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Endogenous reactivation cases identified by whole genome sequencing of Mycobacterium tuberculosis: Exploration of possible causes in Latvian tuberculosis patients 通过结核分枝杆菌全基因组测序发现的内源性再活化病例:拉脱维亚结核病患者中可能存在的病因探究
IF 1.9 Q3 INFECTIOUS DISEASES Pub Date : 2024-10-31 DOI: 10.1016/j.jctube.2024.100493

Background

The recurrence of tuberculosis (TB) continues to place a significant burden on patients and TB programs worldwide. Repeated TB episodes can develop either due to endogenous reactivation of previously treated TB or exogenous reinfection with a distinct strain of Mycobacterium tuberculosis (Mtb). Determining the precise cause of the recurrent TB episodes and identifying reasons for endogenous reactivation of previously successfully treated patients is crucial for introducing effective TB control measures.

Methods

Here, we aimed to provide a retrospective individual analysis of the clinical data of pulmonary TB patients with assumed endogenous infection reactivation based on WGS results to identify the reasons for reactivation. Patient medical files were reviewed to describe the provoking factors for endogenous reactivation.

Results

In total, 25 patients with assumed endogenous TB reactivation were included in the study group, and 30 patients with one TB episode during the study period were included in the control group. There were no statistically significant differences identified between studied patient groups in patients age (t(53) = −1.53, p = 0.13), body mass index (t(53) = 0.82, p = 0.42), area of residency (χ2(1;55) = 0.015, p = 0.9), employment status (χ2(1;55) = 0.076, p = 0.78) and presence of comorbidities (χ2(1;55) = 3.67, p = 0.78). Study group patients had statistically significantly more frequently positive sputum smear microscopy results (χ2(1;55) = 8.72, p = 0.0031), longer time to sputum smear (t(31) = −2.2, p = 0.036) and sputum culture conversion (W (55) = 198.5, p = 0.0029). Smoking was statistically significantly (χ2(1;55) = 5.77, p = 0.016) more frequently represented among study group patients. The median treatment duration for drug susceptible TB was 6 months in both in the control group (IQR 6–6) and among study group patients (IQR 6–7.75). The median treatment duration for multidrug-resistant TB was 20 months (IQR 17–23) in the control group and 19 months (IQR 16–19) in the study group patients.

Conclusion

Positive SSM for acid-fast bacteria, delayed time to sputum smear and sputum culture conversion, smoking, and incomplete therapy in the study group patients with multidrug-resistant TB should be considered as potential reasons for reactivation in recurrent TB patient group in our study.
背景结核病(TB)的复发继续给全球患者和结核病防治项目带来沉重负担。结核病反复发作的原因可能是以前治疗过的结核病内源性再激活,也可能是结核分枝杆菌(Mtb)的外源性再感染。确定结核病反复发作的确切原因,并找出先前成功治疗过的患者内源性再激活的原因,对于采取有效的结核病控制措施至关重要。方法在此,我们旨在根据 WGS 结果对假定内源性感染再激活的肺结核患者的临床数据进行回顾性个体分析,以找出再激活的原因。结果 研究组共纳入 25 名假定内源性肺结核再激活患者,对照组共纳入 30 名在研究期间有过一次肺结核发作的患者。研究组患者在年龄(t(53) = -1.53, p = 0.13)、体重指数(t(53) = 0.82,p = 0.42)、居住地区(χ2(1;55)= 0.015,p = 0.9)、就业状况(χ2(1;55)= 0.076,p = 0.78)和是否存在合并症(χ2(1;55)= 3.67,p = 0.78)。研究组患者痰涂片镜检结果呈阳性的频率明显更高(χ2(1;55)=8.72,P=0.0031),痰涂片时间更长(t(31)=-2.2,P=0.036),痰培养转阴率明显更高(W(55)=198.5,P=0.0029)。研究组患者中吸烟人数明显增多(χ2(1;55) = 5.77,p = 0.016)。对照组(IQR 6-6)和研究组患者(IQR 6-7.75)对药物敏感肺结核的中位治疗时间均为 6 个月。结论在我们的研究中,研究组耐多药肺结核患者的酸性耐药菌 SSM 阳性、痰涂片和痰培养转阴时间延迟、吸烟和治疗不彻底应被视为复发性肺结核患者再次活化的潜在原因。
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引用次数: 0
Bovine tuberculosis reactor cattle in Southwest Ethiopia: Risk factors for bovine tuberculosis 埃塞俄比亚西南部的牛结核病反应牛:牛结核病的风险因素
IF 1.9 Q3 INFECTIOUS DISEASES Pub Date : 2024-10-29 DOI: 10.1016/j.jctube.2024.100492
Bovine tuberculosis, caused by Mycobacterium bovis, is a chronic zoonotic disease that persists in Ethiopia despite global control efforts, impacting public health and the economy. However, little is known about the epidemiology of bovine tuberculosis in Southwest Ethiopia. This study aims to assess the prevalence of bovine tuberculosis and identify associated risk factors in dairy cattle. A cross-sectional study was conducted from October 2022 to October 2023 in four districts in the Sheka, Bench-Sheko, and Keffa zones. A multistage sampling approach was employed, resulting in the selection of 1,152 cattle from various herds. Tuberculin skin testing was performed to detect bovine tuberculosis, and data on potential risk factors were collected through questionnaires. Logistic regression models were used to analyze the association between bovine tuberculosis and various risk factors. The overall prevalence of bovine tuberculosis was 4.95% at the cow level and 22.19% at the herd level in the study areas. Significant herd-level risk factors for bovine tuberculosis included lowland areas, larger herd sizes, and the introducing new animals. At the cow level, risk factors included age, breed, body condition, herd size, introduction of new animals, and management system. The study reveals a high prevalence of bovine tuberculosis in dairy cattle in Southwest Ethiopia, identifying key risk factors. Effective control requires targeted interventions, such as improved management practices, enhanced farmer awareness, and a better understanding of and guidance on bovine tuberculosis strategies in Ethiopia. Future research should isolate and characterize M. bovis in the study areas.
由牛分枝杆菌引起的牛结核病是一种慢性人畜共患病,尽管全球都在努力控制,但这种疾病在埃塞俄比亚依然存在,对公共卫生和经济造成了影响。然而,人们对埃塞俄比亚西南部牛结核病的流行病学知之甚少。本研究旨在评估奶牛结核病的流行情况,并确定相关的风险因素。研究于 2022 年 10 月至 2023 年 10 月在 Sheka、Bench-Sheko 和 Keffa 区的四个县进行了横断面研究。研究采用了多阶段抽样方法,从不同牛群中选取了 1,152 头牛。通过结核菌素皮试检测牛结核病,并通过问卷调查收集潜在风险因素的数据。采用逻辑回归模型分析牛结核病与各种风险因素之间的关联。在研究地区,牛结核病的总体发病率在奶牛层面为 4.95%,在牛群层面为 22.19%。牛结核病在牛群层面的重要风险因素包括低洼地区、牛群规模较大以及引进新牲畜。在奶牛层面,风险因素包括年龄、品种、体况、牛群规模、引进新牲畜和管理制度。这项研究揭示了埃塞俄比亚西南部奶牛中牛结核病的高流行率,并确定了关键的风险因素。有效的控制需要有针对性的干预措施,如改进管理方法、提高农民意识、更好地了解和指导埃塞俄比亚的牛结核病防治策略。未来的研究应分离研究地区的牛结核杆菌并确定其特征。
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引用次数: 0
Rapidly growing knowledge of Mycobacterium smegmatis: A case series and review of antimicrobial susceptibility patterns 迅速增长的烟肉分枝杆菌知识:病例系列和抗菌药敏感性模式综述
IF 1.9 Q3 INFECTIOUS DISEASES Pub Date : 2024-10-22 DOI: 10.1016/j.jctube.2024.100489
Mycobacterium smegmatis is a rapidly growing nontuberculous mycobacterium that is rarely isolated from clinical specimens and is frequently considered to be a contaminant. We conducted a retrospective review of mycobacterial cultures positive for M. smegmatis from 1998 to 2023 at our institution to evaluate the clinical significance of recovering this mycobacterium. Antimicrobial susceptibility patterns were also determined. Twenty-two M. smegmatis isolates were identified from 17 patients, 12 of whom met criteria for clinical chart review. M. smegmatis was deemed a cause of infection in 5/5 isolates from skin or soft tissue, 3/3 from bone, 1/1 from blood, and 0/3 from respiratory specimens. All cases thought to be significant were treated with at least 2 active agents for periods varying from 2 weeks up to 8 months. 18 isolates had antimicrobial susceptibility testing performed and all were susceptible to doxycycline, imipenem, linezolid, moxifloxacin, trimethoprim/sulfamethoxazole, and tobramycin while all isolates were resistant to clarithromycin. When recovered in culture, the presence of M. smegmatis should be correlated with clinical presentation as it may represent a true infection.
烟肉分枝杆菌是一种生长迅速的非结核分枝杆菌,很少从临床标本中分离出来,通常被认为是一种污染物。我们对本机构 1998 年至 2023 年间培养出的烟肉分枝杆菌阳性分枝杆菌进行了回顾性研究,以评估回收这种分枝杆菌的临床意义。同时还确定了抗菌药敏感性模式。从 17 名患者中鉴定出 22 个烟曲霉分离株,其中 12 人符合临床病历审查标准。从皮肤或软组织分离到的 5/5 株、从骨骼分离到的 3/3 株、从血液分离到的 1/1 株、从呼吸道标本分离到的 0/3 株中,有 5/5 株被认为是感染的原因。所有被认为有重大意义的病例都接受了至少 2 种活性药物的治疗,治疗时间从 2 周到 8 个月不等。对 18 个分离株进行了抗菌药敏感性检测,所有分离株都对多西环素、亚胺培南、利奈唑胺、莫西沙星、三甲双胍/磺胺甲噁唑和妥布霉素敏感,而所有分离株都对克拉霉素耐药。当培养物中回收到烟曲霉菌时,应将其与临床表现联系起来,因为它可能代表真正的感染。
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引用次数: 0
A predictive score for early in-patient tuberculosis mortality: A case-control study 早期肺结核住院病人死亡率预测评分:病例对照研究
IF 1.9 Q3 INFECTIOUS DISEASES Pub Date : 2024-10-21 DOI: 10.1016/j.jctube.2024.100487

Introduction

In-hospital mortality rates for tuberculosis (TB) patients are high within the first seven days of admission. This study sought to identify predictors of early inpatient mortality and assess the performance of a predictive score for early mortality in a Ugandan tertiary hospital.

Materials and methods

A case-control study was conducted at Kiruddu National Referral Hospital in Kampala, Uganda. Cases included patients admitted with TB who died within seven days of admission, while controls survived beyond this period. Logistic regression was utilized to identify early mortality predictors. The performance of an adapted predictive score (PROS score) was evaluated, assigning scores based on the following criteria: Pulse rate >100 beats/min (1 point), Respiratory rate >20 breaths/min (2 points), Oxygen saturation <92 % (4 points), and Systolic blood pressure <90 mmHg (2 points).

Results

Of 602 hospitalized TB patients, 187 (31.0 %) died during admission. Among these, 78 (41.7 %) died within seven days. Wasting (adjusted odds ratio [aOR] = 5.76, 95 % confidence interval [CI] 2.12–15.63, p = 0.001) and respiratory rate >20 breaths/min (aOR = 2.89, 95 % CI 1.19–7.00, p = 0.019) predicted early mortality. PROS score of ≥1 demonstrated a sensitivity of 87.8 % and negative predictive value of 90.0 %. The ultimate TB treatment success rate of all hospitalized patients (n = 599) was 47.4 % with 275 (45.9 %) dying during TB treatment.

Conclusion

Early and long term mortality rates among hospitalized TB patients are high. Wasting and tachypnea predict early inpatient mortality. The PROS score could be useful in ruling out low-risk patients in low-resource settings.
引言 结核病(TB)患者在入院头七天内的院内死亡率很高。这项研究旨在确定早期住院病人死亡率的预测因素,并评估乌干达一家三级医院早期死亡率预测评分的性能。材料与方法 在乌干达坎帕拉的基鲁杜国家转诊医院进行了一项病例对照研究。病例包括入院后七天内死亡的肺结核患者,而对照组患者在入院七天后仍存活。采用逻辑回归法确定早期死亡率预测因素。评估了经调整的预测评分(PROS 评分)的性能,评分标准如下:结果 在 602 名住院肺结核患者中,187 人(31.0%)在入院期间死亡。其中 78 人(41.7%)在七天内死亡。消瘦(调整赔率 [aOR] = 5.76,95 % 置信区间 [CI] 2.12-15.63,p = 0.001)和呼吸频率为 20 次/分(aOR = 2.89,95 % CI 1.19-7.00,p = 0.019)预示着早期死亡。PROS 评分≥1 的灵敏度为 87.8%,阴性预测值为 90.0%。所有住院患者(599 人)的最终结核病治疗成功率为 47.4%,其中 275 人(45.9%)在结核病治疗期间死亡。虚脱和呼吸急促可预测住院病人的早期死亡率。PROS 评分有助于排除低资源环境中的低风险患者。
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引用次数: 0
Diagnostic value of tuberculosis-Specific antigens Ag85B, ESAT-6 and CFP10 in pulmonary tuberculosis 肺结核特异抗原 Ag85B、ESAT-6 和 CFP10 在肺结核中的诊断价值
IF 1.9 Q3 INFECTIOUS DISEASES Pub Date : 2024-10-19 DOI: 10.1016/j.jctube.2024.100486

Objectives

To assess the diagnostic value of tuberculosis-secreted Ag85B, ESAT-6 and CFP10 in pulmonary tuberculosis.

Method

Immunohistochemical (IHC) and acid-fast staining were performed, the detection efficiency of the two methods were analysed with chi-square test.

Results

Acid-fast staining demonstrated a sensitivity of (18/69, 26.09%) and a specificity of 100%. IHC staining for Ag85B, ESAT-6 and CFP10 was positive in all 18 cases with positive acid-fast staining and additionally positive in 25,36 and 30 cases, respectively, that were acid-fast-negative. The sensitivities of IHC staining for Ag85B, ESAT-6 and CFP10 were 62.32%, 78.26% and69.57%, respectively, while their specificities were 86.57%, 85.07% and 91.04%, respectively. Joint antigen analysis revealed that simultaneous positivity for two or three of Ag85B, ESAT-6 and CFP10 increased specificity (95.52% to 100%) but decreased sensitivity (49.28% to 62.31%). The presence of any one of the three antigens elevated sensitivity (81.16% to 88.41%) but lowered specificity (68.66% to 77.61%). Specificity reached 100% for concurrent positivity of all three antigens, while a sensitivity of 88.41% was observed for positivity of any one antigen.

Conclusions

Ag85B, ESAT-6, and CFP10 exhibits greater sensitivity in pulmonary tuberculosis and combined antigen testing enhances the diagnostic accuracy.
目的 评估肺结核分泌的 Ag85B、ESAT-6 和 CFP10 的诊断价值。方法 进行免疫组织化学(IHC)染色和耐酸染色,并用卡方检验分析两种方法的检测效率。结果 耐酸染色的灵敏度为(18/69,26.09%),特异性为 100%。在所有 18 例酸性-快速染色阳性病例中,Ag85B、ESAT-6 和 CFP10 的 IHC 染色结果均为阳性;在 25、36 和 30 例酸性-快速染色阴性病例中,Ag85B、ESAT-6 和 CFP10 的 IHC 染色结果也分别为阳性。IHC染色对Ag85B、ESAT-6和CFP10的敏感性分别为62.32%、78.26%和69.57%,特异性分别为86.57%、85.07%和91.04%。联合抗原分析表明,Ag85B、ESAT-6 和 CFP10 中的两种或三种同时阳性会增加特异性(95.52% 至 100%),但会降低敏感性(49.28% 至 62.31%)。三种抗原中任何一种抗原的存在都会提高敏感性(81.16% 至 88.41%),但会降低特异性(68.66% 至 77.61%)。结论Ag85B、ESAT-6 和 CFP10 对肺结核具有更高的敏感性,联合抗原检测可提高诊断的准确性。
{"title":"Diagnostic value of tuberculosis-Specific antigens Ag85B, ESAT-6 and CFP10 in pulmonary tuberculosis","authors":"","doi":"10.1016/j.jctube.2024.100486","DOIUrl":"10.1016/j.jctube.2024.100486","url":null,"abstract":"<div><h3>Objectives</h3><div>To assess the diagnostic value of tuberculosis-secreted Ag85B, ESAT-6 and CFP10 in pulmonary tuberculosis.</div></div><div><h3>Method</h3><div>Immunohistochemical (IHC) and acid-fast staining were performed, the detection efficiency of the two methods were analysed with chi-square test.</div></div><div><h3>Results</h3><div>Acid-fast staining demonstrated a sensitivity of (18/69, 26.09%) and a specificity of 100%. IHC staining for Ag85B, ESAT-6 and CFP10 was positive in all 18 cases with positive acid-fast staining and additionally positive in 25,36 and 30 cases, respectively, that were acid-fast-negative. The sensitivities of IHC staining for Ag85B, ESAT-6 and CFP10 were 62.32%, 78.26% and69.57%, respectively, while their specificities were 86.57%, 85.07% and 91.04%, respectively. Joint antigen analysis revealed that simultaneous positivity for two or three of Ag85B, ESAT-6 and CFP10 increased specificity (95.52% to 100%) but decreased sensitivity (49.28% to 62.31%). The presence of any one of the three antigens elevated sensitivity (81.16% to 88.41%) but lowered specificity (68.66% to 77.61%). Specificity reached 100% for concurrent positivity of all three antigens, while a sensitivity of 88.41% was observed for positivity of any one antigen.</div></div><div><h3>Conclusions</h3><div>Ag85B, ESAT-6, and CFP10 exhibits greater sensitivity in pulmonary tuberculosis and combined antigen testing enhances the diagnostic accuracy.</div></div>","PeriodicalId":37942,"journal":{"name":"Journal of Clinical Tuberculosis and Other Mycobacterial Diseases","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2024-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142528134","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Variants in the N-acetyltranferase 2 gene, acetylator phenotypes and their association with tuberculosis: Findings in Peruvian patients N-acetyltranferase 2 基因变异、乙酰化酶表型及其与结核病的关系:秘鲁患者的研究结果
IF 1.9 Q3 INFECTIOUS DISEASES Pub Date : 2024-10-16 DOI: 10.1016/j.jctube.2024.100485

Background

Tuberculosis (TB) is a highly prevalent chronic infectious disease in developing countries, with Peru being one of the most affected countries in the world. The variants of the N-acetyltransferase 2 (NAT2) gene are related to xenobiotic metabolism and have potential usefulness in TB studies.

Aim

To determine whether NAT2 gene variants and acetylator phenotypes are associated with active TB in Peruvian patients.

Methods

This study included cases (patients with TB) and controls (population-based data). First, DNA isolation and the rs1799929, rs1799930, and rs1799931 variants of the NAT2 gene were identified using sequencing methods. Subsequently, the acetylator phenotypes, namely slow (SA), intermediate (IA), and rapid acetylation (RA), were also analyzed.

Results

The comparison of the frequencies of the rs1799931 variant in the cases and controls revealed significant differences. Risk factors were found for both the A allele (p = 0.00; odds ratio [OR] = 3.04, 95 % confidence interval [CI]: 1.88–4.9) and AG genotype (p = 0.00; OR = 5.94, 95 % CI: 3.17–11.09). In addition, the non-rapid acetylator phenotype (SA + IA) was also found to be a risk factor (p = 0.016; OR = 3.16, 95 % CI: 1.29–7.72).

Conclusion

The A allele, GA heterozygous genotype of the rs1799931 variant of the NAT2 gene, and SA + IA acetylator phenotype showed an association with increased risk for the development of TB. In addition to xenobiotic metabolism, other metabolic and immunological functions of NAT2 have also been postulated to confer susceptibility to TB in the Peruvian population owing to its characteristic high Native American component.
背景结核病(TB)是发展中国家高发的慢性传染病,秘鲁是世界上受影响最严重的国家之一。N-acetyltransferase 2(NAT2)基因变异与异生物代谢有关,在结核病研究中具有潜在用途。首先,采用测序方法分离 DNA 并确定 NAT2 基因的 rs1799929、rs1799930 和 rs1799931 变体。随后,还分析了乙酰化表型,即缓慢乙酰化(SA)、中间乙酰化(IA)和快速乙酰化(RA)。发现 A 等位基因(p = 0.00;几率比 [OR] = 3.04,95 % 置信区间 [CI]:1.88-4.9)和 AG 基因型(p = 0.00;OR = 5.94,95 % 置信区间 [CI]:3.17-11.09)都是风险因素。结论 NAT2 基因 rs1799931 变体的 A 等位基因、GA 杂合子基因型和 SA + IA 乙酰化表型与结核病发病风险增加有关。在秘鲁人口中,除了异生物代谢外,NAT2 的其他代谢和免疫功能也被推测为导致结核病易感性的原因,因为秘鲁人口中美国土著成分较高。
{"title":"Variants in the N-acetyltranferase 2 gene, acetylator phenotypes and their association with tuberculosis: Findings in Peruvian patients","authors":"","doi":"10.1016/j.jctube.2024.100485","DOIUrl":"10.1016/j.jctube.2024.100485","url":null,"abstract":"<div><h3>Background</h3><div>Tuberculosis (TB) is a highly prevalent chronic infectious disease in developing countries, with Peru being one of the most affected countries in the world. The variants of the <em>N</em>-acetyltransferase 2 (<em>NAT2</em>) gene are related to xenobiotic metabolism and have potential usefulness in TB studies.</div></div><div><h3>Aim</h3><div>To determine whether <em>NAT2</em> gene variants and acetylator phenotypes are associated with active TB in Peruvian patients.</div></div><div><h3>Methods</h3><div>This study included cases (patients with TB) and controls (population-based data). First, DNA isolation and the rs1799929, rs1799930, and rs1799931 variants of the <em>NAT2</em> gene were identified using sequencing methods. Subsequently, the acetylator phenotypes, namely slow (SA), intermediate (IA), and rapid acetylation (RA), were also analyzed.</div></div><div><h3>Results</h3><div>The comparison of the frequencies of the rs1799931 variant in the cases and controls revealed significant differences. Risk factors were found for both the A allele (p = 0.00; odds ratio [OR] = 3.04, 95 % confidence interval [CI]: 1.88–4.9) and AG genotype (p = 0.00; OR = 5.94, 95 % CI: 3.17–11.09). In addition, the non-rapid acetylator phenotype (SA + IA) was also found to be a risk factor (p = 0.016; OR = 3.16, 95 % CI: 1.29–7.72).</div></div><div><h3>Conclusion</h3><div>The A allele, GA heterozygous genotype of the rs1799931 variant of the NAT2 gene, and SA + IA acetylator phenotype showed an association with increased risk for the development of TB. In addition to xenobiotic metabolism, other metabolic and immunological functions of <em>NAT2</em> have also been postulated to confer susceptibility to TB in the Peruvian population owing to its characteristic high Native American component.</div></div>","PeriodicalId":37942,"journal":{"name":"Journal of Clinical Tuberculosis and Other Mycobacterial Diseases","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2024-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142528131","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Mycobacterium tuberculosis evolution from monoresistance to pre-extensive drug resistance during a prolonged household outbreak 在一次长期家庭疫情中,结核分枝杆菌从单一抗药性进化到前期广泛抗药性
IF 1.9 Q3 INFECTIOUS DISEASES Pub Date : 2024-10-14 DOI: 10.1016/j.jctube.2024.100482
Whole genome sequencing (WGS) is sensitive tool for the analysis of tuberculosis transmission and drug-resistance. We used WGS to analyze the Mycobacterium tuberculosis evolution from isoniazid monoresistance to MDR/preXDR during a prolonged household outbreak. The outbreak started with a isoniazid resistant strain (katG S315T mutation) and evolve in two cases to pre-XDR phenotype (with mutations in katG, rpoB, embB, pncA and gyrA genes). Based on WGS data and epidemiological interview we proposed a possible chain of transmission an evolution of the strains.
Similar intra-patient and inter-patient acquisition of variability was observed, making difficult to distinguish reinfection or reactivation. Analysis of WGS data together with epidemiological clinical history are discussed in order to distinguish between prolonged infections or transition from latency to reactivation. Classical interview and clinical history taking should be consider to fully understanding WGS data. With a still low incidence of TB cases, Uruguay could use universal WGS of all isolates to reduce time of diagnosis, detect outbreaks and perform public actions to reduce TB incidence.
全基因组测序(WGS)是分析结核病传播和耐药性的灵敏工具。我们利用 WGS 分析了在一次长期家庭疫情中结核分枝杆菌从异烟肼单耐药到 MDR/preXDR 的演变过程。疫情始于耐异烟肼菌株(katG S315T 突变),并在两个病例中演变为前 XDR 表型(katG、rpoB、embB、pncA 和 gyrA 基因突变)。根据 WGS 数据和流行病学访谈,我们提出了菌株可能的传播链和演变过程。我们对 WGS 数据分析和流行病学临床病史进行了讨论,以区分是长期感染还是从潜伏期过渡到再激活。要充分理解 WGS 数据,应考虑传统的访谈和临床病史采集。在结核病发病率仍然较低的情况下,乌拉圭可以利用对所有分离菌株进行普遍的 WGS 检测来缩短诊断时间、发现疫情爆发并采取公共行动降低结核病发病率。
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引用次数: 0
Treatment outcomes among patients with isoniazid mono-resistant tuberculosis in Mumbai, India: A retrospective cohort study 印度孟买单耐药异烟肼结核病患者的治疗结果:回顾性队列研究
IF 1.9 Q3 INFECTIOUS DISEASES Pub Date : 2024-10-12 DOI: 10.1016/j.jctube.2024.100481

Background

Tuberculosis (TB) remains a significant cause of mortality globally, with India accounting for 27% of the estimated number of people with TB. Multidrug-resistant TB (MDR-TB) and isoniazid (INH) resistance pose additional challenges to effective treatment. We aimed to describe treatment outcomes of INH mono-resistant TB patients under programmatic conditions in Mumbai, India.

Methods

This retrospective cohort study was conducted at Shatabdi Hospital in Mumbai between 2019–2021.We described the clinical and demographic characteristics, treatment outcomes, and risk factors for unfavourable outcomes among patients with INH mono-resistant TB treated with rifampicin, ethambutol, pyrazinamide, and levofloxacin (LfxREZ) for a duration of 6 months.

Results

Among 3105 patients with drug-resistant TB initiated on treatment, 217 (7 %) had INH mono-resistant TB. Of these, 54 % (117/217) were female, with a median age of 26 years (interquartile range: 20–40). The majority (88 %; 191/217) presented with pulmonary TB, and most (87 %; 188/217) had favourable treatment outcomes, including treatment completion (52 %; 112/217) and cure (35 %; 76/217). Unfavourable outcomes, including treatment failure (2.3 %; 5/217), loss to follow-up (9.2 %; 20/217), or death (1.8 %; 4/217), were observed in 13 % (29/217) of patients. A total of ten (5 %) patients experienced at least one non-severe adverse drug reaction. Factors associated with unfavourable outcomes included severe thinness (p = 0.019) and male gender (p = 0.012).

Conclusion

Treating INH mono-resistant patients with LfxREZ resulted in satisfactory outcomes and low toxicity. It is important to rule out drug resistance to INH while determining the treatment regimen.
背景肺结核(TB)仍然是全球死亡的一个重要原因,印度占肺结核患者估计人数的 27%。耐多药结核病(MDR-TB)和异烟肼(INH)耐药性给有效治疗带来了更多挑战。我们旨在描述印度孟买计划条件下 INH 单耐药肺结核患者的治疗结果。方法这项回顾性队列研究于 2019-2021 年间在孟买 Shatabdi 医院进行。我们描述了接受利福平、乙胺丁醇、吡嗪酰胺和左氧氟沙星(LfxREZ)治疗 6 个月的 INH 单耐药肺结核患者的临床和人口统计学特征、治疗结果和不利结果的风险因素。结果在 3105 名开始接受治疗的耐药肺结核患者中,217 人(7%)为 INH 单耐药肺结核。其中,54%(117/217)为女性,中位年龄为 26 岁(四分位数间距:20-40)。大多数患者(88%;191/217)表现为肺结核,大多数患者(87%;188/217)的治疗结果良好,包括完成治疗(52%;112/217)和治愈(35%;76/217)。13%的患者(29/217)出现了不利的结果,包括治疗失败(2.3%;5/217)、失去随访(9.2%;20/217)或死亡(1.8%;4/217)。共有 10 名患者(5%)至少出现过一次非严重药物不良反应。与不良反应相关的因素包括严重消瘦(p = 0.019)和男性(p = 0.012)。结论用 LfxREZ 治疗 INH 单耐药患者的疗效令人满意,且毒性较低。在确定治疗方案时,必须排除 INH 的耐药性。
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引用次数: 0
Epidemiology of nontuberculous mycobacteria in the Finger Lakes region of New York 纽约手指湖地区的非结核分枝杆菌流行病学
IF 1.9 Q3 INFECTIOUS DISEASES Pub Date : 2024-10-11 DOI: 10.1016/j.jctube.2024.100483
Clinical-epidemiologic data for all nontuberculous mycobacteria isolated in the 9 County Finger Lakes region of NY from 226 patients between 04/01/2018–03/31/2020 were retrospectively analyzed. Only 51% of patients meeting diagnostic criteria were treated, while 25% not meeting diagnostic criteria were also treated, indicating important knowledge gaps and research opportunities.
我们对纽约州五指湖 9 县地区 226 名患者在 2018 年 4 月 1 日至 2020 年 3 月 31 日期间分离出的所有非结核分枝杆菌的临床流行病学数据进行了回顾性分析。只有 51% 符合诊断标准的患者接受了治疗,而 25% 不符合诊断标准的患者也接受了治疗,这表明存在重要的知识差距和研究机会。
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引用次数: 0
Tuberculosis in South Asia: A regional analysis of burden, progress, and future projections using the global burden of disease (1990–2021) 南亚的结核病:利用全球疾病负担(1990-2021 年)对负担、进展和未来预测进行区域分析
IF 1.9 Q3 INFECTIOUS DISEASES Pub Date : 2024-10-08 DOI: 10.1016/j.jctube.2024.100480

Background

Tuberculosis (TB) is a major public health issue in South Asia and accounts for a large share of the global TB burden. Despite global efforts to curb TB incidence and mortality, progress in South Asia has been uneven, necessitating focused regional analysis to guide effective interventions. This study aims to analyse the trends in the TB burden in South Asia from 1990 to 2021 and project future TB incidence rates up to 2031.

Methods

This study utilized data from the Global Burden of Disease (GBD) 2021 results to analyse trends in age-standardized incidence (ASIR), prevalence (ASPR), mortality (ASMR), and disability-adjusted life years (DALYs) rates (ASDR) associated with TB in South Asia from 1990 to 2021. Joinpoint regression analysis was employed to identify significant trends, whereas ARIMA models were used to project future TB incidence rates up to 2031.

Results

This study revealed significant declines in the ASIR, ASPR, ASDR, and ASMR related to TB in South Asia over the past three decades. Prominent reductions were found in Bangladesh and Bhutan, whereas India, Pakistan, and Nepal continue to bear the highest TB burdens. The ARIMA model projections indicate a continued decline in TB incidence across the region, although the extent of the decline varies by country, with less favourable trends observed in Nepal and Pakistan. The analysis also highlights tobacco use, high fasting plasma glucose, and high body mass index as significant risk factors contributing to the TB burden.

Conclusions

Substantial progress has been made in reducing the TB burden in South Asia; however, sustained and intensified efforts are needed, particularly in countries with inconsistent progress. These findings emphasize the need for targeted interventions to meet the WHO End TB Strategy (WETS) targets by 2035. Continuous monitoring and adaptive strategies will be crucial in maintaining and accelerating progress toward TB elimination in South Asia.
背景结核病(TB)是南亚的一个主要公共卫生问题,在全球结核病负担中占很大比例。尽管全球都在努力遏制结核病的发病率和死亡率,但南亚地区的进展并不均衡,因此有必要进行重点区域分析,以指导采取有效的干预措施。本研究旨在分析 1990 年至 2021 年南亚地区的结核病负担趋势,并预测未来至 2031 年的结核病发病率。本研究利用 2021 年全球疾病负担(GBD)结果中的数据,分析 1990 年至 2021 年南亚地区与结核病相关的年龄标准化发病率(ASIR)、流行率(ASPR)、死亡率(ASMR)和残疾调整生命年(DALYs)率(ASDR)的趋势。这项研究显示,在过去三十年中,南亚与结核病相关的 ASIR、ASPR、ASDR 和 ASMR 显著下降。孟加拉国和不丹的发病率明显下降,而印度、巴基斯坦和尼泊尔的结核病负担仍然最高。ARIMA 模型预测表明,整个地区的肺结核发病率将继续下降,但各国的下降程度不同,尼泊尔和巴基斯坦的趋势较弱。分析还强调,吸烟、空腹血浆葡萄糖过高和体重指数过高是造成结核病负担的重要风险因素。这些发现强调,需要采取有针对性的干预措施,以实现世界卫生组织到 2035 年终结结核病战略 (WETS) 的目标。持续监测和适应性战略对于保持和加快南亚消除结核病的进展至关重要。
{"title":"Tuberculosis in South Asia: A regional analysis of burden, progress, and future projections using the global burden of disease (1990–2021)","authors":"","doi":"10.1016/j.jctube.2024.100480","DOIUrl":"10.1016/j.jctube.2024.100480","url":null,"abstract":"<div><h3>Background</h3><div>Tuberculosis (TB) is a major public health issue in South Asia and accounts for a large share of the global TB burden. Despite global efforts to curb TB incidence and mortality, progress in South Asia has been uneven, necessitating focused regional analysis to guide effective interventions. This study aims to analyse the trends in the TB burden in South Asia from 1990 to 2021 and project future TB incidence rates up to 2031.</div></div><div><h3>Methods</h3><div>This study utilized data from the Global Burden of Disease (GBD) 2021 results to analyse trends in age-standardized incidence (ASIR), prevalence (ASPR), mortality (ASMR), and disability-adjusted life years (DALYs) rates (ASDR) associated with TB in South Asia from 1990 to 2021. Joinpoint regression analysis was employed to identify significant trends, whereas ARIMA models were used to project future TB incidence rates up to 2031.</div></div><div><h3>Results</h3><div>This study revealed significant declines in the ASIR, ASPR, ASDR, and ASMR related to TB in South Asia over the past three decades. Prominent reductions were found in Bangladesh and Bhutan, whereas India, Pakistan, and Nepal continue to bear the highest TB burdens. The ARIMA model projections indicate a continued decline in TB incidence across the region, although the extent of the decline varies by country, with less favourable trends observed in Nepal and Pakistan. The analysis also highlights tobacco use, high fasting plasma glucose, and high body mass index as significant risk factors contributing to the TB burden.</div></div><div><h3>Conclusions</h3><div>Substantial progress has been made in reducing the TB burden in South Asia; however, sustained and intensified efforts are needed, particularly in countries with inconsistent progress. These findings emphasize the need for targeted interventions to meet the WHO End TB Strategy (WETS) targets by 2035. Continuous monitoring and adaptive strategies will be crucial in maintaining and accelerating progress toward TB elimination in South Asia.</div></div>","PeriodicalId":37942,"journal":{"name":"Journal of Clinical Tuberculosis and Other Mycobacterial Diseases","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2024-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142528132","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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Journal of Clinical Tuberculosis and Other Mycobacterial Diseases
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