高强度间歇训练与中等强度连续训练对心力衰竭患者生活质量的比较影响:随机对照试验的研究方案

Clinical trials and regulatory science in cardiology Pub Date : 2016-01-01 DOI:10.1016/j.ctrsc.2015.11.005

Anderson Zampier Ulbrich , Vitor Giatte Angarten , Almir Schmitt Netto , Sabrina Weiss Sties , Daiana Cristine Bündchen , Lourenço Sampaio de Mara , Véronique A. Cornelissen , Tales de Carvalho

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引用次数: 44

摘要

目的比较高强度间歇训练(HIIT)与中等强度连续训练(MICT)对慢性心力衰竭(CHF)患者体能和生活质量(QoL)的影响。方法22例男性CHF患者(LVEF <45%，平均年龄53.8±8岁)，在12周的有氧训练前后进行，每次60分钟，每周三次。患者按1:1的比例随机分为MICT组(n = 10)和HIIT组(n = 12)。这两个训练项目都包括跑步机锻炼。MICT组为峰值心率(HR)的75%，HIIT组为峰值心率的约95%。结果测量包括生活质量评估(明尼苏达州心力衰竭患者问卷(MLHFQ)和SF-36)， 6分钟步行测试(6MWT)和峰值耗氧量(VO2峰值)的测量。结果运动与MCIT和HIIT相比，6MWT分别显著增加19.4%和23.1% (p <0.001)，但组间差异不存在。观察到，HIIT组和MCIT组的VO2峰值分别提高了11.2%和8.3%，组间差异(p <0.01)。两组患者的生活质量均有显著改善(p值时间效应)。所有患者在所有领域均较基线有显著改善，两组均观察到(p <0.05)，功能容量组间差异(SF-36)。两组疼痛(SF-36)均无变化。结论两种训练方案在改善慢性心力衰竭患者的生活质量和功能能力方面效果相同。试验注册(http://www.ensaiosclinicos.gov.br/): RBR-6hk9p6;于2013年5月15日注册。

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Comparative effects of high intensity interval training versus moderate intensity continuous training on quality of life in patients with heart failure: Study protocol for a randomized controlled trial

Purpose

To compare the effect of high intensity interval training (HIIT) and moderate intensity continuous training (MICT) on physical fitness and quality of life (QoL) in patients with chronic heart failure (CHF).

Methods

Twenty-two male CHF patients (LVEF < 45%, mean age 53.8 ± 8 yr) were studied before and after 12 weeks of supervised aerobic training for 60 min, three times a week. Patients were randomly (1:1) to MICT (n = 10) and HIIT (n = 12). Both training programs involved treadmill exercise. The group MICT at 75% of peak heart rate (HR) and HIIT at ≈ 95% of peak HR. Outcome measurements included an assessment of QoL (Minnesota Living with Heart Failure Questionnaire (MLHFQ) and SF-36), measurements of 6-min walk test (6MWT) and peak oxygen consumption (VO₂ peak).

Results

Exercise was associated with a significant increased of 6MWT in 19.4% and 23.1% from MCIT and HIIT, respectively (p < 0.001), but not between-group differences. It was observed an improvement in VO₂ peak by 11.2% in the HIIT group and 8.3% in the MCIT group, with between-group differences (p < 0.01). Quality of life improved significantly and in all domains in both groups (p-value time-effect). All patients showed significant improvements in all domains from baseline, it was observed in both groups (p < 0.05), with between-group differences for functional capacity (SF-36). No changes were observed in pain (SF-36) for both groups.