Shidong Wang, Chenglong Chen, Juan Wang, Chen-Bo-Wen Li, Jinling Zhou, Yi-Xuan Liu, Yu-Qi Jiang, Lifeng Zhu, Chao Li, Wen Gong, Wei Guo, Xiaodong Tang, Fang-Zhou Yao, Ke Wang
{"title":"利用缺陷驱动的无铅压电材料实现骨肉瘤的协同化学-压电治疗","authors":"Shidong Wang, Chenglong Chen, Juan Wang, Chen-Bo-Wen Li, Jinling Zhou, Yi-Xuan Liu, Yu-Qi Jiang, Lifeng Zhu, Chao Li, Wen Gong, Wei Guo, Xiaodong Tang, Fang-Zhou Yao, Ke Wang","doi":"10.1002/adfm.202208128","DOIUrl":null,"url":null,"abstract":"<p>Osteosarcoma (OS) is a lethal malignancy of the bone, jeopardizing the life of an enormous population worldwide. There are grand ongoing challenges to improve overall patient survival. Herein, a synergetic chemo-piezodynamic therapy by defect-engineered lead-free piezoelectric (K,Na)NbO<sub>3</sub> (KNN) is reported, which can generate reactive oxygen species (ROS) to effectively circumvent OS. Significant anti-tumor effects in human OS cells, and xenograft OS models are observed that almost stop the growth of the tumors after treatment with KNN because of oxygen vacancies-driven free radical catalysis (namely, the chemodynamic therapy), and those effects are enhanced after introducing ultrasonic vibration enabled by the ultrasound-triggered piezocatalysis (piezodynamic therapy). Moreover, it is found that KNN induces apoptosis and autophagy of OS cells and shows good histocompatibility on evaluation in mouse models, which has no killing effect on normal cells and no toxic effects on organs in vivo. Both in vitro cellular level evaluation and in vivo OS xenograft assessment have demonstrated that injectable KNN nanocrystals induce cytotoxicity and tumor eradication by the synergy of chemo-piezocatalytic effects. This study opens an avenue for customized design of high-tech nanocatalysts by integrating synergetic catalytic effects for therapeutic applications in tumor healthcare.</p>","PeriodicalId":112,"journal":{"name":"Advanced Functional Materials","volume":null,"pages":null},"PeriodicalIF":18.5000,"publicationDate":"2022-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"11","resultStr":"{\"title\":\"Synergetic Chemo-Piezodynamic Therapy of Osteosarcoma Enabled by Defect-Driven Lead-Free Piezoelectrics\",\"authors\":\"Shidong Wang, Chenglong Chen, Juan Wang, Chen-Bo-Wen Li, Jinling Zhou, Yi-Xuan Liu, Yu-Qi Jiang, Lifeng Zhu, Chao Li, Wen Gong, Wei Guo, Xiaodong Tang, Fang-Zhou Yao, Ke Wang\",\"doi\":\"10.1002/adfm.202208128\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p>Osteosarcoma (OS) is a lethal malignancy of the bone, jeopardizing the life of an enormous population worldwide. There are grand ongoing challenges to improve overall patient survival. Herein, a synergetic chemo-piezodynamic therapy by defect-engineered lead-free piezoelectric (K,Na)NbO<sub>3</sub> (KNN) is reported, which can generate reactive oxygen species (ROS) to effectively circumvent OS. Significant anti-tumor effects in human OS cells, and xenograft OS models are observed that almost stop the growth of the tumors after treatment with KNN because of oxygen vacancies-driven free radical catalysis (namely, the chemodynamic therapy), and those effects are enhanced after introducing ultrasonic vibration enabled by the ultrasound-triggered piezocatalysis (piezodynamic therapy). Moreover, it is found that KNN induces apoptosis and autophagy of OS cells and shows good histocompatibility on evaluation in mouse models, which has no killing effect on normal cells and no toxic effects on organs in vivo. Both in vitro cellular level evaluation and in vivo OS xenograft assessment have demonstrated that injectable KNN nanocrystals induce cytotoxicity and tumor eradication by the synergy of chemo-piezocatalytic effects. This study opens an avenue for customized design of high-tech nanocatalysts by integrating synergetic catalytic effects for therapeutic applications in tumor healthcare.</p>\",\"PeriodicalId\":112,\"journal\":{\"name\":\"Advanced Functional Materials\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":18.5000,\"publicationDate\":\"2022-08-26\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"11\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Advanced Functional Materials\",\"FirstCategoryId\":\"88\",\"ListUrlMain\":\"https://onlinelibrary.wiley.com/doi/10.1002/adfm.202208128\",\"RegionNum\":1,\"RegionCategory\":\"材料科学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"CHEMISTRY, MULTIDISCIPLINARY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Advanced Functional Materials","FirstCategoryId":"88","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1002/adfm.202208128","RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CHEMISTRY, MULTIDISCIPLINARY","Score":null,"Total":0}
Synergetic Chemo-Piezodynamic Therapy of Osteosarcoma Enabled by Defect-Driven Lead-Free Piezoelectrics
Osteosarcoma (OS) is a lethal malignancy of the bone, jeopardizing the life of an enormous population worldwide. There are grand ongoing challenges to improve overall patient survival. Herein, a synergetic chemo-piezodynamic therapy by defect-engineered lead-free piezoelectric (K,Na)NbO3 (KNN) is reported, which can generate reactive oxygen species (ROS) to effectively circumvent OS. Significant anti-tumor effects in human OS cells, and xenograft OS models are observed that almost stop the growth of the tumors after treatment with KNN because of oxygen vacancies-driven free radical catalysis (namely, the chemodynamic therapy), and those effects are enhanced after introducing ultrasonic vibration enabled by the ultrasound-triggered piezocatalysis (piezodynamic therapy). Moreover, it is found that KNN induces apoptosis and autophagy of OS cells and shows good histocompatibility on evaluation in mouse models, which has no killing effect on normal cells and no toxic effects on organs in vivo. Both in vitro cellular level evaluation and in vivo OS xenograft assessment have demonstrated that injectable KNN nanocrystals induce cytotoxicity and tumor eradication by the synergy of chemo-piezocatalytic effects. This study opens an avenue for customized design of high-tech nanocatalysts by integrating synergetic catalytic effects for therapeutic applications in tumor healthcare.
期刊介绍:
Firmly established as a top-tier materials science journal, Advanced Functional Materials reports breakthrough research in all aspects of materials science, including nanotechnology, chemistry, physics, and biology every week.
Advanced Functional Materials is known for its rapid and fair peer review, quality content, and high impact, making it the first choice of the international materials science community.