Efectos del mantenimiento de varias anestesias sobre los niveles séricos de selenio, cobre, cinc y hierro y la capacidad antioxidante

Background and objectives

In this study, we aimed to investigate the effects of sevoflurane, desflurane and propofol maintenances on serum levels of selenium, copper, zinc, iron, malondialdehyde, and glutathion peroxidase measurements, and antioxidant capacity.

Methods

60 patients scheduled for unilateral lower extremity surgery which would be performed with tourniquet under general anesthesia were divided into three groups. Blood samples were collected to determine the baseline serum levels of selenium, copper, zinc, iron, malondialdehyde and glutathion peroxidase. Anesthesia was induced using 2-2.5 mg/kg⁻¹ propofol, 1 mg/kg⁻¹ lidocaine and 0.6 mg/kg⁻¹ rocuronium. In the maintenance of anesthesia, under carrier gas of 50:50% O₂:N₂O 4 L/min⁻¹, 1 MAC sevoflorane was administered to group S and 1 MAC desflurane to group D; and under carrier gas of 50:50% O₂:air 4 L/min⁻¹ 6 mg/kg/h⁻¹ propofol and 1 μg/kg/h⁻¹ fentanyl infusion were administered to group P. At postoperative blood specimens were collected again.

Results

It was observed that only in group S and P, levels of malondialdehyde decreased at postoperative 48th hour; levels of glutathion peroxidase increased in comparison to the baseline values. Selenium levels decreased in group S and group P, zinc levels decreased in group P, and iron levels decreased in all three groups, and copper levels did not change in any groups in the postoperative period.

Conclusion

According to the markers of malondialdehyde and glutathion peroxidase, it was concluded that maintenance of general anesthesia using propofol and sevoflurane activated the antioxidant system against oxidative stress and using desflurane had no effects on oxidative stress and antioxidant system.