦组(n=11)、肥胖组(n=7)和超重/肥胖+GDM组(n=8)。与瘦对照组相比,肥胖组的F4神经前列素和F2异前列素含量较高,但当肥胖与GDM进一步复杂时,其含量降至与瘦女性相似的水平。F2异前列素含量较低表明GDM中的适应性胎盘反应减弱了氧化应激。然而,胎盘F4神经前列素水平低可能表明GDM中DHA代谢受损,影响胎儿发育和后代健康。这些结果与胎盘DHA、AA和多不饱和脂肪酸含量的差异无关,也与母体饮食或妊娠期体重增加无关。肥胖和GDM的胎盘DHA和AA代谢不同,这突出了研究F4神经前列腺素和F2异前列腺素在人类足月胎盘中的信号作用的重要性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
Placental F4-Neuroprostanes and F2-Isoprostanes are altered in gestational diabetes mellitus and maternal obesity

We investigated whether gestational diabetes mellitus (GDM) associated with maternal obesity modifies the placental profile of F4-Neuroprostanes and F2-Isoprostanes, metabolites of non-enzymatic oxidation of docosahexaenoic acid (DHA) and arachidonic acid (AA), respectively. Twenty-five placental samples were divided into lean (n=11), obesity (n=7) and overweight/obesity+GDM (n=7) groups. F4-Neuroprostanes and F2-Isoprostanes were higher in obesity compared to lean controls, but reduced to levels similar to lean women when obesity is further complicated with GDM. Lower content of F2-Isoprostanes suggests adaptive placental responses in GDM attenuating oxidative stress. However, low levels of placental F4-Neuroprostanes may indicate impaired DHA metabolism in GDM, affecting fetal development and offspring health. These results were not related to differences in placental content of DHA, AA and polyunsaturated fatty acids status nor to maternal diet or gestational weight gain. Placental DHA and AA metabolism differs in obesity and GDM, highlighting the importance of investigating the signalling roles of F4-Neuroprostanes and F2-Isoprostanes in the human term placenta.

求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
Prostaglandins, leukotrienes, and essential fatty acids
Prostaglandins, leukotrienes, and essential fatty acids Clinical Biochemistry, Endocrinology, Diabetes and Metabolism
CiteScore
5.30
自引率
0.00%
发文量
0
审稿时长
64 days
期刊最新文献
Gallein but not fluorescein enhances the PGD2-stimulated synthesis of osteoprotegerin and interleukin-6 in osteoblasts Omega-3 fatty acids mitigate skin damage caused by ultraviolet-B radiation The disparate effects of omega-3 PUFAs on intestinal microbial homeostasis in experimental rodents under physiological condition Resolvin D4 mitigates lipopolysaccharide-induced lung injury in mice Blood EPA and DHA status among people living in the United States from 2000 to 2023
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1