多发性硬化症和昼夜节律:饮食可以作为治疗方法吗?

IF 5.6 2区 医学 Q1 PHYSIOLOGY Acta Physiologica Pub Date : 2023-01-26 DOI:10.1111/apha.13939
Olga Pivovarova-Ramich, Hanna Gwendolyn Zimmermann, Friedemann Paul
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引用次数: 5

摘要

多发性硬化症(MS)是一种发病率和患病率不断上升的中枢神经系统(CNS)自身免疫性炎症性和神经退行性疾病。MS与炎症和代谢紊乱有关,正如人类和动物的初步数据表明,这些紊乱可能是由昼夜节律紊乱介导的。营养习惯可影响MS的发病风险,饮食干预可有效调节MS病程。时间治疗方法,如限时饮食(TRE),可能通过稳定生物钟和恢复免疫和代谢节律,从而潜在地抵消疾病进展,从而使MS患者受益。本文综述了有关饮食干预多发性硬化症、昼夜节律及其在多发性硬化症中的破坏的研究,包括时钟基因变异、昼夜节律激素和视网膜-下丘脑束的变化。此外,我们提出的研究报告了MS的日变化,这可能是由于昼夜节律紊乱造成的。最后,我们建议像TRE这样的时间营养方法如何抵消多发性硬化症的活动。
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Multiple sclerosis and circadian rhythms: Can diet act as a treatment?

Multiple sclerosis (MS) is an autoimmune inflammatory and neurodegenerative disease of the central nervous system (CNS) with increasing incidence and prevalence. MS is associated with inflammatory and metabolic disturbances that, as preliminary human and animal data suggest, might be mediated by disruption of circadian rhythmicity. Nutrition habits can influence the risk for MS, and dietary interventions may be effective in modulating MS disease course. Chronotherapeutic approaches such as time-restricted eating (TRE) may benefit people with MS by stabilizing the circadian clock and restoring immunological and metabolic rhythms, thus potentially counteracting disease progression. This review provides a summary of selected studies on dietary intervention in MS, circadian rhythms, and their disruption in MS, including clock gene variations, circadian hormones, and retino-hypothalamic tract changes. Furthermore, we present studies that reported diurnal variations in MS, which might result from circadian disruption. And lastly, we suggest how chrononutritive approaches like TRE might counteract MS disease activity.

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来源期刊
Acta Physiologica
Acta Physiologica 医学-生理学
CiteScore
11.80
自引率
15.90%
发文量
182
审稿时长
4-8 weeks
期刊介绍: Acta Physiologica is an important forum for the publication of high quality original research in physiology and related areas by authors from all over the world. Acta Physiologica is a leading journal in human/translational physiology while promoting all aspects of the science of physiology. The journal publishes full length original articles on important new observations as well as reviews and commentaries.
期刊最新文献
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