异种分枝杆菌阳性的六种呼吸道培养物集群——临床特征和基因组特征

Kendall Kling , Rebecca Osborn , Adil Menon , Janna Williams , Ryan Cardew , Omar Al-Heeti , Phillip Santoiemma , Michael Angarone , Samuel Gatesy , Travis Kochan , Teresa Zembower , Karen Krueger , Egon A. Ozer , Chao Qi
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引用次数: 0

摘要

异种分枝杆菌是一种从水系统中分离出来的生长缓慢的非结核分枝杆菌(NTM),与人类的假暴发和肺部感染有关。在我们机构的六个月内,我们观察到六种呼吸道培养物呈异种隐球菌阳性,大约是我们正常分离率的两倍。六个病例中只有三个符合NTM感染的临床、放射学和微生物学标准。我们医院的医疗流行病学和感染项目领导的一项调查发现,这六名患者之间没有流行病学联系。三个分离株进行了全基因组测序和系统发育分析,证实它们是非克隆的。体外药敏数据发现,分离株对大环内酯类、莫西沙星和利福布丁敏感。我们的研究结果表明,从肺部标本中分离到的异种隐球菌可能正在增加,进一步定义了这种潜在新发感染的基因组群体结构,并将WGS确立为疫情调查菌株分型的有用工具。
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A cluster of six respiratory cultures positive for Mycobacterium xenopi –Clinical characteristics and genomic characterization

Mycobacterium xenopi is a slow growing non-tuberculous mycobacterium (NTM) isolated from water systems and has been associated with pseudo-outbreaks and pulmonary infections in humans. We observed a cluster of six respiratory cultures positive for M. xenopi within a six-month period at our institution, approximately double our normal isolation rate of this organism. Only three of the six cases met clinical, radiographic, and microbiologic criteria for NTM infection. An investigation led by our hospital’s Healthcare Epidemiology and Infection Program found no epidemiologic link between the six patients. Three isolates underwent whole-genome sequencing (WGS) and phylogenetic analysis confirmed they were non-clonal. In vitro susceptibility data found the isolates were sensitive to macrolides, moxifloxacin, and rifabutin. Our findings suggest that isolation of M. xenopi from pulmonary specimens may be increasing, further defines the genomic population structure of this potentially emerging infection, and establishes WGS as a useful tool for outbreak investigation strain typing.

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来源期刊
Journal of Clinical Tuberculosis and Other Mycobacterial Diseases
Journal of Clinical Tuberculosis and Other Mycobacterial Diseases Medicine-Pulmonary and Respiratory Medicine
CiteScore
4.00
自引率
5.00%
发文量
44
审稿时长
30 weeks
期刊介绍: Journal of Clinical Tuberculosis and Mycobacterial Diseases aims to provide a forum for clinically relevant articles on all aspects of tuberculosis and other mycobacterial infections, including (but not limited to) epidemiology, clinical investigation, transmission, diagnosis, treatment, drug-resistance and public policy, and encourages the submission of clinical studies, thematic reviews and case reports. Journal of Clinical Tuberculosis and Mycobacterial Diseases is an Open Access publication.
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