Susann Weihrauch-Blüher, Susanna Wiegand, Paul Weihe, Nicole Prinz, Daniel Weghuber, Georg Leipold, Almut Dannemann, Lara Bergjohann, Thomas Reinehr, Reinhard W. Holl, for the APV study group
{"title":"儿童和青少年肥胖患者的尿酸和γ -谷氨酰转移酶:与人体测量指标和心脏代谢风险标志物的关联，这取决于青春期、性别、体重减轻程度和患者护理类型:对肥胖患者随访登记的评估","authors":"Susann Weihrauch-Blüher, Susanna Wiegand, Paul Weihe, Nicole Prinz, Daniel Weghuber, Georg Leipold, Almut Dannemann, Lara Bergjohann, Thomas Reinehr, Reinhard W. Holl, for the APV study group","doi":"10.1111/ijpo.12989","DOIUrl":null,"url":null,"abstract":"<div>\n \n \n <section>\n \n <h3> Objectives</h3>\n \n <p>Associations between body mass index (BMI)- standard deviation score (SDS)/waist-to-height ratio (WHtR) were studied with (i) serum uric acid (sUA)/gamma-glutamyl-transferase (GGT) and (ii) cardiometabolic risk markers in children with obesity, considering sex, pubertal development, and degree of weight loss/type of patient care.</p>\n </section>\n \n <section>\n \n <h3> Methods</h3>\n \n <p>102 936 children from the Adiposity-Follow-up registry (APV; 47% boys) were included. Associations were analysed between sUA/GGT and anthropometrics, transaminases, lipids, fasting insulin (FI), homeostasis model assessment of insulin resistance (HOMA-IR), triglycerides to HDL-cholesterol (TG/HDL)-ratio.</p>\n \n <p>Follow-up analyses (3–24 months after baseline) considered a BMI-SDS reduction ≥0.2 (<i>n</i> = 11 096) or ≥0.5 (<i>n</i> = 3728). Partialized correlation analyses for sex and BMI-SDS were performed, taking pubertal development into consideration.</p>\n </section>\n \n <section>\n \n <h3> Results</h3>\n \n <p>At baseline, BMI-SDS showed the strongest correlations to sUA (<i>r</i> = 0.35; <i>n</i> = 26 529), HOMA-IR/FI (<i>r</i> = 0.30; <i>n</i> = 5513 /<i>n</i> = 5880), TG/HDL-ratio (<i>r</i> = 0.23; <i>n</i> = 24 501), and WHtR to sUA (<i>r</i> = 0.32; <i>n</i> = 10 805), GGT (<i>r</i> = 0.34; <i>n</i> = 11 862) and Alanine-aminotransferase (ALAT) (<i>r</i> = 0.33; <i>n</i> = 11 821), with stronger correlations in boys (WHtR and GGT: <i>r</i> = 0.36, <i>n</i> = 5793) and prepubertal children (<i>r</i> = 0.36; <i>n</i> = 2216). GGT and sUA (after partializing effects of age, sex, BMI-SDS) showed a correlation to TG/HDL-ratio (<i>r</i> = 0.27; <i>n</i> = 24 501).</p>\n \n <p>Following a BMI-SDS reduction ≥0.2 or ≥0.5, GGT was most strongly related to Aspartate-aminotransferase (ASAT)/ ALAT, most evident in prepuberty and with increasing weight loss, and also to TG/HDL-ratio (<i>r</i> = 0.22; <i>n</i> = 1528). Prepubertal children showed strongest correlations between BMI-SDS/WHtR and GGT. ΔBMI-SDS was strongly correlated to ΔsUA (<i>r</i> = 0.30; <i>n</i> = 4160) and ΔGGT (<i>r</i> = 0.28; <i>n</i> = 3562), and ΔWHtR to ΔGGT (<i>r</i> = 0.28; <i>n</i> = 3562) (all p < 0.0001).</p>\n </section>\n \n <section>\n \n <h3> Conclusion</h3>\n \n <p>Abdominal obesity may trigger hyperuricemia and hepatic involvement already in prepuberty. This may be stronger in infancy than anticipated to date. Even moderate weight loss has favourable effects on cardiometabolic risk profile and glucose homeostasis.</p>\n </section>\n </div>","PeriodicalId":217,"journal":{"name":"Pediatric Obesity","volume":"18 3","pages":""},"PeriodicalIF":2.7000,"publicationDate":"2022-11-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/ijpo.12989","citationCount":"3","resultStr":"{\"title\":\"Uric acid and gamma-glutamyl-transferase in children and adolescents with obesity: Association to anthropometric measures and cardiometabolic risk markers depending on pubertal stage, sex, degree of weight loss and type of patient care: Evaluation of the adiposity patient follow-up registry\",\"authors\":\"Susann Weihrauch-Blüher, Susanna Wiegand, Paul Weihe, Nicole Prinz, Daniel Weghuber, Georg Leipold, Almut Dannemann, Lara Bergjohann, Thomas Reinehr, Reinhard W. Holl, for the APV study group\",\"doi\":\"10.1111/ijpo.12989\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div>\\n \\n \\n <section>\\n \\n <h3> Objectives</h3>\\n \\n <p>Associations between body mass index (BMI)- standard deviation score (SDS)/waist-to-height ratio (WHtR) were studied with (i) serum uric acid (sUA)/gamma-glutamyl-transferase (GGT) and (ii) cardiometabolic risk markers in children with obesity, considering sex, pubertal development, and degree of weight loss/type of patient care.</p>\\n </section>\\n \\n <section>\\n \\n <h3> Methods</h3>\\n \\n <p>102 936 children from the Adiposity-Follow-up registry (APV; 47% boys) were included. Associations were analysed between sUA/GGT and anthropometrics, transaminases, lipids, fasting insulin (FI), homeostasis model assessment of insulin resistance (HOMA-IR), triglycerides to HDL-cholesterol (TG/HDL)-ratio.</p>\\n \\n <p>Follow-up analyses (3–24 months after baseline) considered a BMI-SDS reduction ≥0.2 (<i>n</i> = 11 096) or ≥0.5 (<i>n</i> = 3728). Partialized correlation analyses for sex and BMI-SDS were performed, taking pubertal development into consideration.</p>\\n </section>\\n \\n <section>\\n \\n <h3> Results</h3>\\n \\n <p>At baseline, BMI-SDS showed the strongest correlations to sUA (<i>r</i> = 0.35; <i>n</i> = 26 529), HOMA-IR/FI (<i>r</i> = 0.30; <i>n</i> = 5513 /<i>n</i> = 5880), TG/HDL-ratio (<i>r</i> = 0.23; <i>n</i> = 24 501), and WHtR to sUA (<i>r</i> = 0.32; <i>n</i> = 10 805), GGT (<i>r</i> = 0.34; <i>n</i> = 11 862) and Alanine-aminotransferase (ALAT) (<i>r</i> = 0.33; <i>n</i> = 11 821), with stronger correlations in boys (WHtR and GGT: <i>r</i> = 0.36, <i>n</i> = 5793) and prepubertal children (<i>r</i> = 0.36; <i>n</i> = 2216). GGT and sUA (after partializing effects of age, sex, BMI-SDS) showed a correlation to TG/HDL-ratio (<i>r</i> = 0.27; <i>n</i> = 24 501).</p>\\n \\n <p>Following a BMI-SDS reduction ≥0.2 or ≥0.5, GGT was most strongly related to Aspartate-aminotransferase (ASAT)/ ALAT, most evident in prepuberty and with increasing weight loss, and also to TG/HDL-ratio (<i>r</i> = 0.22; <i>n</i> = 1528). Prepubertal children showed strongest correlations between BMI-SDS/WHtR and GGT. ΔBMI-SDS was strongly correlated to ΔsUA (<i>r</i> = 0.30; <i>n</i> = 4160) and ΔGGT (<i>r</i> = 0.28; <i>n</i> = 3562), and ΔWHtR to ΔGGT (<i>r</i> = 0.28; <i>n</i> = 3562) (all p < 0.0001).</p>\\n </section>\\n \\n <section>\\n \\n <h3> Conclusion</h3>\\n \\n <p>Abdominal obesity may trigger hyperuricemia and hepatic involvement already in prepuberty. This may be stronger in infancy than anticipated to date. Even moderate weight loss has favourable effects on cardiometabolic risk profile and glucose homeostasis.</p>\\n </section>\\n </div>\",\"PeriodicalId\":217,\"journal\":{\"name\":\"Pediatric Obesity\",\"volume\":\"18 3\",\"pages\":\"\"},\"PeriodicalIF\":2.7000,\"publicationDate\":\"2022-11-06\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://onlinelibrary.wiley.com/doi/epdf/10.1111/ijpo.12989\",\"citationCount\":\"3\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Pediatric Obesity\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://onlinelibrary.wiley.com/doi/10.1111/ijpo.12989\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"PEDIATRICS\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Pediatric Obesity","FirstCategoryId":"3","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1111/ijpo.12989","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"PEDIATRICS","Score":null,"Total":0}
Uric acid and gamma-glutamyl-transferase in children and adolescents with obesity: Association to anthropometric measures and cardiometabolic risk markers depending on pubertal stage, sex, degree of weight loss and type of patient care: Evaluation of the adiposity patient follow-up registry
Objectives
Associations between body mass index (BMI)- standard deviation score (SDS)/waist-to-height ratio (WHtR) were studied with (i) serum uric acid (sUA)/gamma-glutamyl-transferase (GGT) and (ii) cardiometabolic risk markers in children with obesity, considering sex, pubertal development, and degree of weight loss/type of patient care.
Methods
102 936 children from the Adiposity-Follow-up registry (APV; 47% boys) were included. Associations were analysed between sUA/GGT and anthropometrics, transaminases, lipids, fasting insulin (FI), homeostasis model assessment of insulin resistance (HOMA-IR), triglycerides to HDL-cholesterol (TG/HDL)-ratio.
Follow-up analyses (3–24 months after baseline) considered a BMI-SDS reduction ≥0.2 (n = 11 096) or ≥0.5 (n = 3728). Partialized correlation analyses for sex and BMI-SDS were performed, taking pubertal development into consideration.
Results
At baseline, BMI-SDS showed the strongest correlations to sUA (r = 0.35; n = 26 529), HOMA-IR/FI (r = 0.30; n = 5513 /n = 5880), TG/HDL-ratio (r = 0.23; n = 24 501), and WHtR to sUA (r = 0.32; n = 10 805), GGT (r = 0.34; n = 11 862) and Alanine-aminotransferase (ALAT) (r = 0.33; n = 11 821), with stronger correlations in boys (WHtR and GGT: r = 0.36, n = 5793) and prepubertal children (r = 0.36; n = 2216). GGT and sUA (after partializing effects of age, sex, BMI-SDS) showed a correlation to TG/HDL-ratio (r = 0.27; n = 24 501).
Following a BMI-SDS reduction ≥0.2 or ≥0.5, GGT was most strongly related to Aspartate-aminotransferase (ASAT)/ ALAT, most evident in prepuberty and with increasing weight loss, and also to TG/HDL-ratio (r = 0.22; n = 1528). Prepubertal children showed strongest correlations between BMI-SDS/WHtR and GGT. ΔBMI-SDS was strongly correlated to ΔsUA (r = 0.30; n = 4160) and ΔGGT (r = 0.28; n = 3562), and ΔWHtR to ΔGGT (r = 0.28; n = 3562) (all p < 0.0001).
Conclusion
Abdominal obesity may trigger hyperuricemia and hepatic involvement already in prepuberty. This may be stronger in infancy than anticipated to date. Even moderate weight loss has favourable effects on cardiometabolic risk profile and glucose homeostasis.
期刊介绍：
Pediatric Obesity is a peer-reviewed, monthly journal devoted to research into obesity during childhood and adolescence. The topic is currently at the centre of intense interest in the scientific community, and is of increasing concern to health policy-makers and the public at large.
Pediatric Obesity has established itself as the leading journal for high quality papers in this field, including, but not limited to, the following:
Genetic, molecular, biochemical and physiological aspects of obesity – basic, applied and clinical studies relating to mechanisms of the development of obesity throughout the life course and the consequent effects of obesity on health outcomes
Metabolic consequences of child and adolescent obesity
Epidemiological and population-based studies of child and adolescent overweight and obesity
Measurement and diagnostic issues in assessing child and adolescent adiposity, physical activity and nutrition
Clinical management of children and adolescents with obesity including studies of treatment and prevention
Co-morbidities linked to child and adolescent obesity – mechanisms, assessment, and treatment
Life-cycle factors eg familial, intrauterine and developmental aspects of child and adolescent obesity
Nutrition security and the "double burden" of obesity and malnutrition
Health promotion strategies around the issues of obesity, nutrition and physical activity in children and adolescents
Community and public health measures to prevent overweight and obesity in children and adolescents.
京公网安备 11010802042870号
京ICP备2023020795号-1
分享
求助内容：
应助结果提醒方式：
扫码关注我们
